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• High-resolution in situ structures of mammalian respiratory supercomplexes AI翻译
  作者：Zheng, Wan; Chai, Pengxin; Zhu, Jiapeng; Zhang, Kai
  作者单位：Nanjing University of Chinese Medicine; Yale University
  摘要：Mitochondria play a pivotal part in ATP energy production through oxidative phosphorylation, which occurs within the inner membrane through a series of respiratory complexes(1-4). Despite extensive in vitro structural studies, determining the atomic details of their molecular mechanisms in physiological states remains a major challenge, primarily because of loss of the native environment during purification. Here we directly image porcine mitochondria using an in situ cryo-electron microscopy ...
• Expanding chemistry through in vitro and in vivo biocatalysis AI翻译
  作者：Kissman, Elijah N.; Sosa, Max B.; Millar, Douglas C.; Koleski, Edward J.; Thevasundaram, Kershanthen; Chang, Michelle C. Y.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Princeton University
  摘要：Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes and cells as potential biocatalysts for chemical processes. The properties of protein and cell biocatalysts-high selectivity, the ability to control reaction sequence and operation in environmentally benign conditions-offer approaches to produce molecules at high efficiency while lowering the cost and environmental impact of industrial chemistry. Furthermore, biocatalysis offers the opportunity to gener...
• GETTING UNDER THE SKIN OF ROBOTS TO MAKE THEM SMILE AI翻译
  作者：[Anonymous]
• Structural basis for pegRNA-guided reverse transcription by a prime editor AI翻译
  作者：Shuto, Yutaro; Nakagawa, Ryoya; Zhu, Shiyou; Hoki, Mizuki; Omura, Satoshi N.; Hirano, Hisato; Itoh, Yuzuru; Zhang, Feng; Nureki, Osamu
  作者单位：University of Tokyo; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute
  摘要：The prime editor system composed of Streptococcus pyogenes Cas9 nickase (nSpCas9) and engineered Moloney murine leukaemia virus reverse transcriptase (M-MLV RT) collaborates with a prime editing guide RNA (pegRNA) to facilitate a wide variety of precise genome edits in living cells(1). However, owing to a lack of structural information, the molecular mechanism of pegRNA-guided reverse transcription by the prime editor remains poorly understood. Here we present cryo-electron microscopy structur...
• Streamlined collaboration can boost CRISPR gene therapies for rare diseases AI翻译
  作者：He, Wei; Zeng, Shuxiong; Xu, Chuanliang
  作者单位：Naval Medical University; Shanghai Jiao Tong University
• UK general election: five reasons it matters for science AI翻译
  作者：O'Callaghan, Jonathan; Gibney, Elizabeth
• Twelve scientist-endorsed tips to get over writer's block AI翻译
  作者：Sohn, Emily
  摘要：How do you get your creative juices flowing after spending hours, days or months looking at a blank screen? Researchers share their advice.
• Megastudy shows that reminders boost vaccination but adding free rides does not AI翻译
  作者：Milkman, Katherine L.; Ellis, Sean F.; Gromet, Dena M.; Jung, Youngwoo; Luscher, Alex S.; Mobarak, Rayyan S.; Paxson, Madeline K.; Zumaran, Ramon A. Silvera; Kuan, Robert; Berman, Ron; Lewis Jr, Neil A.; List, John A.; Patel, Mitesh S.; Van den Bulte, Christophe; Volpp, Kevin G.; Beauvais, Maryann V.; Bellows, Jonathon K.; Marandola, Cheryl A.; Duckworth, Angela L.
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University System of Maryland; University of Maryland College Park; University of Pennsylvania; Cornell University; University of Chicago; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
  摘要：Encouraging routine COVID-19 vaccinations is likely to be a crucial policy challenge for decades to come. To avert hundreds of thousands of unnecessary hospitalizations and deaths, adoption will need to be higher than it was in the autumn of 2022 or 2023, when less than one-fifth of Americans received booster vaccines1,2. One approach to encouraging vaccination is to eliminate the friction of transportation hurdles. Previous research has shown that friction can hinder follow-through3 and that ...
• Last year's summer was the warmest in 2,000 years AI翻译
  作者：Hegerl, Gabriele C.; Taylor, Katherine L.
  作者单位：University of Edinburgh
  摘要：A record spanning two millennia of Northern Hemisphere summer temperatures has revealed the extent to which 2023 was anomalously hot. The finding is a striking confirmation of warming since the pre-industrial period
• Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair AI翻译
  作者：Mehrotra, Parul; Maschalidi, Sophia; Boeckaerts, Laura; Maueroder, Christian; Tixeira, Rochelle; Pinney, Jonathan; Cardas, Javier Burgoa; Sukhov, Vladimir; Incik, Yunus; Anderson, Christopher. J.; Hu, Bing; Keceli, Burcu N.; Goncalves, Amanda; Vande Walle, Lieselotte; Van Opdenbosch, Nina; Sergushichev, Alexey; Hoste, Esther; Jain, Umang; Lamkanfi, Mohamed; Ravichandran, Kodi S.
  作者单位：Ghent University; Flanders Institute for Biotechnology (VIB); Ghent University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Delhi; University of Virginia; ITMO University; Washington University (WUSTL); Flanders Institute for Biotechnology (VIB); Ghent University; Washington University (WUSTL)
  摘要：Pyroptosis is a lytic cell death mode that helps limit the spread of infections and is also linked to pathology in sterile inflammatory diseases and autoimmune diseases1-4. During pyroptosis, inflammasome activation and the engagement of caspase-1 lead to cell death, along with the maturation and secretion of the inflammatory cytokine interleukin-1 beta (IL-1 beta). The dominant effect of IL-1 beta in promoting tissue inflammation has clouded the potential influence of other factors released f...