Transcranial volumetric imaging using a conformal ultrasound patch

• 成果类型: Article
• 署名作者: Zhou, Sai; Gao, Xiaoxiang; Park, Geonho; Yang, Xinyi; Qi, Baiyan; Lin, Muyang; Huang, Hao; Bian, Yizhou; Hu, Hongjie; Chen, Xiangjun; Wu, Ray S.; Liu, Boyu; Yue, Wentong; Lu, Chengchangfeng; Wang, Ruotao; Bheemreddy, Pranavi; Qin, Siyu; Lam, Arthur; Wear, Keith A.; Andre, Michael; Kistler, Erik B.; Newell, David W.; Xu, Sheng
• 署名单位: University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; US Food & Drug Administration (FDA); University of California System; University of California San Diego; University of California System; University of California San Diego
• 刊物名称: Nature
• ISSN/ISSBN: 0028-5360
• DOI: 10.1038/s41586-024-07381-5
• 发表日期: 2024-05-23
• 页码: 810-+
• 关键词: cerebral-blood-flow; electrical-impedance tomography; temporal bone window; doppler ultrasound; acoustic window; brain helmet; population; thickness; adults; ct

摘要

Accurate and continuous monitoring of cerebral blood flow is valuable for clinical neurocritical care and fundamental neurovascular research. Transcranial Doppler (TCD) ultrasonography is a widely used non-invasive method for evaluating cerebral blood flow(1), but the conventional rigid design severely limits the measurement accuracy of the complex three-dimensional (3D) vascular networks and the practicality for prolonged recording(2). Here we report a conformal ultrasound patch for hands-free volumetric imaging and continuous monitoring of cerebral blood flow. The 2MHz ultrasound waves reduce the attenuation and phase aberration caused by the skull, and the copper mesh shielding layer provides conformal contact to the skin while improving the signal-to-noise ratio by 5dB. Ultrafast ultrasound imaging based on diverging waves can accurately render the circle of Willis in 3D and minimize human errors during examinations. Focused ultrasound waves allow the recording of blood flow spectra at selected locations continuously. The high accuracy of the conformal ultrasound patch was confirmed in comparison with a conventional TCD probe on 36 participants, showing a mean difference and standard deviation of difference as -1.514.34cms(-1), -0.84 +/- 3.06cms(-1) and -0.50 +/- 2.55cms(-1) for peak systolic velocity, mean flow velocity, and end diastolic velocity, respectively. The measurement success rate was 70.6%, compared with 75.3% for a conventional TCD probe. Furthermore, we demonstrate continuous blood flow spectra during different interventions and identify cascades of intracranial B waves during drowsiness within 4h of recording.