Proceedings of the National Academy of Sciences of the United States of America

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• Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury AI翻译
  作者：Koh, Yeojung; Vazquez-Rosa, Edwin; Gao, Farrah; Li, Hongyun; Chakraborty, Suwarna; Tripathi, Sunil Jamuna; Barker, Sarah; Bud, Zea; Bangalore, Anusha; Kandjoze, Uapingena P.; Leon-Alvarado, Rose A.; Sridharan, Preethy S.; Cordova, Brittany A.; Yu, Youngmin; Hyung, Jiwon; Fang, Hua; Singh, Salendra; Katabathula, Ramachandra; LaFramboise, Thomas; Kasturi, Lakshmi; Lutterbaugh, James; Beard, Lydia; Cordova, Erika; Cintron-Perez, Coral J.; Franke, Kathryn; Fragoso, Mariana Franco; Miller, Emiko; Indrakumar, Vidya; Noel, Kamryn L.; Dhar, Matasha; Ajroud, Kaouther; Zamudio, Carlos; Tavares Pereira Lopes, Filipa Blasco; Bambakidis, Evangeline; Zhu, Xiongwei; Wilson, Brigid; Flanagan, Margaret E.; Gefen, Tamar; Fujioka, Hisashi; Fink, Stephen P.; Desai, Amar B.; Dawson, Dawn; Williams, Noelle S.; Kim, Young-Kwang; Ready, Joseph M.; Paul, Bindu D.; Shin, Min-Kyoo; Markowitz, Sanford D.; Pieper, Andrew A.
  作者单位：University System of Ohio; Case Western Reserve University; University Hospitals of Cleveland; Geriatric Research Education & Clinical Center; University System of Ohio; Case Western Reserve University; US Department of Veterans Affairs; Veterans Health Administration (VHA); Louis Stokes Cleveland Veterans Affairs Medical Center; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; Johns Hopkins University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; Earlham College; University System of Ohio; University of Toledo; Massachusetts Institute of Technology (MIT); Cleveland Clinic Foundation; University System of Ohio; Case Western Reserve University; Northwestern University; Feinberg School of Medicine; Northwestern University; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University; Northwestern University; University System of Ohio; Case Western Reserve University; University of Texas System; University of Texas at San Antonio; Northwestern University; Feinberg School of Medicine; University System of Ohio; Case Western Reserve University; University of Texas System; University of Texas Southwestern Medical Center; Seoul National University (SNU); Seoul National University (SNU); Johns Hopkins University; Johns Hopkins University; Seoul National University (SNU); University Hospitals of Cleveland
  摘要：Alzheimer's disease (AD) and traumatic brain injury (TBI) are currently untreatable neurodegenerative disorders afflicting millions of people worldwide. These conditions are pathologically related, and TBI is one of the greatest risk factors for AD. Although blood-brain barrier (BBB) disruption drives progression of both AD and TBI, strategies to preserve BBB integrity have been hindered by lack of actionable targets. Here, we identify 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an enzyme...
• Controlling impact mitigation via Bouligand nanostructures AI翻译
  作者：Lee, Sujin R.; Evans, Katherine M.; Woodcock, Jeremiah W.; Obrzut, Jan; Huang, Liping; Soles, Christopher L.; Chan, Edwin P.
  作者单位：National Institute of Standards & Technology (NIST) - USA; Rensselaer Polytechnic Institute
  摘要：Critical to their survival, natural organisms have developed exoskeletons that can withstand and inflict damage over their lifetime. The Bouligand structure of the exoskeleton plays a key role in toughness and damage resistance under external impacts. Numerous studies have investigated the morphology of Bouligands and their mechanical properties, yet understanding their structure-function relationship remains challenging due to the complex mechanical responses of biological materials and the l...
• A prolactin- targeting antibody to prevent stress- induced peripheral nociceptor sensitization and female postoperative pain AI翻译
  作者：Stratton, Harrison J.; Dolatyari, Mahdi; Kopruszinski, Carol; Ghetti, Andre; Maciuba, Stephanie; Bowden, Greg; Riviere, Pierre; Barber, Kara; Dodick, David W.; Edorh, Edel; Dumaire, Nicolas; Moutal, Aubin; Navratilova, Edita; Porreca, Frank
  作者单位：University of Arizona; Saint Louis University
  摘要：Scheduled surgeries elicit stress in many patients. Levels of preoperative stress, anxiety, and female gender are known risk factors for increased and prolonged postoperative pain. The mechanisms by which psychological stress increases postoperative pain, especially in women, remain unknown. We hypothesized that stress amplifies postoperative pain by sensitizing dorsal root ganglion (DRG) nociceptors. Prolactin (PRL) is a female-predominant neurohormone that is controlled by estrogen and stres...
