The expanding repertoire of ESCRT functions in cell biology and disease

• 成果类型: Review
• 署名作者: Hurley, James H.; Coyne, Alyssa N.; Miaczynska, Marta; Stenmark, Harald
• 署名单位: University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Johns Hopkins University; Johns Hopkins University; Miedzynarodowy Instytut Biologii Molekularnej i Komorkowej; University of Oslo; University of Oslo
• 刊物名称: Nature
• ISSN/ISSBN: 0028-2146
• DOI: 10.1038/s41586-025-08950-y
• 发表日期: 2025-06-26
• 页码: 877-888
• 关键词: frontotemporal dementia; nucleocytoplasmic transport; membrane scission; sorting complex; hiv-1 p6; protein; tsg101; mutations; chmp2b; machinery

摘要

The endosomal sorting complex required for transport (ESCRT) is a multicomplex machinery comprising proteins that are conserved from bacteria to humans and has diverse roles in regulating the dynamics of cellular membranes. ESCRT functions have far-reaching consequences for cell biological processes such as intracellular traffic, membrane repair, cell signalling, metabolic regulation, cell division and genome maintenance. Here we review recent insights that emphasize the pathophysiological consequences of ESCRT dysfunctions, including infections, immune disorders, cancers and neurological diseases. We highlight the possibilities of using our knowledge about ESCRT structures and functions for drug discovery.