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作者：Krukenberg, Viola; Kohtz, Anthony J.; Jay, Zackary J.; Hatzenpichler, Roland
作者单位：Montana State University System; Montana State University Bozeman; Montana State University System; Montana State University Bozeman; Montana State University System; Montana State University Bozeman
摘要：Methanogenesis mediated by archaea is the main source of methane, a strong greenhouse gas, and thus is critical for understanding Earth's climate dynamics. Recently, genes encoding diverse methanogenesis pathways have been discovered in metagenome-assembled genomes affiliated with several archaeal phyla1-7. However, all experimental studies on methanogens are at present restricted to cultured representatives of the Euryarchaeota. Here we show methanogenic growth by a member of the lineage Kora...
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作者：Adarsh, S.; Shamla, D. S.; Nair, G. R. Arathy; Mohan, Meera G.
作者单位：Thangal Kunju Musaliar College of Engineering
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作者：Sala, Enric
作者单位：National Geographic Society
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作者：Chen, Wei; Choi, Junhong; Li, Xiaoyi; Nathans, Jenny F.; Martin, Beth; Yang, Wei; Hamazaki, Nobuhiko; Qiu, Chengxiang; Lalanne, Jean-Benoit; Regalado, Samuel; Kim, Haedong; Agarwal, Vikram; Nichols, Eva; Leith, Anh; Lee, Choli; Shendure, Jay
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Memorial Sloan Kettering Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Measurements of gene expression or signal transduction activity are conventionally performed using methods that require either the destruction or live imaging of a biological sample within the timeframe of interest. Here we demonstrate an alternative paradigm in which such biological activities are stably recorded to the genome. Enhancer-driven genomic recording of transcriptional activity in multiplex (ENGRAM) is based on the signal-dependent production of prime editing guide RNAs that mediat...
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作者：Lenharo, Mariana
摘要：Early results from clinical trial show that the antiviral drug tecovirimat is no better than placebo against the clade I virus type.
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作者：Chawla, Dalmeet Singh
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作者：Chen, Chong; Niehaus, Jesse K.; Dinc, Fatih; Huang, Karen L.; Barnette, Alexander L.; Tassou, Adrien; Shuster, S. Andrew; Wang, Lihua; Lemire, Andrew; Menon, Vilas; Ritola, Kimberly; Hantman, Adam W.; Zeng, Hongkui; Schnitzer, Mark J.; Scherrer, Gregory
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; Stanford University; Stanford University; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Columbia University; Allen Institute for Brain Science; Stanford University; Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute
摘要：Placebo effects are notable demonstrations of mind-body interactions(1,2). During pain perception, in the absence of any treatment, an expectation of pain relief can reduce the experience of pain-a phenomenon known as placebo analgesia(3-6). However, despite the strength of placebo effects and their impact on everyday human experience and the failure of clinical trials for new therapeutics(7), the neural circuit basis of placebo effects has remained unclear. Here we show that analgesia from th...
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作者：Mason, Christopher E.; Green, James; Adamopoulos, Konstantinos I.; Afshin, Evan E.; Baechle, Jordan J.; Basner, Mathias; Bailey, Susan M.; Bielski, Luca; Borg, Josef; Borg, Joseph; Broddrick, Jared T.; Burke, Marissa; Caicedo, Andres; Castaneda, Veronica; Chatterjee, Subhamoy; Chin, Christopher R.; Church, George; Costes, Sylvain V.; De Vlaminck, Iwijn; Desai, Rajeev I.; Dhir, Raja; Diaz, Juan Esteban; Etlin, Sofia M.; Feinstein, Zachary; Furman, David; Garcia-Medina, J. Sebastian; Garrett-Bakelman, Francine; Giacomello, Stefania; Gupta, Anjali; Hassanin, Amira; Houerbi, Nadia; Irby, Iris; Javorsky, Emilia; Jirak, Peter; Jones, Christopher W.; Kamal, Khaled Y.; Kangas, Brian D.; Karouia, Fathi; Kim, Jangkeun; Kim, Joo Hyun; Kleinman, Ashley S.; Lam, Try; Lawler, John M.; Lee, Jessica A.; Limoli, Charles L.; Lucaci, Alexander; Mackay, Matthew; Mcdonald, J. Tyson; Melnick, Ari M.; Meydan, Cem; Mieczkowski, Jakub; Muratani, Masafumi; Najjar, Deena; Othman, Mariam A.; Overbey, Eliah G.; Paar, Vera; Park, Jiwoon; Paul, Amber M.; Perdyan, Adrian; Proszynski, Jacqueline; Reynolds, Robert J.; Ronca, April E.; Rubins, Kate; Ryon, Krista A.; Sanders, Lauren M.; Glowe, Patricia Savi; Shevde, Yash; Schmidt, Michael A.; Scott, Ryan T.; Shirah, Bader; Sienkiewicz, Karolina; Sierra, Maria A.; Siew, Keith; Theriot, Corey A.; Tierney, Braden T.; Venkateswaran, Kasthuri; Hirschberg, Jeremy Wain; Walsh, Stephen B.; Walter, Claire; Winer, Daniel A.; Yu, Min; Zea, Luis; Mateus, Jaime; Beheshti, Afshin
