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作者：Huang, Guanhao; Beccari, Alberto; Engelsen, Nils J.; Kippenberg, Tobias J.
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Chalmers University of Technology
摘要：At room temperature, mechanical motion driven by the quantum backaction of light has been observed only in pioneering experiments in which an optical restoring force controls the oscillator stiffness1,2. For solid-state mechanical resonators in which oscillations are controlled by the material rigidity, the observation of these effects has been hindered by low mechanical quality factors, optical cavity frequency fluctuations3, thermal intermodulation noise4,5 and photothermal instabilities. He...
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作者：[Anonymous]
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作者：Plume, Andrew
作者单位：Reed Elsevier; Elsevier
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作者：Ali, Saleem H.
作者单位：University of Delaware
摘要：Letter to the Editor
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作者：Dolgin, Elie
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作者：Pountain, Andrew W.; Jiang, Peien; Yao, Tianyou; Homaee, Ehsan; Guan, Yichao; McDonald, Kevin J. C.; Podkowik, Magdalena; Shopsin, Bo; Torres, Victor J.; Golding, Ido; Yanai, Itai
作者单位：New York University; New York University; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; New York University; New York University; St Jude Children's Research Hospital; University of Illinois System; University of Illinois Urbana-Champaign; New York University
摘要：Organisms determine the transcription rates of thousands of genes through a few modes of regulation that recur across the genome(1). In bacteria, the relationship between the regulatory architecture of a gene and its expression is well understood for individual model gene circuits(2,3). However, a broader perspective of these dynamics at the genome scale is lacking, in part because bacterial transcriptomics has hitherto captured only a static snapshot of expression averaged across millions of ...
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作者：Goodge, Berit H.
作者单位：Max Planck Society
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作者：Garcia, Julie; Daniels, Jay; Lee, Yujin; Zhu, Iowis; Cheng, Kathleen; Liu, Qing; Goodman, Daniel; Burnett, Cassandra; Law, Calvin; Thienpont, Chloe; Alavi, Josef; Azimi, Camillia; Montgomery, Garrett; Roybal, Kole T.; Choi, Jaehyuk
作者单位：University of California System; University of California San Francisco; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco; Northwestern University; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Robert H. Lurie Comprehensive Cancer Center; Ann & Robert H. Lurie Children's Hospital of Chicago
摘要：Adoptive T cell therapies have produced exceptional responses in a subset of patients with cancer. However, therapeutic efficacy can be hindered by poor T cell persistence and function1. In human T cell cancers, evolution of the disease positively selects for mutations that improve fitness of T cells in challenging situations analogous to those faced by therapeutic T cells. Therefore, we reasoned that these mutations could be co-opted to improve T cell therapies. Here we systematically screene...
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作者：Marris, Emma
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作者：Boubenec, Yves
作者单位：Universite PSL; Ecole Normale Superieure (ENS)
摘要：A neural probe has been used to capture the activity of large populations of single neurons as people are speaking or listening, providing detailed insights into how the brain encodes specific features of speech.
