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作者：Stirling, Andy
作者单位：University of Sussex
摘要：Personal priorities are often trumping real needs and skewing where charitable funding goes.
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作者：Murayama, Yasuto; Endo, Shizuko; Kurokawa, Yumiko; Kurita, Ayako; Iwasaki, Sanae; Araki, Hiroyuki
作者单位：Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; Japan Science & Technology Agency (JST); Research Organization of Information & Systems (ROIS)
摘要：Two newly duplicated copies of genomic DNA are held together by the ring-shaped cohesin complex to ensure faithful inheritance of the genome during cell division(1-3). Cohesin mediates sister chromatid cohesion by topologically entrapping two sister DNAs during DNA replication(4,5), but how cohesion is established at the replication fork is poorly understood. Here, we studied the interplay between cohesin and replication by reconstituting a functional replisome using purified proteins. Once DN...
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作者：Bond, Alexander L.; Kelly, Tyler L.
作者单位：Natural History Museum London; University of Birmingham
摘要：Letter to the Editor
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作者：Chen, Xing-Yan; Biswas, Shrestha; Eppelt, Sebastian; Schindewolf, Andreas; Deng, Fulin; Shi, Tao; Yi, Su; Hilker, Timon A.; Bloch, Immanuel; Luo, Xin-Yu
作者单位：Max Planck Society; Wuhan University; Chinese Academy of Sciences; Institute of Theoretical Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Beihang University; University of Munich
摘要：Ultracold polyatomic molecules offer opportunities1 in cold chemistry2,3, precision measurements4 and quantum information processing5,6, because of their rich internal structure. However, their increased complexity compared with diatomic molecules presents a challenge in using conventional cooling techniques. Here we demonstrate an approach to create weakly bound ultracold polyatomic molecules by electroassociation7 (F.D. et al., manuscript in preparation) in a degenerate Fermi gas of microwav...
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作者：Murphy, Michael P.; O'Neill, Luke A. J.
作者单位：University of Cambridge; University of Cambridge; Trinity College Dublin
摘要：Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not recognize them as foreign because the organelles are sequestered. However, the regulated release of mitochondrial factors into the cytosol can trigger cell death, innate immunity and inflammation. This selective breakdown in the 2-billion-year-old endosymbiotic relationship enables mitochondria to act as intracellular signalling hubs. Mitochondrial signals include proteins, nucleic acids, phospholipid...
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作者：Okubo, Takumi; Rivron, Nicolas; Kabata, Mio; Masaki, Hideki; Kishimoto, Keiko; Semi, Katsunori; Nakajima-Koyama, May; Kunitomi, Haruko; Kaswandy, Belinda; Sato, Hideyuki; Nakauchi, Hiromitsu; Woltjen, Knut; Saitou, Mitinori; Sasaki, Erika; Yamamoto, Takuya; Takashima, Yasuhiro
作者单位：Kyoto University; Austrian Academy of Sciences; Vienna Biocenter (VBC); Institute of Molecular Biotechnology (IMBA); University of Tokyo; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Stanford University; Kyoto University; Kyoto University; RIKEN
摘要：Recently, several studies using cultures of human embryos together with single-cell RNA-seq analyses have revealed differences between humans and mice, necessitating the study of human embryos1-8. Despite the importance of human embryology, ethical and legal restrictions have limited post-implantation-stage studies. Thus, recent efforts have focused on developing in vitro self-organizing models using human stem cells9-17. Here, we report genetic and non-genetic approaches to generate authentic...
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作者：McMahan, Katherine; Wegmann, Frank; Aid, Malika; Sciacca, Michaela; Liu, Jinyan; Hachmann, Nicole P.; Miller, Jessica; Jacob-Dolan, Catherine; Powers, Olivia; Hope, David; Wu, Cindy; Pereira, Juliana; Murdza, Tetyana; Mazurek, Camille R.; Hoyt, Amelia; Boon, Adrianus C. M.; Davis-Gardner, Meredith; Suthar, Mehul S.; Martinot, Amanda J.; Boursiquot, Mona; Cook, Anthony; Pessaint, Laurent; Lewis, Mark G.; Andersen, Hanne; Tolboom, Jeroen; Serroyen, Jan; Solforosi, Laura; Costes, Lea M. M.; Zahn, Roland C.; Barouch, Dan H.
作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Ragon Institute; Washington University (WUSTL); Emory University; Tufts University; BIOQUAL Inc.
摘要：A limitation of current SARS-CoV-2 vaccines is that they provide minimal protection against infection with current Omicron subvariants1,2, although they still provide protection against severe disease. Enhanced mucosal immunity may be required to block infection and onward transmission. Intranasal administration of current vaccines has proven inconsistent3-7, suggesting that alternative immunization strategies may be required. Here we show that intratracheal boosting with a bivalent Ad26-based...
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作者：Tibbs, Taylor
作者单位：University of North Carolina; University of North Carolina Chapel Hill
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作者：Tollefson, Jeff
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作者：Zhang, Ketao; Chermprayong, Pisak; Xiao, Feng; Tzoumanikas, Dimos; Dams, Barrie; Kay, Sebastian; Kocer, Basaran Bahadir; Burns, Alec; Orr, Lachlan; Alhinai, Talib; Choi, Christopher; Darekar, Durgesh Dattatray; Li, Wenbin; Hirschmann, Steven; Soana, Valentina; Ngah, Shamsiah Awang; Grillot, Clement; Sareh, Sina; Choubey, Ashutosh; Margheri, Laura; Pawar, Vijay M.; Ball, Richard J.; Williams, Chris; Shepherd, Paul; Leutenegger, Stefan; Stuart-Smith, Robert; Kovac, Mirko
作者单位：Imperial College London; University of London; Queen Mary University London; Imperial College London; University of Bath; University of London; University College London; Technical University of Munich; University of Pennsylvania; Swiss Federal Institutes of Technology Domain; Swiss Federal Laboratories for Materials Science & Technology (EMPA)
