Nature

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• LAB-GROWN EMBRYO MODELS: UK UNVEILS FIRST EVER RULES TO GUIDE RESEARCH AI翻译
  作者：Mallapaty, Smriti
• Fabrication of red-emitting perovskite LEDs by stabilizing their octahedral structure (vol 631, pg 73, 2024) AI翻译
  作者：Kong, Lingmei; Sun, Yuqi; Zhao, Bin; Ji, Kangyu; Feng, Jie; Dong, Jianchao; Wang, Yuanzhi; Liu, Zirui; Maqbool, Shabnum; Li, Yunguo; Yang, Yingguo; Dai, Linjie; Lee, Wanhee; Cho, Changsoon; Stranks, Samuel D.; Friend, Richard H.; Wang, Ning; Greenham, Neil C.; Yang, Xuyong
• CHEMISTRY'S SALTY HEADACHE AI翻译
  作者：Lim, Xiaozhi
• TnpB homologues exapted from transposons are RNA-guided transcription factors AI翻译
  作者：Wiegand, Tanner; Hoffmann, Florian T.; Walker, Matt W. G.; Tang, Stephen; Richard, Egill; Le, Hoang C.; Meers, Chance; Sternberg, Samuel H.
  作者单位：Columbia University; Columbia University
  摘要：Transposon-encoded tnpB and iscB genes encode RNA-guided DNA nucleases that promote their own selfish spread through targeted DNA cleavage and homologous recombination(1-4). These widespread gene families were repeatedly domesticated over evolutionary timescales, leading to the emergence of diverse CRISPR-associated nucleases including Cas9 and Cas12 (refs. (5,6)). We set out to test the hypothesis that TnpB nucleases may have also been repurposed for novel, unexpected functions other than CRI...
• Alzheimer's plaques and tangles revealed by 3D microscopy AI翻译
  作者：Scheres, Sjors H. W.
  作者单位：MRC Laboratory Molecular Biology
  摘要：Amyloid-beta peptides and tau proteins form filaments in the brain in Alzheimer's disease. Using an electron microscopy approach to visualize thin slices of brain tissue in 3D, these filaments can be seen in their native environment.
• 3D model brains with cells from several people are first of their kind AI翻译
  作者：Mullard, Asher
• Atom-swap chemistry speeds synthesis of compounds for drug discovery AI翻译
  作者：Renteria-Gomez, Angel; Gutierrez, Osvaldo
  作者单位：Texas A&M University System; Texas A&M University College Station
• Research priorities for the next government AI翻译
  作者：[Anonymous]
  摘要：Ministers must take a global view of science, address a growing crisis in university finances and put a stop to interference in research autonomy.
• An alternative broad-specificity pathway for glycan breakdown in bacteria AI翻译
  作者：Nasseri, Seyed Amirhossein; Lazarski, Aleksander C.; Lemmer, Imke L.; Zhang, Chloe Y.; Brencher, Eva; Chen, Hong-Ming; Sim, Lyann; Panwar, Deepesh; Betschart, Leo; Worrall, Liam J.; Brumer, Harry; Strynadka, Natalie C. J.; Withers, Stephen G.
  作者单位：University of British Columbia; University of British Columbia; University of British Columbia; University of British Columbia
  摘要：The vast majority of glycosidases characterized to date follow one of the variations of the 'Koshland' mechanisms(1) to hydrolyse glycosidic bonds through substitution reactions. Here we describe a large-scale screen of a human gut microbiome metagenomic library using an assay that selectively identifies non-Koshland glycosidase activities(2). Using this, we identify a cluster of enzymes with extremely broad substrate specificities and thoroughly characterize these, mechanistically and structu...
• Most nearby young star clusters formed in three massive complexes AI翻译
  作者：Swiggum, Cameren; Alves, Joao; Benjamin, Robert; Ratzenboeck, Sebastian; Miret-Roig, Nuria; Grossschedl, Josefa; Meingast, Stefan; Goodman, Alyssa; Konietzka, Ralf; Zucker, Catherine; Hunt, Emily L.; Reffert, Sabine
  作者单位：University of Vienna; University of Wisconsin System; University of Vienna; University of Cologne; Smithsonian Institution; Ruprecht Karls University Heidelberg
  摘要：Efforts to unveil the structure of the local interstellar medium and its recent star-formation history have spanned the past 70 years (refs. 1-6). Recent studies using precise data from space astrometry missions have revealed nearby, newly formed star clusters with connected origins7-12. Nonetheless, mapping young clusters across the entire sky back to their natal regions has been hindered by a lack of clusters with precise radial-velocity data. Here we show that 155 out of 272 (57%) high-qual...