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作者：Karakas, Danielle; Li, June; Ma, Wenjing; Wu, Xun Grace; Khoury, Christopher J.; Masoud, Mina; Hoard, Brock; Liu, Yuning Jay; Zhu, Guangheng; Chen, Junmei; Sim, Martha; Shen, Chuanbin; MacParland, Sonya A.; Lopez, Jose A.; Kahr, Walter H. A.; Ni, Heyu
作者单位：University of Toronto; University of Toronto; Saint Michaels Hospital Toronto; University of Toronto; Canadian Blood Services; University of Washington; University of Washington Seattle; Ocean University of China; University of Toronto; University Health Network Toronto; University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto
摘要：Thrombopoietin (TPO), predominantly produced by the liver, is the key regulator for platelet production and the hematopoietic stem cell niche. Our earlier report demonstrated that platelet GPIb alpha is required for hepatocellular TPO generation, which is the major resource of TPO in the blood circulation. However, how hepatocytes physically contact circulating sinusoidal platelets across the liver endothelium for this process is unknown. Kupffer cells reside in contact with both sinusoidal bl...
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作者：Yao, McKenna Loop; Zill, Nicholas A.; Barber, Colin Charles; Du, Yongle; Lin, Peijun; Zhai, Rui; Yoon, Eunice; Al Marzooqi, Dunya; Zhang, Wenjun
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作者：Yoshida, Aiko; Uekusa, Yoshitsugu; Suzuki, Takeshi; Bauer, Michael; Sakai, Nobuaki; Yamauchi, Yohei
作者单位：Novo Nordisk; Hokkaido University; Olympus Corporation; Nagoya University; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; University of Bristol; University of West England
摘要：Influenza A virus (IAV) entry into host cells begins with interactions between the viral envelope proteins hemagglutinin (HA)/neuraminidase (NA) and sialic acid moieties on the cell plasma membrane. These interactions drive IAV's lateral diffusion along the cell membrane and trigger membrane morphological changes required for endocytosis. However, directly visualizing these dynamic processes, which are crucial for IAV entry, has been challenging using conventional microscopy techniques. In thi...
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作者：Pizzamiglio, Lara; Morice, Elise; Cardoso, Cecile; Bossi, Simon; Mailhes-Hamon, Caroline; von Heimendahl, Moritz; Girardeau, Gabrielle; Paoletti, Pierre
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm)
摘要：Excitatory glycine receptors (eGlyRs), composed of the glycine-binding NMDA receptor subunits GluN1 and GluN3A, have recently emerged as a novel neuronal signaling modality that challenges the traditional view of glycine as an inhibitory neurotransmitter. Unlike conventional GluN1/GluN2 NMDARs, the distribution and role of eGlyRs remain poorly understood. Here, we show that eGlyRs are highly enriched in the ventral hippocampus (VH) and confer distinct properties on this brain region. eGlyRs di...
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作者：Vosshall, Leslie B.
作者单位：Howard Hughes Medical Institute; Rockefeller University; Rockefeller University
摘要：Scientists can contribute to society in numerous ways. Some scientists discover new biological principles and found entirely new fields. Some scientists are inspiring mentors and create the next generation of inclusive lab leaders. Some scientists are entrepreneurs who develop clinically effective therapeutics. Some scientists are trusted advisors to government and pharmaceutical companies. Some scientists are visionary institutional leaders who build new departments. From this menu of activit...
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作者：Adelmann, Charles H.; Venkatachalam, Avanthika; Huang, Lingjuan; Liu, Michelle; Germana, Sharon; Harry, Stefan A.; Rosen, Paul C.; Herron, Joshua; Tien, Pei- Chieh; Bar-Peled, Liron; Sabatini, David M.; Fisher, David E.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences
摘要：While it has been appreciated for decades that lysosomes can import cysteine, its significance for whole- organism physiology has remained uncertain. Recent work identified MFSD12 as a transmembrane protein required for cysteine import into lysosomes (and melanosomes), enabling genetic interrogation of this pathway. Here, we show that Mfsd12 knockout mice die between embryonic days 10.5 and 12.5, indicating that MFSD12 is essential for organogenesis. Mfsd12 loss results in the expression of ge...