• Diversity statistics of onomastic data reveal social patterns in Hebrew Kingdoms of the Iron Age AI翻译
  作者：Vishne, Ariel; Golub, Mitka R.; Piasetzky, Eli; Finkelstein, Israel; Sober, Barak
  作者单位：Hebrew University of Jerusalem; Hebrew University of Jerusalem; Tel Aviv University; University of Haifa; Hebrew University of Jerusalem
  摘要：The distribution of personal names provides unique, yet often overlooked, insight into modern and historical societies. This study employs diversity statistics-commonly used in ecology-to analyze onomastic data from Iron Age II archaeological excavations in the Southern Levant (950-586 BCE). Our findings reveal higher onomastic diversity in the Kingdom of Israel compared to Judah, suggesting a more cosmopolitan society. We also observe a decrease in name diversity in Judah over time, potential...
• Theory and observations of the interaction between magnetohydrodynamic waves and shocks AI翻译
  作者：Zhao, Lingling; Zhu, Xingyu; Silwal, Ashok; Zank, Gary P.; Pitna, Alexander
  作者单位：University of Alabama System; University of Alabama Huntsville; University of Alabama System; University of Alabama Huntsville; Charles University Prague
  摘要：The interaction between interplanetary shocks or planetary bow shock and upstream magnetohydrodynamics (MHD) waves (hereafter referred to as wave-shock interactions) is of fundamental importance to plasma physics. Linear waves and shocks, which are supported by MHD framework, are ubiquitous in almost all plasma environments. A thorough understanding of the interaction between linear waves and shocks is useful not only for heliophysics and astrophysics but also for other applications such as in...
• Hygrometrically controlled programmed cell death drives anther opening and pollen release AI翻译
  作者：Kampova, Anna; Nowack, Moritz K.; Fendrych, Matyas; Vosolsobe, Stanislav
  作者单位：Charles University Prague; Ghent University; Flanders Institute for Biotechnology (VIB)
  摘要：Anther dehiscence is the process that facilitates pollen release from mature anthers in flowering plants. Despite its crucial importance to reproduction, the underlying developmental mechanism and its integration with environmental cues remain poorly understood. Establishing noninvasive, controlled humidity treatments ofArabidopsis thaliana flowers, we show here that high humidity prevents anthers from opening. Manipulation of stomatal densities alters dehiscence dynamics, suggesting a contrib...
• Lateral jaw motion in fish expands the functional repertoire of vertebrates and underpins the success of a dominant herbivore lineage AI翻译
  作者：Mihalitsis, Michalis; Yamhure-Ramirez, Denise; Beil, Maelan H.; Chan, Howan; Cole, Nathan J.; Luenenborg, Ava; Paglione, Isabella; Petri, Hallee; Shum, Nicole C.; Wainwright, Dylan K.; Zheng, Bryson; Wainwright, Peter C.
  作者单位：University of California System; University of California Davis; University of Guam; Rice University; Purdue University System; Purdue University; Purdue University System; Purdue University
  摘要：The primary function of the vertebrate jaw is the dorsoventral movement that occurs during opening and closing. Yet, several lineages have evolved the ability to move their jaws laterally, enabling major innovations, like chewing. While lateral jaw motions are primarily known in tetrapods, here, we show that an ecologically dominant lineage of reef fishes (Zanclidae and Acanthuridae) has evolved the ability to laterally rotate their jaws during feeding. This unique function substantially expan...
• Structure and nucleic acid interactions of the SΔ60 domain of the hepatitis delta virus small antigen AI翻译
  作者：Yang, Yang; Delcourte, Loic; van Belleghem, Carolanne; Fonte, Simone; Gerard, Kassandra; Baconnais, Sonia; Callon, Morgane; Le Cam, Eric; Fogeron, Marie-Laure; Levrero, Massimo; Faivre-Moskalenko, Cendrine; Bockmann, Anja; Lecoq, Lauriane
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Ecole Normale Superieure de Lyon (ENS de LYON); CHU Lyon; Universite Claude Bernard Lyon 1
  摘要：Infection with hepatitis delta virus (HDV) causes the most severe form of viral hepatitis, affecting more than 15 million people worldwide. HDV is a small RNA satellite virus of the hepatitis B virus (HBV) that relies on the HBV envelope for viral particle assembly. The only specific HDV component is the ribonucleoprotein (RNP), which consists of viral RNA (vRNA) associated with the small (S) and large (L) delta antigens (HDAg). While the structure of the HDAg N-terminal assembly domain is kno...
• RAD52's active form is not a ring AI翻译
  作者：Borgstahl, Gloria E. O.
  作者单位：University of Nebraska System; University of Nebraska Medical Center
• Behavioral resilience via dynamic circuit firing homeostasis AI翻译
  作者：Hoagland, Adam; Schultz, Ryan; Cai, Zerong; Newman, Zachary L.; Isacoff, Ehud Y.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Homeostatic regulation ensures stable neural circuit output under changing conditions. We find that in Drosophila larvae, either presynaptic weakening due to perturbation of transmitter release or postsynaptic weakening due to perturbation of glutamate receptors at synapses between motor neuron (MN) and muscle has little impact on locomotion, suggesting a nonsynaptic compensatory mechanism. In vivo imaging shows that five different forms of synaptic weakening increase the duration of activity ...