-
作者：Wright, Colin M.; Holbrook, C. Tate
-
作者：Itoh, Hironori; Yamashita, Hiroto; Wada, Kaede C.; Yonemaru, Jun- ichi
作者单位：National Agriculture & Food Research Organization - Japan; National Agriculture & Food Research Organization - Japan; Shizuoka University
摘要：Decreased production of crops due to climate change has been predicted scientifically. While climate - resilient crops are necessary to ensure food security and support sustainable agriculture, predicting crop growth under future global warming is challenging. Therefore, we aimed to assess the impact of realistic global warming conditions on rice cultivation. We developed a crop evaluation platform, the agro - environment (AE) emulator, which generates diverse environments by implementing the ...
-
作者：King, Harry R.; Bycroft, Mark; Nguyen, Thanh-Binh; Kelly, Geoff; Vinogradov, Alexander A.; Rowling, Pamela J. E.; Stott, Katherine; Ascher, David B.; Suga, Hiroaki; Itzhaki, Laura S.; Artavanis -Tsakonas, Katerina
作者单位：University of Cambridge; University of Cambridge; University of Queensland; Francis Crick Institute; University of Tokyo; University of Cambridge
摘要：The ubiquitin-proteasome system is essential to all eukaryotes and has been shown to be critical to parasite survival as well, including Plasmodium falciparum, the causative agent of the deadliest form of malarial disease. Despite the central role of the ubiquitin-proteasome pathway to parasite viability across its entire life- cycle, specific inhibitors targeting the individual enzymes mediating ubiquitin attachment and removal do not currently exist. The ability to disrupt P. falciparum grow...
-
作者：Blanco, Alexandra; Coronado, Robert A.; Arun, Neha; Ma, Kelly; Dar, Roy D.; Kieffer, Collin
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：HIV latency regulation in monocytes and macrophages can vary according to signals directing differentiation, polarization, and function. To investigate these processes, we generated an HIV latency model in THP- 1 monocytes and showed differential levels of HIV reactivation among clonal populations. Monocyte- to- macrophage differentiation of HIV- infected primary human CD14+ and THP- 1 cells induced HIV reactivation and showed that virus production increased concomitant with macrophage differe...
-
作者：Bellone, Stefania; Jeong, Kyungjo; Halle, Mari Kylleso; Krakstad, Camilla; Mcnamara, Blair; Greenman, Michelle; Mutlu, Levent; Demirkiran, Cem; Hartwich, Tobias Max Philipp; Yang-Hartwich, Yang; Zipponi, Margherita; Buza, Natalia; Hui, Pei; Raspagliesi, Francesco; Lopez, Salvatore; Paolini, Biagio; Milione, Massimo; Perrone, Emanuele; Scambia, Giovanni; Altwerger, Gary; Ravaggi, Antonella; Bignotti, Eliana; Huang, Gloria S.; Andikyan, Vaagn; Clark, Mitchell; Ratner, Elena; Azodi, Masoud; Schwartz, Peter E.; Quick, Charles M.; Angioli, Roberto; Terranova, Corrado; Zaidi, Samir; Nandi, Shuvro; Alexandrov, Ludmil B.; Siegel, Eric R.; Choi, Jungmin; Schlessinger, Joseph; Santin, Alessandro D.
作者单位：Yale University; Korea University; Korea University Medicine (KU Medicine); University of Bergen; University of Bergen; Haukeland University Hospital; Yale University; Fondazione IRCCS Istituto Nazionale Tumori Milan; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Hospital Spedali Civili Brescia; University of Brescia; University of Arkansas System; University of Arkansas Medical Sciences; University Campus Bio-Medico - Rome Italy; Memorial Sloan Kettering Cancer Center; University of California System; University of California San Diego; University of Arkansas System; University of Arkansas Medical Sciences; Yale University; IRCCS Istituto Tumori Bari Giovanni Paolo II
摘要：High- grade neuroendocrine cervical cancers (NETc) are exceedingly rare, highly aggressive tumors. We analyzed 64 NETc tumor samples by whole- exome sequencing (WES). Human papillomavirus DNA was detected in 65.6% (42/64) of the tumors. Recurrent WDFY3, a gene not yet implicated in NETc. Somatic CNV analysis identified two copy number gains (3q27.1 and 19q13.12) and five copy number losses (1p36.21/5q31.3/6p 22.2/9q21.11/11p15.5). Also, gene fusions affecting the ACLY- CRHR1 and PVT1- MYC gene...