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作者：Rowntree, Louise C.; Allen, Lilith F.; Hagen, Ruth R.; McQuilten, Hayley A.; Quadeer, Ahmed A.; Chaurasia, Priyanka; Kaewpreedee, Prathanporn; Lee, Kelly W. K.; Cohen, Carolyn A.; Petersen, Jan; Littler, Dene R.; Habel, Jennifer R.; Zhang, Wuji; Cheng, Samuel M. S.; Chan, Ken Ka Pang; Kwok, Janette S. Y.; Leung, Kathy S. M.; Wu, Joseph T.; Lee, Cheuk-Kwong; Davies, Jane; Pannaraj, Pia S.; Allen, E. Kaity; Thomas, Paul G.; Tosif, Shidan; Crawford, Nigel W.; Lappas, Martha; Thevarajan, Irani; Lewin, Sharon R.; Kent, Stephen J.; Juno, Jennifer A.; Bond, Katherine A.; Williamson, Deborah A.; Holmes, Natasha E.; Smibert, Olivia C.; Gordon, Claire L.; Trubiano, Jason A.; Kotsimbos, Tom C.; Cheng, Allen C.; Efstathiou, Claudia; Turtle, Lance; Thwaites, Ryan S.; Brightling, Christopher E.; Rossjohn, Jamie; McKay, Matthew R.; Tian, Jinmin; Liu, William Jun; Gao, George Fu; Xu, Jianqing; Sonehara, Kyuto; Ishii, Ken J.; Namkoong, Ho; Okada, Yukinori; Peiris, Malik; Hui, David S. C.; Poon, Leo L. M.; Doherty, Peter C.; Nguyen, Thi H. O.; Valkenburg, Sophie A.; Kedzierska, Katherine
作者单位：University of Melbourne; Peter Doherty Institute; Hong Kong University of Science & Technology; University of Melbourne; Monash University; Monash University; University of Hong Kong; HKU Pasteur Research Pole; University of Hong Kong; Prince of Wales Hospital Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; University of Hong Kong; University of Hong Kong; University of Hong Kong; Charles Darwin University; Menzies School of Health Research; Children's Hospital Los Angeles; University of California System; University of California Los Angeles; St Jude Children's Research Hospital; Murdoch Children's Research Institute; University of Melbourne; Royal Children's Hospital Melbourne; Royal Children's Hospital Melbourne; University of Melbourne; University of Melbourne; Peter Doherty Institute; Melbourne Health; University of Melbourne; Royal Melbourne Hospital; Peter Doherty Institute; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Monash University; University of Melbourne; Alfred Health; Monash University; Melbourne Sexual Health Centre; Victorian Infectious Diseases Reference Laboratory; University of Melbourne; Peter Doherty Institute; Melbourne Health; Royal Melbourne Hospital; University of St Andrews; Florey Institute of Neuroscience & Mental Health; Austin Research Institute; Howard Florey Institute Affiliates; Austin Research Institute; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; University of Melbourne; Florey Institute of Neuroscience & Mental Health; Austin Research Institute; Howard Florey Institute Affiliates; Peter Maccallum Cancer Center; Peter Maccallum Cancer Center; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Monash University; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Monash Medical Centre; Monash University; Monash Health; Monash University; Monash University; Imperial College London; University of Liverpool; University of Leicester; Cardiff University; Chinese Center for Disease Control & Prevention; National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control & Prevention; Fudan University; Fudan University; University of Osaka; University of Tokyo; University of Tokyo; University of Osaka; Keio University; RIKEN; University of Osaka; Hokkaido University
摘要：Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in nonhospitalized individuals of European ancestry, with protective immunity attributed to preexisting cross-reactive CD8(+) T-cells directed against HLA-B*15:01-restricted Spike-derived S919-927 peptide (B15/S(919)(+)CD8(+) T-cells). However, fundamental questi...
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作者：Yao, Ze-Fan; Lim, Sujeung; Kuang, Yuyao; Lundqvist, Emil M.; Celt, Natalie; Chung, Caleb O.; Lee, Kathryn K.; Nguyen, Krystal; Le, Lanie; Tang, Sheng Wei; Milligan, Griffin M.; Kohl, Phillip; Sudarshan, Tarunya Rao; Li, Youli; Eguchi, Asuka; Paravastu, Anant K.; Zaragoza, Michael V.; Fishman, Dmitry A.; Ardona, Herdeline Ann M.
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Santa Barbara; University System of Georgia; Georgia Institute of Technology; University of California System; University of California Irvine; University of California System; University of California Irvine; University System of Georgia; Georgia Institute of Technology
摘要：Charge and energy transport within living systems are fundamental processes that enable the autonomous function of excitable cells and tissues. To date, localized control of these transport processes has been enabled by genetic modification approaches to render light sensitivity to cells. Here, we present peptidic nanoassemblies as constituents of a cardiac biomaterial platform that leverages complementary sequence interactions to direct photoinduced energy transport at the cellular interface....
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作者：Aprili, Cecile; Coupier, Gwennou; Lorenceau, Elise; Dollet, Benjamin
作者单位：Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
摘要：Aqueous foams are solid materials composed of gases and liquids, exhibiting a large gas/liquid surface area and enabling dynamic exchanges between their fluid components. The structure of binary-gas foams, whose bubbles consist of a mixture of two gases having different affinities with the liquid, thus offers real potential for the dynamic separation of these gases at low cost. In single-gas foams, the structure evolves under the effect of gas flow induced by Laplace pressure differences, aris...
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作者：Faught, Erin; Schaaf, Marcel J. M.
作者单位：Leiden University - Excl LUMC; Leiden University; Radboud University Nijmegen
摘要：It is well established that stress generally suppresses immunity. However, under certain conditions, acute stress has been shown to stimulate the immune system, particularly those at barrier surfaces like the skin. The cellular and molecular mechanisms underlying this effect remain poorly understood. In the present study, we have identified an immune-enhancing effect of stress using zebrafish larvae. The use of this animal model allowed us to visualize the redistribution of macrophages to the ...
