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作者：Li, Siyu; Harir, Mourad; Bastviken, David; Schmitt-Kopplin, Philippe; Gonsior, Michael; Enrich-Prast, Alex; Valle, Juliana; Hertkorn, Norbert
作者单位：Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Linkoping University; University System of Maryland; University of Maryland Center for Environmental Science; Universidade Federal de Sao Paulo (UNIFESP)
摘要：Dissolved organic matter (DOM) is one of the most complex, dynamic and abundant sources of organic carbon, but its chemical reactivity remains uncertain 1-3 . Greater insights into DOM structural features could facilitate understanding its synthesis, turnover and processing in the global carbon cycle 4,5 . Here we use complementary multiplicity-edited 13C nuclear magnetic resonance (NMR) spectra to quantify key substructures assembling the carbon skeletons of DOM from four main Amazon rivers a...
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作者：[Anonymous]
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作者：[Anonymous]
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作者：Djellouli, Adel; Van Raemdonck, Bert; Wang, Yang; Yang, Yi; Caillaud, Anthony; Weitz, David; Rubinstein, Shmuel; Gorissen, Benjamin; Bertoldi, Katia
作者单位：Harvard University; KU Leuven; Hebrew University of Jerusalem
摘要：The pursuit of materials with enhanced functionality has led to the emergence of metamaterials-artificially engineered materials whose properties are determined by their structure rather than composition. Traditionally, the building blocks of metamaterials are arranged in fixed positions within a lattice structure(1-19). However, recent research has revealed the potential of mixing disconnected building blocks in a fluidic medium(20-27). Inspired by these recent advances, here we show that by ...
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作者：Mao, Fangyuan; Zhang, Chi; Ren, Jicheng; Wang, Tao; Wang, Guofu; Zhang, Fakui; Rich, Thomas; Vickers-Rich, Patricia; Meng, Jin
作者单位：Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; American Museum of Natural History (AMNH); Monash University; Curtin University; City University of New York (CUNY) System
摘要：The dual jaw joint of Morganucodon(1,2) consists of the dentary-squamosal joint laterally and the articular-quadrate one medially. The articular-quadrate joint and its associated post-dentary bones constitute the precursor of the mammalian middle ear. Fossils documenting the transition from such a precursor to the mammalian middle ear are poor, resulting in inconsistent interpretations of this hallmark apparatus in the earliest stage of mammaliaform evolution(1-5). Here we report mandibular mi...
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作者：[Anonymous]
摘要：Paring down the astronomical complexity of the protein-folding problem, plus Isaac Newton's ambiguous use of the word 'axiom', in the weekly dip into Nature's archive.
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作者：Johnson, Alex G.; Mayer, Megan L.; Schaefer, Stefan L.; McNamara-Bordewick, Nora K.; Hummer, Gerhard; Kranzusch, Philip J.
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Max Planck Society; Goethe University Frankfurt; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要：In response to pathogen infection, gasdermin (GSDM) proteins form membrane pores that induce a host cell death process called pyroptosis(1-3). Studies of human and mouse GSDM pores have revealed the functions and architectures of assemblies comprising 24 to 33 protomers(4-9), but the mechanism and evolutionary origin of membrane targeting and GSDM pore formation remain unknown. Here we determine a structure of a bacterial GSDM (bGSDM) pore and define a conserved mechanism of pore assembly. Eng...
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作者：Prillaman, McKenzie
摘要：Many researchers think that Wegovy and Ozempic should be taken for life, but myriad factors can force people off them.
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作者：Farrell, Jordan S.; Hwaun, Ernie; Dudok, Barna; Soltesz, Ivan
作者单位：Stanford University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Baylor College of Medicine
摘要：Distinct brain and behavioural states are associated with organized neural population dynamics that are thought to serve specific cognitive functions(1, 2-3). Memory replay events, for example, occur during synchronous population events called sharp-wave ripples in the hippocampus while mice are in an 'offline' behavioural state, enabling cognitive mechanisms such as memory consolidation and planning(4, 5, 6, 7, 8, 9, 10-11). But how does the brain re-engage with the external world during this...
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作者：Reardon, Sara
摘要：The bioengineered immune players called CAR T cells last longer and work better if pumped up with a large dose of a protein that makes them resemble stem cells.
