Proceedings of the National Academy of Sciences of the United States of America

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• Abundant fluids in southern Kumano Basin linked to fluid source and slow earthquakes at the plate boundary in the Nankai Trough AI翻译
  作者：Liu, Xin; Nakanishi, Ayako; Fujie, Gou; Tonegawa, Takashi; Nakamura, Yasuyuki; Obana, Koichiro; Kodaira, Shuichi
  作者单位：Japan Agency for Marine-Earth Science & Technology (JAMSTEC); University of Hong Kong
  摘要：The Nankai Trough is a major subduction zone in southern Japan capable of generating the next M7 or larger earthquake off Kii Peninsula. In addition to earthquakes characterized by sharp P and S arrivals, there are numerous slow earthquakes without clear P phases at the subducting plate boundary corresponding to transient slips that are related to fluids at the plate boundary and high pore pressure. In this study, we perform ambient noise differential adjoint tomography to derive the S-wave ve...
• The distortion-push mechanism for the γ subunit rotation in F1-ATPase AI翻译
  作者：Motohashi, Masahiro; Oide, Mao; Kobayashi, Chigusa; Jung, Jaewoon; Muneyuki, Eiro; Sugita, Yuji
  作者单位：Chuo University; University of Osaka; RIKEN; RIKEN
  摘要：F1-ATPase comprises the stator ring consisting of alpha 3 beta 3 subunits and the rotor gamma subunit. The gamma subunit rotation mechanism has been extensively investigated by biochemical analyses, structural studies, single-molecule measurements, and computational studies. Recent cryoelectron microscopy (cryo-EM) structures of F1-ATPase from the thermophilic bacterium Bacillus PS3 (TF1) provide us with further possibilities for a better understanding of the gamma-rotation mechanisms. Using c...
• Rare variants in BMAL1 are associated with a neurodevelopmental syndrome AI翻译
  作者：Cuddapah, Vishnu Anand; Chen, Dechun; Cho, Bumsik; Moore, Rebecca; Suri, Mohnish; Safraou, Hana; Tran-Mau-Them, Frederic; Wilson, Ashley; Odgis, Jacqueline; Rehman, Atteeq U.; Saunders, Carol; Ganesan, Shiva; Jobanputra, Vaidehi; Scherer, Stephen W.; Helbig, Ingo; Sehgal, Amita
  作者单位：Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Howard Hughes Medical Institute; University of Pennsylvania; University of Pennsylvania; Nottingham University Hospital NHS Trust; Universite Bourgogne Europe; CHU Dijon Bourgogne; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Bourgogne Europe; Icahn School of Medicine at Mount Sinai; University of Missouri System; University of Missouri Kansas City; Children's Mercy Hospital; University of Missouri System; University of Missouri Kansas City; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; NewYork-Presbyterian Hospital; Columbia University; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; University of Pennsylvania
  摘要：Through international gene- matching efforts, we identified 10 individuals with ultrarare heterozygous variants, including 5 de novo variants, in BMAL1, a core component of the molecular clock. Instead of an isolated circadian phenotype seen with disease- causing variants in other molecular clock genes, all individuals carrying BMAL1 variants surprisingly share a clinical syndrome manifest as developmental delay and autism spectrum disorder, with variably penetrant sleep disturbances, seizures...
• Evolution and evolvability of rifampicin resistance across the bacterial tree of life AI翻译
  作者：Bolourchi, Negin; Brown, Christopher R. P.; Letten, Andrew D.; Engelstaedter, Jan
  作者单位：University of Queensland
  摘要：Predicting the ability of bacteria to develop antibiotic resistance is challenging, especially for the vast majority of species for which no experimental data are available. Here, we investigated the evolvability and intrinsic presence of rifampicin resistance across the bacterial tree of life. We compiled a comprehensive panel of known rifampicin resistance mutations, comprising 57 amino acid substitutions within the gene rpoB. We then screened more than 18,000 genomes from all major bacteria...