作者单位：Cornell University; Weill Cornell Medicine; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; National Technical University of Athens; Buck Institute for Research on Aging; University of Pennsylvania; Colorado State University System; Colorado State University Fort Collins; University of Malta; University of Malta; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; Embry-Riddle Aeronautical University; Universidad San Francisco de Quito; Universidad San Francisco de Quito; Universidad San Francisco de Quito; Universidad de los Andes - Chile; Universidad de los Andes - Chile; Southwest Research Institute; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; University of Zurich; Swiss Institute of Allergy & Asthma Research; Universidad San Francisco de Quito; Cornell University; Buck Institute for Research on Aging; Stanford University; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Austral University; Royal Institute of Technology; Egyptian Knowledge Bank (EKB); Zagazig University; University System of Georgia; Georgia Institute of Technology; Harvard University; Paracelsus Private Medical University; Texas A&M University System; Texas A&M University College Station; Iowa State University; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; Baylor College of Medicine; University of Colorado System; University of Colorado Boulder; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; University of California System; University of California Irvine; Georgetown University; Fahrenheit Universities; Medical University Gdansk; University of Tsukuba; Cornell University; Weill Cornell Medicine; Paracelsus Private Medical University; Stanford University; University of Texas System; University of Texas Medical Branch Galveston; Wake Forest University; Wake Forest Baptist Medical Center; National Aeronautics & Space Administration (NASA); NASA Johnson Space Center; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; King Faisal Specialist Hospital & Research Center; University of London; University College London; University of Southern California; University of Toronto; University of Toronto; University Health Network Toronto; University of Toronto; University System of Maryland; University of Maryland Baltimore; University of Southern California; University of Colorado System; University of Colorado Boulder; SpaceX; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：The recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a 'second space age'. This era is also poised to leverage, for the first time, modern tool...
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作者：Bruni, Gabriele; Piro, Luigi; Yang, Yuan-Pei; Quai, Salvatore; Zhang, Bing; Palazzi, Eliana; Nicastro, Luciano; Feruglio, Chiara; Tripodi, Roberta; O'Connor, Brendan; Gardini, Angela; Savaglio, Sandra; Rossi, Andrea; Guelbenzu, Ana M. Nicuesa; Paladino, Rosita
作者单位：Istituto Nazionale Astrofisica (INAF); Yunnan University; Purple Mountain Observatory, CAS; Chinese Academy of Sciences; Nanjing Institute of Astronomical Optics & Technology, NAOC, CAS; University of Bologna; Istituto Nazionale Astrofisica (INAF); Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; Istituto Nazionale Astrofisica (INAF); University of Trieste; Carnegie Mellon University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Astrofisica de Andalucia (IAA); University of Calabria; Istituto Nazionale di Fisica Nucleare (INFN)
摘要：Fast radio bursts (FRBs) are millisecond-duration, bright (approximately Jy) extragalactic bursts, whose production mechanism is still unclear(1). Recently, two repeating FRBs were found to have a physically associated persistent radio source of non-thermal origin(2,3). These two FRBs have unusually large Faraday rotation measure values(2,3), probably tracing a dense magneto-ionic medium, consistent with synchrotron radiation originating from a nebula surrounding the FRB source(4-8). Recent th...
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作者：Ledford, Heidi
