Proceedings of the National Academy of Sciences of the United States of America

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• Invariant HVC size in female canaries singing under testosterone: Unlocking function through neural differentiation, not growth AI翻译
  作者：Ma, Shouwen; Frankl-Vilches, Carolina; Gahr, Manfred
  摘要：Testosterone administration to nonsinging adult female canaries induces song, making this a model for behavioral plasticity and its underlying neural mechanisms in vertebrates. The song control nucleus HVC is traditionally believed to undergo a substantial size change when transitioning from a nonfunctional to a functional (song-producing) state. Using 2-photon in vivo imaging, we tracked the spatial distribution and anatomical properties of HVC neurons over several weeks of testosterone-induc...
• Turning mass support for environmental goals into action AI翻译
  作者：Bouman, Thijs
  作者单位：University of Groningen
• Graph neural networks for predicting metal-ligand coordination of transition metal complexes AI翻译
  作者：Toney, Jacob W.; St Michel, Roland G.; Garrison, Aaron G.; Kevlishvili, Ilia; Kulik, Heather J.; Schatz, George
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：High-throughput virtual screening campaigns are invaluable for surveying the combinatorial space of possible transition metal complexes (TMCs), but they rely on accurate metal-ligand connectivity for meaningful results. Here, we curate a dataset of 70,069 unique ligands of known coordination from experimental structures of TMCs deposited in the Cambridge Structural Database. Using this dataset, we train separate graph neural network models to predict the total number and individual identities ...
• The intrinsic neuronal network of the central nervous system and its modular (subsystem) architecture in a mammal AI翻译
  作者：Swanson, Larry W.; Hahn, Joel D.; Sporns, Olaf
  作者单位：University of Southern California; Indiana University System; Indiana University Bloomington
  摘要：The vertebrate central nervous system (CNS) has two great topographic divisions-brain and spinal cord-that together integrate the body's internal physiology and behavioral interactions with the environment. To clarify the architecture of intra-CNS connectivity supporting this integration in a mammal (rat), network science analyses were applied at the level of gray matter regions (nodes) connected by directed and weighted axonal projections. Neuroanatomical evidence indicates a bilateral, predo...
• Muscle-specific increased expression of JAG1 improves the skeletal muscle phenotype in dystrophin-deficient mice AI翻译
  作者：de Souza Leite, Felipe; Lambert, Matthias R.; Zhang, Tracy Yuanfan; Conner, James R.; Paulo, Joao A.; Furtado Oliveira, Sheldon; Thakurta, Sanjukta Guha; Bowles, Jennifer; Gussoni, Emanuela; Gygi, Steven P.; Widrick, Jeffrey J.; Kunkel, Louis M.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
  摘要：Therapeutic strategies for Duchenne muscular dystrophy (DMD) will likely require complementary approaches. One possibility is to explore genetic modifiers that improve muscle regeneration and function. The beneficial effects of the overexpression of Jagged-1 were described in escaper golden retriever muscular dystrophy (GRMD) dogs that had a near-normal life and validated in dystrophin-deficient zebrafish. To clarify the underlying biology of JAG1 overexpression in dystrophic muscles, we gener...
• Severe water crisis in southern Spain under expanding irrigated agriculture: A multidimensional drought analysis AI翻译
  作者：Junquera, Victoria; Hormaza, Jose I.; Rubenstein, Daniel I.; Levin, Simon A.; Perez, Inaki Vadillo; Gavilan, Pablo Jimenez
  作者单位：University of Bern; Princeton University; Princeton University; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad de Malaga; CSIC-UMA - Instituto de Hortofruticultura Subtropical y Mediterranea La Mayora (IHSM); Universidad de Malaga
  摘要：The Axarqu & iacute;a region in southern Spain, a hotspot of avocado and mango production in Europe, underwent an extreme water crisis in 2019-2024. Reservoir levels dropped below the 8% outlet threshold and groundwater in the main aquifer dropped to sea level in several locations, risking seawater intrusion. Socioeconomic impacts ranged from substantial crop losses to a potential long-term decline in regional economic viability. We examine the main drivers of this crisis using a coupled human...