-
作者：Fidino, Mason; Sander, Heather A.; Lewis, Jesse S.; Lehrer, Elizabeth W.; Rivera, Kimberly; Murray, Maureen H.; Adams, Henry C.; Kase, Anna; Flores, Andrea; Stankowich, Theodore; Schell, Christopher J.; Salsbury, Carmen M.; Rohnke, Adam T.; Jordan, Mark J.; Green, Austin M.; Gramza, Ashley R.; Zellmer, Amanda J.; Williamson, Jacque; Surasinghe, Thilina D.; Storm, Hunter; Sparks, Kimberly L.; Ryan, Travis J.; Remine, Katie R.; Pendergast, Mary E.; Mullen, Kayleigh; Minier, Darren E.; Middaugh, Christopher R.; Mertl, Amy L.; Mcclung, Maureen R.; Long, Robert A.; Larson, Rachel N.; Kohl, Michel T.; Harris, Lavendar R.; Hall, Courtney T.; Haight, Jeffrey D.; Drake, David; Davidge, Alyssa M.; Cheek, Ann O.; Bloch, Christopher P.; Biro, Elizabeth G.; Anthonysamy, Whitney J. B.; Angstmann, Julia L.; Allen, Maximilian L.; Adalsteinsson, Solny A.; Gianotti, Anne G. Short; Lamontagne, Jalene M.; Candusso, Tiziana A. Gelmi; Magle, Seth B.
作者单位：University of Iowa; Arizona State University; California State University System; California State University Long Beach; University of California System; University of California Berkeley; Butler University; Mississippi State University; Seattle University; Utah System of Higher Education; University of Utah; Occidental College; Massachusetts System of Public Higher Education; Bridgewater State University; Portland State University; Lesley University; University System of Georgia; University of Georgia; Arizona State University; Arizona State University-Tempe; University of Wisconsin System; University of Wisconsin Madison; University of Colorado System; University of Colorado Denver; University of Houston System; University of Houston; Washington University (WUSTL); University of Health Sciences & Pharmacy in St. Louis; Butler University; University of Illinois System; University of Illinois Urbana-Champaign; Illinois Natural History Survey; Boston University; DePaul University; University of Toronto
摘要：While there is increasing recognition that social processes in cities like gentrification have ecological consequences, we lack nuanced understanding of the ways gentrification affects urban biodiversity. We analyzed a large camera trap dataset of mammals (>500 g) to evaluate how gentrification impacts species richness and community composition across 23 US cities. After controlling for the negative effect of impervious cover, gentrified parts of cities had the highest mammal species richness....
-
作者：Bach, Eviatar; Krishnamurthy, V.; Mote, Safa; Shukla, Jagadish; Sharma, A. Surjalal; Kalnay, Eugenia; Ghil, Michael
作者单位：California Institute of Technology; California Institute of Technology; Center for Ocean Land Atmosphere Studies; George Mason University; Portland State University; University System of Maryland; University of Maryland College Park; George Mason University; University System of Maryland; University of Maryland College Park; Universite PSL; Ecole Normale Superieure (ENS); Universite PSL; Ecole Normale Superieure (ENS); Institut Polytechnique de Paris; Ecole Polytechnique; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); Universite PSL; Ecole Normale Superieure (ENS); Universite Paris Saclay; Universite PSL; University of California System; University of California Los Angeles; Imperial College London
摘要：Predicting the temporal , spatial patterns of South Asian monsoon rainfall within a season is of critical importance due to its impact on agriculture, water availability , flooding. The monsoon intraseasonal oscillation (MISO) is a robust northward - propagating mode that determines the active and break phases of the monsoon and much of the regional distribution of rainfall. However, dynamical atmospheric forecast models predict this mode poorly. Data -driven methods for MISO prediction have s...
-
作者：Deng, Hu; Liu, Lingyu; Tang, Xiaping; Lu, Yingxian; Wang, Xiaofei; Zhao, Yanyu; Shi, Yigong
作者单位：Tsinghua University; Tsinghua University; Peking University; Westlake Laboratory; Westlake University; Westlake University; Westlake University
摘要：Electromagnetic radiation (EMR) in the environment, particularly in the microwave range, may constitute a public health concern. Exposure to 2.4 GHz EMR modulated by 100 Hz square pulses was recently reported to markedly increase wakefulness in mice. Here, we demonstrate that a similar wakefulness increase can be induced by the modulation frequency of 1,000 Hz, but not 10 Hz. In contrast to the carrier frequency of 2.4 GHz, 935 MHz EMR of the same power density has little impact on wakefulness...
-
作者：Wen, Xiaohong; Huang, Zhixiang; Yang, Xiaohai; He, Xiaoxiao; Li, Lie; Chen, Haiyan; Wang, Kemin; Guo, Qiuping; Liu, Jianbo
作者单位：Hunan University; Hunan University; Hunan University; Hunan University
摘要：Multidrug resistance (MDR) is a major factor in the failure of many forms of tumor chemotherapy. Development of a specific ligand for MDR- reversal would enhance the intracellular accumulation of therapeutic agents and effectively improve the tumor treatments. Here, an aptamer was screened against a doxorubicin (DOX)- resistant human hepatocellular carcinoma cell line (HepG2/DOX) via cell - based systematic evolution of ligands by exponential enrichment. A 50 nt truncated sequence termed d3 wa...
-
作者：Keum, Byeong-Rak; Kim, Hong Jin; Lee, Juhun; Lee, Minji; Hong, Sin-Hyoung; Chang, Ha Kyun; Han, Jin-Kwan; Kim, Sanguk; Chang, Dong-Gune; Kim, Gun-Hwa
