Nature

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• Brain implantation of soft bioelectronics via embryonic development AI翻译
  作者：Sheng, Hao; Liu, Ren; Li, Qiang; Lin, Zuwan; He, Yichun; Blum, Thomas S.; Zhao, Hao; Tang, Xin; Wang, Wenbo; Jin, Lishuai; Wang, Zheliang; Hsiao, Emma; Le Floch, Paul; Shen, Hao; Lee, Ariel J.; Jonas-Closs, Rachael Alice; Briggs, James; Liu, Siyi; Solomon, Daniel; Wang, Xiao; Whited, Jessica L.; Lu, Nanshu; Liu, Jia
  作者单位：Harvard University; Harvard University; University of Pennsylvania; University of Texas System; University of Texas Austin; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Harvard University
  摘要：Developing bioelectronics capable of stably tracking brain-wide, single-cell, millisecond-resolved neural activity in the developing brain is critical for advancing neuroscience and understanding neurodevelopmental disorders. During development, the three-dimensional structure of the vertebrate brain arises from a two-dimensional neural plate1,2. These large morphological changes have previously posed a challenge for implantable bioelectronics to reliably track neural activity throughout brain...
• Science Inc. AI翻译
  作者：Crew, Bec
• What incentives do companies need to publish research? AI翻译
  作者：Owens, Brian
• Two distinct host-specialized fungal species cause white-nose disease in bats AI翻译
  作者：Fischer, Nicola M.; Dumville, Imogen; Nabholz, Benoit; Zhelyazkova, Violeta; Stecker, Ruth-Marie; Blomberg, Anna S.; Dool, Serena E.; Fritze, Marcus; Tilak, Marie-Ka; Bashta, Andriy-Taras; Chenal, Clothilde; Fiston-Lavier, Anna-Sophie; Puechmaille, Sebastien J.
  作者单位：Universitat Greifswald; Institut de Recherche pour le Developpement (IRD); Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Institut Universitaire de France; Bulgarian Academy of Sciences; University of Turku; University of Helsinki; CIRAD; Institut Agro; INRAE; Universite de Montpellier; Universite de Montpellier; CIRAD; National Academy of Sciences Ukraine; Institute of Ecology of Carpathians; Institut de Recherche pour le Developpement (IRD); CIRAD; Universite de Montpellier; CIRAD; Institut de Recherche pour le Developpement (IRD); Universite de Montpellier
  摘要：The emergence of infectious diseases, particularly those caused by fungal pathogens, poses serious threats to public health, wildlife and ecosystem stability1. Host-fungus interactions and environmental factors have been extensively examined2, 3-4. However, the role of genetic variability in pathogens is often less well-studied, even for diseases such as white-nose in bats, which has caused one of the highest disease-driven death tolls documented in nonhuman mammals5. Previous research on whit...
• Probing phonon transport dynamics across an interface by electron microscopy AI翻译
  作者：Liu, Fachen; Mao, Ruilin; Liu, Zhiqiang; Du, Jinlong; Gao, Peng
  作者单位：Peking University; Peking University; Peking University; Chinese Academy of Sciences; Peking University; Peking University; Tsinghua University; Collaborative Innovation Center of Quantum Matter
  摘要：Understanding thermal transport mechanisms across material interfaces is crucial for advancing semiconductor technologies, particularly in miniaturized devices operating under extreme power densities1,2. Although the interface phonon-mediated processes are theoretically established3, 4, 5-6 as the dominant mechanism for interfacial thermal transport in semiconductors7, their nanoscale dynamics remain experimentally elusive owing to challenges in measuring the temperature and non-equilibrium ph...
• Deep origin of eukaryotes outside Heimdallarchaeia within Asgardarchaeota AI翻译
  作者：Zhang, Jiawei; Feng, Xiaoyuan; Li, Meng; Liu, Yang; Liu, Min; Hou, Li-Jun; Dong, Hong-Po
  作者单位：East China Normal University; Shenzhen University; East China Normal University
  摘要：Research on the morphology, physiology and genomics of Asgard archaea has provided valuable insights into the evolutionary history of eukaryotes1, 2-3. A previous study suggested that eukaryotes are nested within Heimdallarchaeia4, but their exact phylogenetic placement within Asgard archaea remains controversial4,5. This debate complicates understanding of the metabolic features and timescales of early eukaryotic ancestors. Here we generated 223 metagenome-assembled nearly complete genomes of...
