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作者：Weij, Rieneke; Sniderman, J. M. Kale; Woodhead, Jon D.; Hellstrom, John C.; Brown, Josephine R.; Drysdale, Russell N.; Reed, Elizabeth; Bourne, Steven; Gordon, Jay
作者单位：University of Melbourne; Centre National de la Recherche Scientifique (CNRS); University of Adelaide; South Australian Museum; University of Cape Town; University of Cape Town
摘要：Late Pleistocene ice-age climates are routinely characterized as having imposed moisture stress on low- to mid-latitude ecosystems1-5. This idea is largely based on fossil pollen evidence for widespread, low-biomass glacial vegetation, interpreted as indicating climatic dryness6. However, woody plant growth is inhibited under low atmospheric CO2 (refs. 7,8), so understanding glacial environments requires the development of new palaeoclimate indicators that are independent of vegetation9. Here ...
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作者：Noble, Denis
作者单位：University of Oxford
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作者：Crossley, Magdalena P.; Song, Chenlin; Bocek, Michael J.; Choi, Jun-Hyuk; Kousouros, Joseph N.; Sathirachinda, Ataya; Lin, Cindy; Brickner, Joshua R.; Bai, Gongshi; Lans, Hannes; Vermeulen, Wim; Abu-Remaileh, Monther; Cimprich, Karlene A.
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作者：Osakada, Takuya; Yan, Rongzhen; Jiang, Yiwen; Wei, Dongyu; Tabuchi, Rina; Dai, Bing; Wang, Xiaohan; Zhao, Gavin; Wang, Clara Xi; Liu, Jing-Jing; Tsien, Richard W.; Mar, Adam C.; Lin, Dayu
作者单位：New York University; NYU Langone Medical Center; New York University; NYU Langone Medical Center; New York University; NYU Langone Medical Center
摘要：To survive in a complex social group, one needs to know who to approach and, more importantly, who to avoid. In mice, a single defeat causes the losing mouse to stay away from the winner for weeks1. Here through a series of functional manipulation and recording experiments, we identify oxytocin neurons in the retrochiasmatic supraoptic nucleus (SOROXT) and oxytocin-receptor-expressing cells in the anterior subdivision of the ventromedial hypothalamus, ventrolateral part (aVMHvlOXTR) as a key c...
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作者：Tang, Lina; Shao, Guofan; Groffman, Peter M.
作者单位：Chinese Academy of Sciences; Institute of Urban Environment, CAS; Purdue University System; Purdue University; City University of New York (CUNY) System
摘要：Letter to the Editor
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作者：Wirbel, Jakob; Bhatt, Ami S.; Probst, Alexander J.
作者单位：Stanford University; Stanford University
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作者：[Anonymous]
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作者：Torres, Susana Vazquez; Leung, Philip J. Y.; Venkatesh, Preetham; Lutz, Isaac D.; Hink, Fabian; Huynh, Huu-Hien; Becker, Jessica; Yeh, Andy Hsien-Wei; Juergens, David; Bennett, Nathaniel R.; Hoofnagle, Andrew N.; Huang, Eric; MacCoss, Michael J.; Exposit, Marc; Lee, Gyu Rie; Bera, Asim K.; Kang, Alex; De La Cruz, Joshmyn; Levine, Paul M.; Li, Xinting; Lamb, Mila; Gerben, Stacey R.; Murray, Analisa; Heine, Piper; Korkmaz, Elif Nihal; Nivala, Jeff; Stewart, Lance; Watson, Joseph L.; Rogers, Joseph M.; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Copenhagen; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
摘要：Many peptide hormones form an alpha-helix on binding their receptors1-4, and sensitive methods for their detection could contribute to better clinical management of disease5. De novo protein design can now generate binders with high affinity and specificity to structured proteins6,7. However, the design of interactions between proteins and short peptides with helical propensity is an unmet challenge. Here we describe parametric generation and deep learning-based methods for designing proteins ...
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作者：Jones, Nicola
摘要：Researchers are experimenting with different designs that could lower costs, extend vehicle ranges and offer other improvements.
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作者：Mylopotamitaki, Dorothea; Weiss, Marcel; Fewlass, Helen; Zavala, Elena Irene; Rougier, Helene; Suemer, Arev Pelin; Hajdinjak, Mateja; Smith, Geoff M.; Ruebens, Karen; Sinet-Mathiot, Virginie; Pederzani, Sarah; Essel, Elena; Harking, Florian S.; Xia, Huan; Hansen, Jakob; Kirchner, Andre; Lauer, Tobias; Stahlschmidt, Mareike; Hein, Michael; Talamo, Sahra; Wacker, Lukas; Meller, Harald; Dietl, Holger; Orschiedt, Joerg; Olsen, Jesper V.; Zeberg, Hugo; Pruefer, Kay; Krause, Johannes; Meyer, Matthias; Welker, Frido; Mcpherron, Shannon P.; Schueler, Tim; Hublin, Jean-Jacques
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; College de France; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Max Planck Society; University of Erlangen Nuremberg; Francis Crick Institute; University of California System; University of California Berkeley; California State University System; California State University Northridge; University of Kent; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite de Bordeaux; Universidad de la Laguna; University of Copenhagen; Lanzhou University; University of Copenhagen; Autonomous University of Barcelona; Eberhard Karls University of Tubingen; University of Vienna; Leuphana University Luneburg; Leipzig University; University of Bologna; Swiss Federal Institutes of Technology Domain; ETH Zurich; Karolinska Institutet
摘要：The Middle to Upper Palaeolithic transition in Europe is associated with the regional disappearance of Neanderthals and the spread of Homo sapiens. Late Neanderthals persisted in western Europe several millennia after the occurrence of H. sapiens in eastern Europe1. Local hybridization between the two groups occurred2, but not on all occasions3. Archaeological evidence also indicates the presence of several technocomplexes during this transition, complicating our understanding and the associat...
