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作者:Tye, Simon P.; Fey, Samuel B.; Gibert, Jean P.; Siepielski, Adam M.
作者单位:University of Arkansas System; University of Arkansas Fayetteville; Reed College - Portland; Duke University
摘要:Predators have a key role in structuring ecosystems1-4. However, predator loss is accelerating globally4-6, and predator mass-mortality events7 (MMEs)-rapid large-scale die-offs-are now emblematic of the Anthropocene epoch6. Owing to their rare and unpredictable nature7, we lack an understanding of how MMEs immediately impact ecosystems. Past predator-removal studies2,3 may be insufficient to understand the ecological consequences of MMEs because, in nature, dead predators decompose in situ an...
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作者:Woodruff, Kelsey Alexandra; Termini, Christina Marie
作者单位:University of Washington; University of Washington Seattle
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作者:Cuk, Matija; Rhoden, Alyssa Rose
作者单位:SETI Institute; Southwest Research Institute
摘要:The shifting orbit of one of Saturn's moons indicates that the satellite has a subsurface ocean, contradicting theories that its interior is entirely solid. The finding calls for a fresh take on what constitutes an ocean moon.
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作者:Freitas, Florencio Porto; Alborzinia, Hamed; dos Santos, Ancely Ferreira; Nepachalovich, Palina; Pedrera, Lohans; Zilka, Omkar; Inague, Alex; Klein, Corinna; Aroua, Nesrine; Kaushal, Kamini; Kast, Bettina; Lorenz, Svenja M.; Kunz, Viktoria; Nehring, Helene; da Silva, Thamara N. Xavier; Chen, Zhiyi; Atici, Sena; Doll, Sebastian G.; Schaefer, Emily L.; Ekpo, Ifedapo; Schmitz, Werner; Horling, Aline; Imming, Peter; Miyamoto, Sayuri; Wehman, Ann M.; Genaro-Mattos, Thiago C.; Mirnics, Karoly; Kumar, Lokender; Klein-Seetharaman, Judith; Meierjohann, Svenja; Weigand, Isabel; Kroiss, Matthias; Bornkamm, Georg W.; Gomes, Fernando; Netto, Luis Eduardo Soares; Sathian, Manjima B.; Konrad, David B.; Covey, Douglas F.; Michalke, Bernhard; Bommert, Kurt; Bargou, Ralf C.; Garcia-Saez, Ana; Pratt, Derek A.; Fedorova, Maria; Trumpp, Andreas; Conrad, Marcus; Angeli, Jose Pedro Friedmann
作者单位:University of Wurzburg; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Technische Universitat Dresden; Carl Gustav Carus University Hospital; Technische Universitat Dresden; University of Cologne; University of Ottawa; Universidade de Sao Paulo; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Wurzburg; University of Wurzburg; Martin Luther University Halle Wittenberg; University of Denver; University of Nebraska System; University of Nebraska Medical Center; Shoolini University; Colorado School of Mines; Arizona State University; Arizona State University-Downtown Phoenix; University of Wurzburg; University of Munich; Ulm University; Universidade de Sao Paulo; University of Munich; Washington University (WUSTL); Washington University (WUSTL); Helmholtz Association; German Cancer Research Center (DKFZ)
摘要:Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation that tumours exploit to counteract phospholipid oxidation1,2. Here, we identify proferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected prosurvival function of its substrate, 7-dehydrocholesterol (7-DHC). Although previous studies suggested that high concen...
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作者:King, Jean
作者单位:Worcester Polytechnic Institute
摘要:Under-represented groups face chronic barriers, creating psychological - and physical - effects. The scientific community must ease this burden.
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作者:Li, Xi; Wang, Shuai; Luo, Xiang; Zhou, Yu-Yang; Xie, Ke; Shen, Hong-Chi; Nie, Yu-Zhao; Chen, Qijin; Hu, Hui; Chen, Yu-Ao; Yao, Xing-Can; Pan, Jian-Wei
作者单位:Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Hefei National Laboratory; Swinburne University of Technology
摘要:The microscopic origin of high-temperature superconductivity in cuprates remains unknown. It is widely believed that substantial progress could be achieved by better understanding of the pseudogap phase, a normal non-superconducting state of cuprates1,2. In particular, a central issue is whether the pseudogap could originate from strong pairing fluctuations3. Unitary Fermi gases4,5, in which the pseudogap-if it exists-necessarily arises from many-body pairing, offer ideal quantum simulators to...
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作者:Zhang, Donna D.
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作者:Gentry, Emily C.; Collins, Stephanie L.; Panitchpakdi, Morgan; Belda-Ferre, Pedro; Stewart, Allison K.; Terrazas, Marvic Carrillo; Lu, Hsueh-han; Zuffa, Simone; Yan, Tingting; Avila-Pacheco, Julian; Plichta, Damian R.; Aron, Allegra T.; Wang, Mingxun; Jarmusch, Alan K.; Hao, Fuhua; Syrkin-Nikolau, Mashette; Vlamakis, Hera; Ananthakrishnan, Ashwin N.; Boland, Brigid S.; Hemperly, Amy; Vande Casteele, Niels; Gonzalez, Frank J.; Clish, Clary B.; Xavier, Ramnik J.; Chu, Hiutung; Baker, Erin S.; Patterson, Andrew D.; Knight, Rob; Siegel, Dionicio; Dorrestein, Pieter C.
作者单位:University of California System; University of California San Diego; University of California System; University of California San Diego; Virginia Polytechnic Institute & State University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California San Diego; University of California System; University of California San Diego; North Carolina State University; University of California System; University of California San Diego; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California San Diego; Rady Childrens Hospital San Diego; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of California System; University of California San Diego; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of California System; University of California San Diego; University of North Carolina; University of North Carolina Chapel Hill; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要:Determining the structure and phenotypic context of molecules detected in untargeted metabolomics experiments remains challenging. Here we present reverse metabolomics as a discovery strategy, whereby tandem mass spectrometry spectra acquired from newly synthesized compounds are searched for in public metabolomics datasets to uncover phenotypic associations. To demonstrate the concept, we broadly synthesized and explored multiple classes of metabolites in humans, including N-acyl amides, fatty...
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作者:Kuibarov, Andrii; Suvorov, Oleksandr; Vocaturo, Riccardo; Fedorov, Alexander; Lou, Rui; Merkwitz, Luise; Voroshnin, Vladimir; Facio, Jorge I.; Koepernik, Klaus; Yaresko, Alexander; Shipunov, Grigory; Aswartham, Saicharan; van den Brink, Jeroen; Buechner, Bernd; Borisenko, Sergey
作者单位:Leibniz Association; Leibniz Institute for Solid State & Materials Research Dresden; Institute for Integrative Nanosciences (IIN); National Academy of Sciences Ukraine; Kyiv Academic University; Helmholtz Association; Helmholtz-Zentrum fuer Materialien und Energie GmbH (HZB); Max Planck Society; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR)
摘要:An essential ingredient for the production of Majorana fermions for use in quantum computing is topological superconductivity1,2. As bulk topological superconductors remain elusive, the most promising approaches exploit proximity-induced superconductivity3, making systems fragile and difficult to realize4-7. Due to their intrinsic topology8, Weyl semimetals are also potential candidates1,2, but have always been connected with bulk superconductivity, leaving the possibility of intrinsic superco...
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作者:Magrach, Ainhoa
作者单位:Basque Centre for Climate Change (BC3)
摘要:Letter to the Editor