• Nutrient-dense foods and diverse diets are important for ensuring adequate nutrition across the life course (2024; Proc. Natl. Acad. Sci. U.S.A.121 , e2319007121) AI翻译
  作者：Beal, Ty; Manohar, Swetha; Miachon, Lais; Fanzo, Jessica
• Carozza et al., Whole- brain white matter variation across childhood environments ( vol 122 ,e2409985122, 2025 ) AI翻译
  作者：Carozza, Sofia; Kletenik, Isaiah; Astle, Duncan; Schwamm, Lee; Dhand, Amar
• Photoselective isotope fractionation dynamics of N2 with cosmo and atmospheric chemistry perspectives AI翻译
  作者：Komarova, Ksenia; Gelfand, Natalia A.; Remacle, Francoise; Levine, Raphael D.; Chakraborty, Subrata; Jackson, Teresa L.; Kostko, Oleg; Thiemens, Mark H.
  作者单位：Hebrew University of Jerusalem; University of Liege; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California San Diego; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Southern California
  摘要：Stable isotope ratio measurements provide valuable insights into a broad range of natural processes, from planetary atmospheres and climate to interstellar chemistry. Nitrogen, which has two stable isotopes, exhibits varying isotope ratios across the solar system. To model these observations, the isotope fraction as a function of energy is essential. At the Advanced Light Source (ALS), we measured the photodissociation of molecular nitrogen (N2) with vacuum UV photons where a single photon is ...
• Gelated microvesicle-mediated delivery of mesenchymal stem cell mitochondria for the treatment of myocardial infarction AI翻译
  作者：Chu, Qi; He, Dong; Xie, Wenqi; Li, Shichun; Dong, Zixuan; Fu, Xiaoling
  作者单位：South China University of Technology; South China University of Technology; South China University of Technology; South China University of Technology
  摘要：Mitochondrial dysfunction is closely linked to cardiomyocyte injury following myocardial infarction (MI). While mitochondrial transplantation is a promising therapeutic strategy, challenges remain in maintaining mitochondrial structural integrity, enhancing delivery efficiency, and increasing the mitochondrial supply. Herein, we developed a gelated microvesicle-based mitochondria delivery system (Mito@Microgels) for transplanting mesenchymal stem cell mitochondria, addressing the aforementione...
• Action-mode subnetworks for decision-making, action control, and feedback AI翻译
  作者：D'Andrea, Carolina Badke; Laumann, Timothy O.; Newbold, Dillan J.; Lynch, Charles J.; Hadji, Mohammad; Nelson, Steven M.; Nielsen, Ashley N.; Chauvin, Roselyne J.; Krimmel, Samuel R.; Snyder, Abraham Z.; Marek, Scott; Greene, Deanna J.; Raichle, Marcus E.; Dosenbach, Nico U. F.; Gordon, Evan M.
  作者单位：Washington University (WUSTL); Washington University (WUSTL); University of California System; University of California San Diego; New York University; Cornell University; Weill Cornell Medicine; University of Minnesota System; University of Minnesota Twin Cities; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
  摘要：The action-mode network (AMN) is a canonical functional brain network first identified using resting-state functional connectivity (RSFC). Based on animal and human data, we have proposed that AMN supports the brain's action mode by controlling functions required for successful goal-directed behavior. However, task fMRI averaged across groups has associated AMN regions with a variety of behaviors, contributing to uncertainty about AMN function. Here, we investigated the AMN using an inside-out...
• Axonal pathology differentially affects human Purkinje cell subpopulations in the essential tremor cerebellum AI翻译
  作者：Widner, James; Faust, Phyllis L.; Louis, Elan D.; Fujita, Hirofumi
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; Columbia University; NewYork-Presbyterian Hospital; NewYork-Presbyterian Hospital; University of Texas System; University of Texas Southwestern Medical Center
  摘要：The cerebellar cortex is organized into discrete regions populated by molecularly distinct Purkinje cells (PCs), the sole cortical output neurons. While studies in animal models have shown that PC subtypes differ in their vulnerability to disease, our understanding of human PC subtype and vulnerability remains limited. Here, we demonstrate that human cerebellar regions specialized for motor vs. cognitive functions (lobule HV vs. Crus I) contain distinct PC populations characterized by specific...