Proceedings of the National Academy of Sciences of the United States of America

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• Profile of Susan Goldin-Meadow AI翻译
  作者：Ravindran, Sandeep
• Adaptive expression of phage auxiliary metabolic genes in paddy soils and their contribution toward global carbon sequestration AI翻译
  作者：Zhu, Dong; Liu, Shu-Yue; Sun, Ming-Ming; Yi, Xing-Yun; Duan, Gui-Lan; Ye, Mao; Gillings, Michael R.; Zhu, Yong-Guan
  作者单位：Chinese Academy of Sciences; Institute of Urban Environment, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Nanjing Agricultural University; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Macquarie University
  摘要：Habitats with intermittent flooding, such as paddy soils, are crucial reservoirs in the global carbon pool; however, the effect of phage-host interactions on the biogeochemical cycling of carbon in paddy soils remains unclear. Hence, this study applied multiomics and global datasets integrated with validation experiments to investigate phage-host community interactions and the potential of phages to impact carbon sequestration in paddy soils. The results demonstrated that paddy soil phages har...
• New Estimates of US Civil War mortality from full-census records AI翻译
  作者：Barcelo, Joan; Jensen, Jeffrey L.; Peisakhin, Leonid; Zhai, Haoyu
  作者单位：New York University; New York University Abu Dhabi
  摘要：The Civil War was the deadliest conflict in US history. However, incomplete records have made it difficult to estimate the exact death toll both nationally, and especially, at the state level. In this article, we leverage the recently released full count of individual census returns and a sample of linked records across multiple censuses to provide i) the most precise national estimate of excess mortality to date and ii) reliable state-level estimates of excess mortality among native-born whit...
• Symmetry engineering in 2D bioelectronics facilitating augmented biosensing interfaces AI翻译
  作者：Wu, Yizhang; Liu, Yihan; Li, Yuan; Wei, Ziquan; Xing, Sicheng; Wang, Yunlang; Zhu, Dashuai; Guo, Ziheng; Zhang, Anran; Yuan, Gongkai; Zhang, Zhibo; Huang, Ke; Wang, Yong; Wu, Guorong; Cheng, Ke; Bai, Wubin
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; North Carolina State University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Nanjing University; Columbia University; Michigan State University; North Carolina State University; Xidian University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：Symmetry lies at the heart of two- dimensional (2D) bioelectronics, determining material properties at the fundamental level. Breaking the symmetry allows emergent functionalities and effects. However, symmetry modulation in 2D bioelectronics and the resultant applications have been largely overlooked. Here, we devise an oxidized architectural MXene, referred to as oxidized MXene (OXene), that couples orbit symmetric breaking with inverse symmetric breaking to entitle the optimized interfacial...
• Genetic differentiation and precolonial Indigenous cultivation of hazelnut ( Corylus cornuta, Betulaceae) in Western North America AI翻译
  作者：Armstrong, Chelsey Geralda; Carvalho, Rute B. G. Clemente-; Turner, Nancy J.; Wickham, Sara; Trant, Andrew; Lemay, Matthew A.
  作者单位：Simon Fraser University; Simon Fraser University; Hakai Institute; University of Victoria; University of Waterloo
  摘要：Cultivation studies evaluating land- use histories and coevolutionary dynamics between humans and plants focus predominantly on domesticated species. Traditional anthropological divisions of foragers and farmers have shaped our understanding of ancient cultivation practices but have several limitations, including how people stewarded and managed nondomesticated species. To investigate the long- term effects of plant management in the Pacific Northwest, this study focuses on beaked hazelnut ( C...
• Unmeasured mediator- outcome confounding distorts both indirect and direct effects AI翻译
  作者：Loh, Wen Wei
  作者单位：Maastricht University
• Targeting PRMT7-mediated monomethylation of MAVS enhances antiviral innate immune responses and inhibits RNA virus replication AI翻译
  作者：Yang, Jingjing; Li, Wenjuan; Zhang, Zepeng; Gong, Xiaohua; Chen, Yanchao; Peng, Xiaoyu; Hu, Guosheng; Dai, Xianglong; He, Yaohui; Huang, Ying; Cao, Shiqiang; Yang, Yang; Liu, Wen
  作者单位：Xiamen University; Southern University of Science & Technology; Xiamen University; Fujian Medical University
  摘要：RIG- I- like receptors (RLRs)- mitochondrial antiviral signaling protein (MAVS) are crucial for type I interferon (IFN) signaling pathway and innate immune responses triggered by RNA viruses. However, the regulatory molecular mechanisms underlying RNA virus- activated type I IFN signaling pathway remain incompletely understood. Here, we found that protein arginine methyltransferase 7 (PRMT7) serves as a negative regulator of the type I IFN signaling pathway by interacting with MAVS and catalyz...
• Extensive import of nucleus- encoded tRNAs into chloroplasts of the photosynthetic lycophyte, Selaginella kraussiana AI翻译
  作者：Berrissou, Christina; Cognat, Valerie; Koechler, Sandrine; Bergdoll, Marc; Duchene, Anne- Marie; Drouard, Laurence
  作者单位：Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Centre National de la Recherche Scientifique (CNRS)
  摘要：Over the course of evolution, land plant mitochondrial genomes have lost many transfer RNA (tRNA) genes and the import of nucleus- encoded tRNAs is essential for mitochondrial protein synthesis. By contrast, plastidial genomes of photosynthetic land plants generally possess a complete set of tRNA genes and the existence of plastidial tRNA import remains a long- standing question. The early vascular plants of the Selaginella genus show an extensive loss of plastidial tRNA genes while retaining ...
• Political partisanship influences behavioral responses to governors' recommendations for COVID-19 prevention in the United States (vol 117, pg 24144, 2020) AI翻译
  作者：Grossman, Guy; Kim, Soojong; Rexer, Jonah M.; Thirumurthy, Harsha
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
• CTCF- dependent insulation of Hoxb13 and the heterochronic control of tail length AI翻译
  作者：Lopez-Delisle, Lucille; Zakany, Jozsef; Bochaton, Celia; Osteil, Pierre; Mayran, Alexandre; Darbellay, Fabrice; Mascrez, Benedicte; Rekaik, Hocine; Duboule, Denis
  作者单位：Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Geneva; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite PSL; College de France; Ecole Normale Superieure (ENS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Clermont Auvergne (UCA); Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); University of Geneva
  摘要：Mammalian tail length is controlled by several genetic determinants, among which are Hox13 genes, whose function is to terminate the body axis. Accordingly, the precise timing in the transcriptional activation of these genes may impact upon body length. two genes separated by a ca. 70 kb large DNA segment containing a high number of CTCF sites, potentially isolating Hoxb13 from the rest of the cluster and thereby delaying its negative impact on trunk extension. We deleted the spacer DNA to ind...