• Genomic and genetic insights into Mendel's pea genes AI翻译
  作者：Feng, Cong; Chen, Baizhi; Hofer, Julie; Shi, Yan; Jiang, Mei; Song, Bo; Cheng, Hong; Lu, Lu; Wang, Luyao; Howard, Alex; Bendahmane, Abdel; Fouchal, Anissa; Moreau, Carol; Sawada, Chie; LeSignor, Christine; Zhang, Cuijun; Vikeli, Eleni; Tsanakas, Georgios; Zhao, Hang; Cheema, Jitender; Barclay, J. Elaine; Hou, Junliang; Sayers, Liz; Wingen, Luzie; Vigouroux, Marielle; Vickers, Martin; Ambrose, Mike; Dalmais, Marion; Higuera-Poveda, Paola; Li, Pengfeng; Yuan, Quan; Spanner, Rebecca; Horler, Richard; Wouters, Roland; Chundakkad, Smitha; Wu, Tian; Zhao, Xiaoxiao; Li, Xiuli; Sun, Yuchen; Huang, Zejian; Wu, Zhen; Deng, Xing Wang; Steuernagel, Burkhard; Domoney, Claire; Ellis, Noel; Chayut, Noam; Cheng, Shifeng
  作者单位：Guangdong Laboratory for Lingnan Modern Agriculture; Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; INRAE; Universite Paris Saclay; Universite Paris Cite; INRAE; Universite Bourgogne Europe; INRAE; Institut Agro; AgroSup Dijon; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; University of Minnesota System; University of Minnesota Twin Cities; Peking University; Peking University
  摘要：Mendel1 studied in detail seven pairs of contrasting traits in pea (Pisum sativum), establishing the foundational principles of genetic inheritance. Here we investigate the genetic architecture that underlies these traits and uncover previously undescribed alleles for the four characterized Mendelian genes2, 3, 4, 5, 6-7, including a rare revertant of Mendel's white-flowered a allele. Primarily, we focus on the three remaining uncharacterized traits and find that (1) an approximately 100-kb ge...
• Chromosome end protection by RAP1-mediated inhibition of DNA-PK AI翻译
  作者：Eickhoff, Patrik; Sonmez, Ceylan; Fisher, Charlotte E. L.; Inian, Oviya; Roumeliotis, Theodoros I.; dello Stritto, Angela; Mansfeld, Jorg; Choudhary, Jyoti S.; Guettler, Sebastian; Lottersberger, Francisca; Douglas, Max E.
  作者单位：Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; Linkoping University; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust
  摘要：During classical non-homologous end joining (cNHEJ), DNA-dependent protein kinase (DNA-PK) encapsulates free DNA ends, forming a recruitment platform for downstream end-joining factors including ligase 4 (LIG4)1. DNA-PK can also bind telomeres and regulate their resection2, 3-4, but does not initiate cNHEJ at this position. How the end-joining process is regulated in this context-specific manner is currently unclear. Here we show that the shelterin components TRF2 and RAP1 form a complex with ...
• In the face of anti-science politics, silence is not without cost AI翻译
  作者：[Anonymous]
• Reprogramming site-specific retrotransposon activity to new DNA sites AI翻译
  作者：Fell, Christopher W.; Villiger, Lukas; Lim, Justin; Hiraizumi, Masahiro; Tagliaferri, Dario; Yarnall, Matthew T. N.; Lee, Anderson; Jiang, Kaiyi; Kayabolen, Alisan; Krajeski, Rohan N.; Schmitt-Ulms, Cian; Ramani, Harsh; Yousef, Sarah M.; Roberts, Nathaniel; Vakulskas, Christopher A.; Nishimasu, Hiroshi; Abudayyeh, Omar O.; Gootenberg, Jonathan S.
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Adventist Health Services; AdventHealth; Mass General Brigham; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; Massachusetts Institute of Technology (MIT); University of Tokyo; Integrated DNA Technologies IDT; University of Tokyo
  摘要：Retroelements have a critical role in shaping eukaryotic genomes. For instance, site-specific non-long terminal repeat retrotransposons have spread widely through preferential integration into repetitive genomic sequences, such as microsatellite regions and ribosomal DNA genes1, 2, 3, 4, 5-6. Despite the widespread occurrence of these systems, their targeting constraints remain unclear. Here we use a computational pipeline to discover multiple new site-specific retrotransposon families, profil...