• Targeting endothelial ERG to mitigate vascular regression in retinopathies AI翻译
  作者：Ma, Eric; Schafer, Christopher M.; Xie, Jun; Rudenko, Yelyzaveta; Knapp, John T. H.; Randi, Anna M.; Birdsey, Graeme M.; Griffin, Courtney T.
  作者单位：Oklahoma Medical Research Foundation; Imperial College London; University of Oklahoma System; University of Oklahoma - Norman; University of Oklahoma Health Sciences Center; University of Central Oklahoma
  摘要：Retinopathy of prematurity (ROP) and diabetic retinopathy (DR) are ocular disorders in which an initial loss of retinal capillaries leads to damaging tissue ischemia followed by a compensatory neovascularization response that generates pathological capillaries in the eye. Using a mouse model of ROP and samples from DR patients, we found that the highly homologous and homeostatic erythroblast transformation-specific (ETS) family transcription factors ETS-related gene (ERG) and Friend leukemia i...
• Reply to Fleming: Not a gossamer web AI翻译
  作者：Santer, Benjamin D.; Solomon, Susan; Thompson, David W. J.; Fu, Qiang; Li, Yaowei
  作者单位：Woods Hole Oceanographic Institution; University of East Anglia; Massachusetts Institute of Technology (MIT); Colorado State University System; Colorado State University Fort Collins; University of Washington; University of Washington Seattle
• CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma AI翻译
  作者：Yang, Wu; Wang, Siying; Ji, Shuyi; Wang, Jian; Lian, Shuo; Li, Zhe; Jansen, Robin A.; Wu, Wei; Niu, Kongyan; Sun, Zhen; Jia, Qi; Zheng, Jiaojiao; Zhu, Huijue; Deng, Xuan; Wang, Liqin; Fan, Zhoulong; Shi, Yaoping; Lieftink, Cor; Guan, Ming; Beijersbergen, Roderick L.; Qin, Wenxin; Gao, Qiang; Bernards, Rene; Jin, Haojie
  作者单位：Shanghai Jiao Tong University; Netherlands Cancer Institute; Tongji University; Tongji University; Fudan University; Fudan University; Sun Yat Sen University; State Key Lab Oncology South China; Shanghai Jiao Tong University; Shanghai Jiao Tong University
  摘要：Cholangiocarcinoma (CCA) remains a lethal malignancy with limited therapeutic options. Through genome-wide CRISPR-Cas9 screening, we identified the adenosine triphosphatase (ATPase) valosin-containing protein (VCP) as a critical dependency in CCA. Compound screens revealed that the VCP inhibitor CB-5339 potently suppresses CCA proliferation in a panel of patient-derived organoids by inducing cellular senescence. It is known that senescent cells persist, and this can contribute to therapy resis...
• Earliest evidence of smoke-dried mummification: More than 10,000 years ago in southern China and Southeast Asia AI翻译
  作者：Hung, Hsiao-chun; Deng, Zhenhua; Liu, Yiheng; Ran, Zhiyu; Zhang, Yue; Li, Zhen; Kaifu, Yousuke; Huang, Qiang; Nguyen, Khanh Trung Kien; Le, Hai Dang; Xie, Guangmao; Nguyen, Anh Tuan; Yamagata, Mariko; Simanjuntak, Truman; Noerwidi, Sofwan; Fauzi, Mohammad Ruly; Tolla, Marlin; Wetipo, Alpius; He, Gang; Sawada, Junmei; Zhang, Chi; Bellwood, Peter; Matsumura, Hirofumi
  作者单位：Australian National University; Peking University; Peking University; University of Tokyo; Guangxi Normal University; Rikkyo University; National Research & Innovation Agency of Indonesia (BRIN); Niigata University of Health & Welfare; Australian National University; Sapporo Medical University
  摘要：In southern China and Southeast Asia (collectively, Southeastern Asia), Terminal Pleistocene and Early to Middle Holocene (ca. 12,000 to 4,000 cal. BP) hunter-gatherer burials feature tightly crouched or squatting postures, sometimes with indications of post-mortem dismemberment. Such burials contrast strongly with the extended supine burial postures typical of subsequent Neolithic inhumations in these regions. Their contorted postures, often with traces of burning, present interpretive challe...