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作者：Niu, Qingfeng; Xu, Yaping; Huang, Huan; Li, Linzhu; Tang, Dengguo; Wu, Siqun; Liu, Ping; Liu, Ruie; Ma, Yu; Zhang, Bo; Zhu, Jian-Kang; Lang, Zhaobo
作者单位：Anhui Agricultural University; Southern University of Science & Technology; Southern University of Science & Technology; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; Zhejiang University
摘要：DNA methylation regulates fruit ripening in tomato, and disruption of the DNA ylation and impaired ripening. We report here that the transcription factors Ripening Inhibitor (RIN) and FRUITFULL 1 (FUL1) play critical roles in mediating the effect of DNA methylation on tomato fruit ripening. RIN and FUL1 are silenced in dml2 mutant plants, and the defective ripening phenotype of dml2 is mimicked by the rin/ ful1 double mutant. Restoration of RIN expression in dml2 partially rescues its ripening...
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作者：Qiu, Yunrui; Jang, Inhyuk; Huang, Xuhui; Yethiraj, Arun
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：Unraveling the relationship between structural information and the dynamic properties of supercooled liquids is one of the great challenges of physics. Dynamic heterogeneity, characterized by the propensity of particles, is often used as a proxy for dynamic slowing. Over the years, significant efforts have been made to capture the structural variations linked to dynamic heterogeneity in supercooled liquids. In this work, we present an innovative unsupervised machine learning protocol based on ...
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作者：Stachowski, Nicholas J.; Wheel, Jaimena H.; Singh, Shayna; Atoche, Sebastian J.; Yao, Lihua; Garcia-Ramirez, D. Leonardo; Giszter, Simon F.; Dougherty, Kimberly J.
作者单位：Drexel University
摘要：Various strategies targeting spinal locomotor circuitry have been associated with functional improvements after spinal cord injury (SCI). However, the neuronal populations mediating beneficial effects remain largely unknown. Using a combination therapy in a mouse model of complete SCI, we show that virally delivered brain-derived neurotrophic factor (BDNF) (AAV-BDNF) activates hindlimb stepping and causes hyperreflexia, whereas submotor threshold epidural stimulation (ES) reduces BDNF-induced ...
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作者：Huang, Chuanzhong; Wang, Ling; Zhuo, Changhua; Chen, Wenxin; Fan, Hongmei; Hong, Yilin; Zhang, Yu; Zhou, Dongmei; Lin, Wansong; Zhang, Lingyu; Zhao, Jingjing; Chen, Shuping; Yu, Chundong; Ye, Yunbin
作者单位：Fujian Medical University; Fujian Medical University; Xiamen University
摘要：The inhibitor of DNA binding protein ID3 has been associated with the progression of colorectal cancer (CRC). Despite its significance, its specific role in the immune evasion strategies utilized by CRC remains unclear. RNA-seq analysis revealed that ID3 was positively associated with the PD-L1 immune checkpoint. We further demonstrated that tumor cell-expressed ID3 enhanced PD-L1 expression, suppressed the infiltration and activation of CD8+T cells, and facilitated the immune evasion of CRC c...
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作者：Adam, David
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作者：Colameo, David; Maley, Sara M.; Winterer, Jochen; ElGrawani, Waleed; Gilardi, Carlotta; Galkin, Simon; Fiore, Roberto; Brown, Steven A.; Schratt, Gerhard
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich
摘要：Homeostatic synaptic plasticity (HSP) is a neuronal mechanism that allows networks to compensate for prolonged changes in activity by adjusting synaptic strength. This process is crucial for maintaining stable brain function and has been implicated in memory consolidation during sleep. While scaling of both excitatory and inhibitory synapses plays an important role during homeostatic synaptic plasticity, molecules coordinating these processes are unknown. In this study, we investigate the role...
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作者：Pitzen, Samuel P.; Rudenick, N.; Qiu, Yinjie; Zhang, Weijie; Munro, Sarah A.; Mccluskey, Braedan M.; Forster, Colleen; Bergom, Hannah E.; Ali, Atef; Boytim, Ella; Lafin, John T.; Linder, Simon; Ismail, Mazlina; Devlies, Wout; Sessions, Conner J.; Claessens, Frank; Joniau, Steven; Attard, Gerhardt; Zwart, Wilbert; Nelson, Peter S.; Corey, Eva; Wang, Yuzhuo; Lang, Joshua M.; Beltran, Himisha; Strand, Douglas; Antonarakis, Emmanuel S.; Hwang, Justin; Murugan, Paari; Huang, R. Stephanie; Dehm, Scott M.
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作者：Polasky, Stephen; Scheffer, Marten; Anderies, John M.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; Wageningen University & Research; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Royal Swedish Academy of Sciences; Beijer Institute of Ecological Economics
摘要：A well-functioning society requires well-functioning institutions that ensure prosperity, fair distribution of wealth, social participation, security, and informative media. Such institutions are built on a foundation of trust. However, while trust is essential for economic success and good governance, interconnected mechanisms inherent in weakly governed market economies tend to undermine the very trust on which such success depends. These mechanisms include the intrinsic tendency for inequal...
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作者：Vanunu, Yonatan; Newell, Ben R.
作者单位：Tel Aviv University; Tel Aviv University; University of New South Wales Sydney
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作者：Ikeda, Toma; Nojima, Tatsuya; Yamamoto, Souma; Yamada, Ryusei; Niwa, Tatsuya; Konno, Hiroki; Taguchi, Hideki
