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作者：Crew, Bec; Maxwell, Tanner
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作者：Kozlov, Max
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作者：Pearson, Helen
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作者：Hurley, James H.; Coyne, Alyssa N.; Miaczynska, Marta; Stenmark, Harald
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Johns Hopkins University; Johns Hopkins University; Miedzynarodowy Instytut Biologii Molekularnej i Komorkowej; University of Oslo; University of Oslo
摘要：The endosomal sorting complex required for transport (ESCRT) is a multicomplex machinery comprising proteins that are conserved from bacteria to humans and has diverse roles in regulating the dynamics of cellular membranes. ESCRT functions have far-reaching consequences for cell biological processes such as intracellular traffic, membrane repair, cell signalling, metabolic regulation, cell division and genome maintenance. Here we review recent insights that emphasize the pathophysiological con...
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作者：Kavuri, Gautam A.; Palfree, Jasper; Reddy, Dileep V.; Zhang, Yanbao; Bienfang, Joshua C.; Mazurek, Michael D.; Alhejji, Mohammad A.; Siddiqui, Aliza U.; Cavanagh, Joseph M.; Dalal, Aagam; Abellan, Carlos; Amaya, Waldimar; Mitchell, Morgan W.; Stange, Katherine E.; Beale, Paul D.; Brandao, Luis T. A. N.; Booth, Harold; Peralta, Rene; Nam, Sae Woo; Mirin, Richard P.; Stevens, Martin J.; Knill, Emanuel; Shalm, Lynden K.
作者单位：University of Colorado System; University of Colorado Boulder; National Institute of Standards & Technology (NIST) - USA; United States Department of Energy (DOE); Oak Ridge National Laboratory; University System of Maryland; University of Maryland College Park; National Institute of Standards & Technology (NIST) - USA; University of New Mexico; University of Colorado System; University of Colorado Boulder; Barcelona Institute of Science & Technology; Universitat Politecnica de Catalunya; Institut de Ciencies Fotoniques (ICFO); ICREA; University of Colorado System; University of Colorado Boulder; National Institute of Standards & Technology (NIST) - USA; University of Colorado System; University of Colorado Boulder; National Institute of Standards & Technology (NIST) - USA; University of Colorado System; University of Colorado Boulder; University of California System; University of California Berkeley
摘要：The unpredictability of random numbers is fundamental to both digital security1,2 and applications that fairly distribute resources3,4. However, existing random number generators have limitations-the generation processes cannot be fully traced, audited and certified to be unpredictable. The algorithmic steps used in pseudorandom number generators5 are auditable, but they cannot guarantee that their outputs were a priori unpredictable given knowledge of the initial seed. Device-independent quan...
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作者：Dreyer, Jacob
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作者：Ellis, Erle C.; Malhi, Yadvinder; Ritchie, Hannah; Montana, Jasper; Diaz, Sandra; Obura, David; Clayton, Susan; Leach, Melissa; Pereira, Laura; Marris, Emma; Muthukrishna, Michael; Fu, Bojie; Frankopan, Peter; Grace, Molly K.; Barzin, Samira; Watene, Krushil; Depsky, Nicholas; Pasanen, Josefin; Conceicao, Pedro
作者单位：University System of Maryland; University of Maryland Baltimore County; University of Oxford; University of Oxford; University of Oxford; Australian National University; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); National University of Cordoba; University System of Ohio; College of Wooster; University of Cambridge; University of Cambridge; University of Witwatersrand; Stockholm University; University of London; London School Economics & Political Science; University of London; London School Economics & Political Science; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; University of Oxford; University of Oxford; University of Auckland
摘要：Prevailing frameworks to address planetary environmental challenges tend to focus on setting goals, targets, or boundaries to limit human harm to ecosystems or species. Here we propose an aspirational approach aimed at empowering people to shape a better future for all of life on Earth. We do this by building on the human development approach and its supporting metrics, especially the Human Development Index (HDI), a broadly influential framework that has contributed to decades of human progre...
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作者：McGranahan, Nicholas; Roychoudhuri, Rahul
作者单位：University of London; University College London; University of Cambridge
摘要：Prognosis is poor for tumours with Y-chromosome loss. Examining the interplay between cancer and immune cells sheds light on potential mechanisms.
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作者：Leeke, Bryony J.; Varsally, Wazeer; Ogushi, Sugako; Zohren, Jasmin; Menchero, Sergio; Courtois, Aurelien; Snell, Daniel M.; Teissandier, Aurelie; Ojarikre, Obah; Mahadevaiah, Shantha K.; Decarpentrie, Fanny; Oakey, Rebecca J.; VandeBerg, John L.; Turner, James M. A.
作者单位：Francis Crick Institute; Imperial College London; Francis Crick Institute; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite PSL; UNICANCER; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Novartis; University of London; King's College London; University of Texas System; University of Texas Rio Grande Valley; University of Texas System; University of Texas Rio Grande Valley
摘要：Based on seminal work in placental species (eutherians)1, 2, 3, 4, 5, 6, 7, 8, 9-10, a paradigm of mammalian development has emerged wherein the genome-wide erasure of parental DNA methylation is required for embryogenesis. Whether such DNA methylation reprogramming is, in fact, conserved in other mammals is unknown. Here, to resolve this point, we generated base-resolution DNA methylation maps in gametes, embryos and adult tissues of a marsupial, the opossum Monodelphis domestica, revealing v...
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作者：Bradley, James; Crow, James Mitchell
作者单位：Aix-Marseille Universite
