Nature

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• Why cancer risk declines sharply in old age AI翻译
  作者：Ledford, Heidi
  摘要：New research identifies some of the genes that could help to explain why lung cancer incidence rises with age but declines after the age of 75.
• Kinetic features dictate sensorimotor alignment in the superior colliculus AI翻译
  作者：Gonzalez-Rueda, Ana; Jensen, Kristopher; Noormandipour, Mohammadreza; de Malmazet, Daniel; Wilson, Jonathan; Ciabatti, Ernesto; Kim, Jisoo; Williams, Elena; Poort, Jasper; Hennequin, Guillaume; Tripodi, Marco
  作者单位：MRC Laboratory Molecular Biology; University of Cambridge; University of Cambridge; University of Cambridge; Nokia Corporation; Nokia United Kingdom; University of Cambridge
  摘要：The execution of goal-oriented behaviours requires a spatially coherent alignment between sensory and motor maps. The current model for sensorimotor transformation in the superior colliculus relies on the topographic mapping of static spatial receptive fields onto movement endpoints(1-6). Here, to experimentally assess the validity of this canonical static model of alignment, we dissected the visuo-motor network in the superior colliculus and performed in vivo intracellular and extracellular r...
• SUBSTITUTE STONE AGE? ANCIENT AMBER BEADS ARE FAKES AI翻译
  作者：[Anonymous]
• TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A (vol 603, pg 131, 2022) AI翻译
  作者：Brown, Anna-Leigh; Wilkins, Oscar G.; Keuss, Matthew J.; Hill, Sarah E.; Zanovello, Matteo; Lee, Weaverly Colleen; Bampton, Alexander; Lee, Flora C. Y.; Masino, Laura; Qi, Yue A.; Bryce-Smith, Sam; Gatt, Ariana; Hallegger, Martina; Fagegaltier, Delphine; Phatnani, Hemali; Phatnani, Hemali; Newcombe, Jia; Gustavsson, Emil K.; Seddighi, Sahba; Reyes, Joel F.; Coon, Steven L.; Ramos, Daniel; Schiavo, Giampietro; Fisher, Elizabeth M. C.; Raj, Towfique; Secrier, Maria; Lashley, Tammaryn; Ule, Jernej; Buratti, Emanuele; Humphrey, Jack; Ward, Michael E.; Fratta, Pietro
• Enzyme blueprints will aid tuberculosis drug design AI翻译
  作者：Cook, Gregory M.; McNeil, Matthew B.
  作者单位：University of Queensland; Queensland University of Technology (QUT); University of Otago
• Harrowing trends: how endangered-species researchers find hope in the dark AI翻译
  作者：Forrester, Nikki
  摘要：When data collection can be damaging, conservation scientists must balance ethical trade-offs between interference and inaction.
• How Canada boosted PhD and postdoc pay AI翻译
  作者：Kharas, Kaitlin
  作者单位：University of Toronto
• The economic commitment of climate change (vol 628, pg 551, 2024) AI翻译
  作者：Kotz, Maximilian; Levermann, Anders; Wenz, Leonie
• Ultra-detailed brain map shows neurons that encode words' meaning AI翻译
  作者：Reardon, Sara
  摘要：For the first time, scientists identify individual brain cells linked to the linguistic essence of a word.
• Connectomic reconstruction of a female Drosophila ventral nerve cord AI翻译
  作者：Azevedo, Anthony; Lesser, Ellen; Phelps, Jasper S.; Mark, Brandon; Elabbady, Leila; Kuroda, Sumiya; Sustar, Anne; Moussa, Anthony; Khandelwal, Avinash; Dallmann, Chris J.; Agrawal, Sweta; Lee, Su-Yee J.; Pratt, Brandon; Cook, Andrew; Skutt-Kakaria, Kyobi; Gerhard, Stephan; Lu, Ran; Kemnitz, Nico; Lee, Kisuk; Halageri, Akhilesh; Castro, Manuel; Ih, Dodam; Gager, Jay; Tammam, Marwan; Dorkenwald, Sven; Collman, Forrest; Schneider-Mizell, Casey; Brittain, Derrick; Jordan, Chris S.; Dickinson, Michael; Pacureanu, Alexandra; Seung, H. Sebastian; Macrina, Thomas; Lee, Wei-Chung Allen; Tuthill, John C.
  作者单位：University of Washington; University of Washington Seattle; Harvard University; Harvard Medical School; California Institute of Technology; Princeton University; Princeton University; Allen Institute for Brain Science; European Synchrotron Radiation Facility (ESRF); Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
  摘要：A deep understanding of how the brain controls behaviour requires mapping neural circuits down to the muscles that they control. Here, we apply automated tools to segment neurons and identify synapses in an electron microscopy dataset of an adult female Drosophila melanogaster ventral nerve cord (VNC)(1), which functions like the vertebrate spinal cord to sense and control the body. We find that the fly VNC contains roughly 45 million synapses and 14,600 neuronal cell bodies. To interpret the ...