Proceedings of the National Academy of Sciences of the United States of America

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• A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice AI翻译
  作者：Millera, Bradley R.; Gonzaga-Jaureguic, Claudia; Brigattie, Karlla W.; de Jonga, Job; Breeseg, Robert S.; Ko, Seungyeon; Puffenbergere, Erik G.; Van Houtc, Cristopher; Younge, Millie; Lunah, Victor M.; Staplesc, Jeffrey; First, Michael B.; Gregoirea, Hilledna J.; Dworka, Andrew J.; Pefanisg, Evangelos; Mccarthyc, Shane; Brydges, Susannah; Rojasg, Jose; Yec, Bin; Stahlc, Eli; Di Gioiac, Silvio Alessandro; Hena, Rene; Elwoodi, Kevin; Rosoklijaa, Gorazd; Lic, Dadong; Mellisg, Scott; Careyi, David; Crollg, Susan D.; Overtonc, John D.; Macdonaldg, Lynn E.; Economidesc, Aris N.; Shuldinerc, Alan R.; Chuhmaf, Nao; Rayportf, Stephen; Aminj, Najaf; Kushnera, Steven A.; Haberg, Nicole Alessandri-; Markx, Sander; Strauss, Kevin A.
  作者单位：Columbia University; New York State Psychiatry Institute; Regeneron; Universidad Nacional Autonoma de Mexico; New York State Psychiatry Institute; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Geisinger Health System; Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus MC; University of Massachusetts System; University of Massachusetts Worcester; University of Massachusetts System; University of Massachusetts Worcester
  摘要：Major depressive disorder (MDD) is a leading cause of disability worldwide. Risk for MDD is heritable, and the genetic structure of founder populations enables investigation of rare susceptibility alleles with large effect. In an extended Old Order Mennonite family cohort, we identified a rare missense variant in GPR156 (c.1599G>T, p.Glu533Asp) associated with a two-fold increase in the relative risk of MDD. GPR156 is an orphan G protein-coupled receptor localized in the medial habenula, a reg...
• Dynamic coexistence driven by physiological transitions in microbial communities AI翻译
  作者：Narla, Avaneesh V.; Hwa, Terence; Murugan, Arvind
  作者单位：University of California System; University of California San Diego; University of Chicago
  摘要：Microbial ecosystems are commonly modeled by fixed interactions between species in steady exponential growth states. However, microbes in exponential growth often modify their environments so strongly that they are forced out of the growth state into stressed, nongrowing states. Such dynamics are typical of ecological succession in nature and serial-dilution cycles in the laboratory. Here, we introduce a phenomenological model, the Community State Model, to gain insight into the dynamic coexis...
• Disrupted sensorimotor predictions in high autistic characteristics AI翻译
  作者：Pome, Antonella; Zimmermann, Eckart
  作者单位：Heinrich Heine University Dusseldorf
  摘要：Humans maintain a stable view of the world by omitting self-generated motion during rapid eye movements, or saccades. An efferent copy of the saccade motor command informs visual processing about the self-produced motion. However, efference copy information has been demonstrated to be disrupted in individuals with high autistic traits. Here, we investigated saccadic omission in participants with high vs. low autistic traits. Participants made saccades to peripheral targets and reported the loc...
• Mapping the developmental profile of ventricular zone-derived neurons in the human cerebellum AI翻译
  作者：Erickson, Anders W.; Tan, Henry; Hendrikse, Liam D.; Millman, Jake; Thomson, Zachary; Golser, Joseph; Khan, Omar; He, Guanyi; Bach, Kathleen; Mishra, Arpit Suresh; Kopic, Janja; Krsnik, Zeljka; Encha- Razavi, Ferechte; Petrilli, Giulia; Guimiot, Fabien; Silvestri, Evelina; Aldinger, Kimberly A.; Taylor, Michael D.; Millen, Kathleen J.; Haldipur, Parthiv
  作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Seattle Children's Hospital; Benaroya Research Institute; University of Zagreb; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Robert-Debre - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Azienda Ospedaliera San Camillo-Forlanini; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Texas Children's Cancer Center; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto
  摘要：The cerebellar ventricular zone (VZ) is the primary source of progenitors that generate cerebellar GABAergic neurons, including Purkinje cells (PCs) and interneurons (INs). This study provides detailed characterization of human cerebellar GABAergic neurogenesis using transcriptomic and histopathological analyses and reveals conserved and unique features compared to rodents. We show that the sequential progression of neurogenesis is conserved and occurs before 8 postconception weeks. Notably, P...
• The Beholder's Share: Bridging art and neuroscience to study individual differences in subjective experience AI翻译
  作者：Durkin, Celia; Apicella, Marc; Baldassano, Christopher; Kandel, Eric; Shohamy, Daphna
  作者单位：Columbia University; Columbia University; Columbia University
  摘要：Our experience of the world is inherently subjective, shaped by individual history, knowledge, and perspective. Art offers a framework within which this subjectivity is practiced and promoted, inviting viewers to engage in interpretation. According to art theory, different forms of art-ranging from the representational to the abstract-challenge these interpretive processes in different ways. Yet, much remains unknown about how art is subjectively interpreted. In this study, we sought to elucid...
• Perturbing nuclear glycosylation in the mouse preimplantation embryo slows down embryonic development AI翻译
  作者：Formichetti, Sara; Serrano, Joana B.; Chitnavis, Urvashi; Sadowska, Agnieszka; Liu, Na; Boskovic, Ana; Boulard, Matthieu
  摘要：The main form of intracellular protein glycosylation (O-GlcNAc) is reversible and has been mapped on thousands of cytoplasmic and nuclear proteins, including RNA polymerase II, transcription factors, and chromatin modifiers. The O-GlcNAc modification is catalyzed by a single enzyme known as O-GlcNAc Transferase, that is required for mammalian early development. Yet, neither the regulatory function of protein O-GlcNAcylation in the embryo nor the embryonic O-GlcNAc proteome have been documented...
• FLIPL permits apoptotic and inflammatory signaling and inhibits necroptosis in mice without Caspase-8 oligomerization AI翻译
  作者：Shaw, Jeremy J. P.; Guy, Cliff; Tummers, Bart; Green, Douglas R.
  作者单位：St Jude Children's Research Hospital; University of London; King's College London
  摘要：Caspase- 8 signaling has proapoptotic, antinecroptotic, and proinflammatory signaling roles dependent on interaction with the adapter molecule FADD, oligomerization, and autocleavage. Previously, a Caspase- 8 binding partner cFLIPL (FLIP, encoded by Cflar) was shown to prevent Caspase- 8- dependent apoptosis, but permit Caspase- 8- dependent inhibition of necroptosis. We sought to explore the role of FLIP in Caspase- 8- dependent apoptosis induction, necroptosis inhibition, and inflammatory si...
• Astrocytic Ryk signaling coordinates scarring and wound healing after spinal cord injury AI翻译
  作者：Shen, Zhe; Feng, Bo; Lim, Wei Ling; Woo, Timothy; Liu, Yanlin; Vicenzi, Silvia; Wang, Jingyi; Kwon, Brian K.; Zou, Yimin
  作者单位：University of California System; University of California San Diego; University of British Columbia
  摘要：Wound healing after spinal cord injury involves highly coordinated interactions among multiple cell types, which are poorly understood. Astrocytes play a central role in creating a border against the non-neural lesion core. To do so, astrocytes undergo dramatic morphological changes by first thickening and elongating their processes and then overlapping them to form a physical barrier. We show here that the expression of a cell-surface receptor, Ryk, is induced in astrocytes after injury in bo...
• The RNA- binding protein RBPMS inhibits smooth muscle cell-driven vascular remodeling in atherosclerosis and vascular injury (vol 122, e2415933122, 2025) AI翻译
  作者：Du, Jianlin; Yuan, Xin; Wang, Jiajia; Zhang, Lujun; Tan, Fangyan; Hu, Tianyang; Li, Xingsheng; Liu, Fan; Ran, Haitao; Wang, Zhigang; Li, Yongyong; Feng, Yuxing; Melgiri, N. D.; Cao, Yu; Jiang, Lihong; Huang, Rongzhong; Sun, Yang
  作者单位：Chongqing Medical University; Chongqing Medical University; Chongqing Medical University; Chongqing Medical University; Kunming University of Science & Technology; Kunming University of Science & Technology; Kunming University of Science & Technology
• Structural assembly of the PAS domain drives the catalytic activation of metazoan PASK AI翻译
  作者：Dhungel, Sajina; Xiao, Michael; Pushpabai, Rajesh Rajaian; Kikani, Chintan K.
  作者单位：Rockefeller University; University of Kentucky
  摘要：PAS domains are ubiquitous sensory modules that transduce environmental signals into cellular responses through tandem PAS folds and PAS-associated C-terminal (PAC) motifs. While this conserved architecture underpins their regulatory roles, here we uncover a structural divergence in the metazoan PAS domain-regulated kinase (PASK). By integrating evolutionary-scale domain mapping with deep learning-based structural models, we identified two PAS domains in PASK, namely PAS-B and PAS-C, in additi...