-
作者：Dias Mirandela, Madeleine; Zoch, Ansgar; Leismann, Jessica; Webb, Shaun; Berrens, Rebecca V.; Valsakumar, Devisree; Kabayama, Yuka; Auchynnikava, Tania; Schito, Martina; Chowdhury, Tamoghna; MacLeod, David; Xiang, Xinyu; Zou, Juan; Rappsilber, Juri; Allshire, Robin C.; Voigt, Philipp; Cook, Atlanta G.; Barau, Joan; O'Carroll, Donal
作者单位：University of Edinburgh; University of Edinburgh; Institute of Molecular Biology (IMB); University of Oxford; University of Oxford; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Babraham Institute; Zhejiang University; Technical University of Berlin; University of Edinburgh
摘要：The PIWI-interacting RNA (piRNA) pathway guides the DNA methylation of young, active transposons during germline development in male mice(1). piRNAs tether the PIWI protein MIWI2 (PIWIL4) to the nascent transposon transcript, resulting in DNA methylation through SPOCD1 (refs. (2-5)). Transposon methylation requires great precision: every copy needs to be methylated but off-target methylation must be avoided. However, the underlying mechanisms that ensure this precision remain unknown. Here, we...
-
作者：Khilkevich, Andrei; Lohse, Michael; Low, Ryan; Orsolic, Ivana; Bozic, Tadej; Windmill, Paige; Mrsic-Flogel, Thomas D.
作者单位：University of London; University College London
摘要：Perceptual decisions rely on learned associations between sensory evidence and appropriate actions, involving the fltering and integration of relevant inputs to prepare and execute timely responses(1,2). Despite the distributed nature of task-relevant representations(3-10), it remains unclear how transformations between sensory input, evidence integration, motor planning and execution are orchestrated across brain areas and dimensions of neural activity. Here we addressed this question by reco...
-
作者：Nicholl, M.; Pasham, D. R.; Mummery, A.; Guolo, M.; Gendreau, K.; Dewangan, G. C.; Ferrara, E. C.; Remillard, R.; Bonnerot, C.; Chakraborty, J.; Hajela, A.; Dhillon, V. S.; Gillan, A. F.; Greenwood, J.; Huber, M. E.; Janiuk, A.; Salvesen, G.; van Velzen, S.; Aamer, A.; Alexander, K. D.; Angus, C. R.; Arzoumanian, Z.; Auchettl, K.; Berger, E.; de Boer, T.; Cendes, Y.; Chambers, K. C.; Chen, T. -W.; Chornock, R.; Fulton, M. D.; Gao, H.; Gillanders, J. H.; Gomez, S.; Gompertz, B. P.; Fabian, A. C.; Herman, J.; Ingram, A.; Kara, E.; Laskar, T.; Lawrence, A.; Lin, C. -C.; Lowe, T. B.; Magnier, E. A.; Margutti, R.; McGee, S. L.; Minguez, P.; Moore, T.; Nathan, E.; Oates, S. R.; Patra, K. C.; Ramsden, P.; Ravi, V.; Ridley, E. J.; Sheng, X.; Smartt, S. J.; Smith, K. W.; Srivastav, S.; Stein, R.; Stevance, H. F.; Turner, S. G. D.; Wainscoat, R. J.; Weston, J.; Wevers, T.; Young, D. R.
作者单位：Queens University Belfast; Massachusetts Institute of Technology (MIT); University of Oxford; Johns Hopkins University; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Inter-University Centre for Astronomy & Astrophysics; University System of Maryland; University of Maryland College Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University of Birmingham; University of Birmingham; University of Copenhagen; Niels Bohr Institute; University of Sheffield; Instituto de Astrofisica de Canarias; University of Hawaii System; Polish Academy of Sciences; Center for Theoretical Physics - Polish Academy of Sciences; United States Department of Energy (DOE); Los Alamos National Laboratory; Leiden University; Leiden University - Excl LUMC; University of Arizona; University of Arizona; University of Melbourne; University of California System; University of California Santa Cruz; Smithsonian Institution; University of Oregon; National Central University; University of California System; University of California Berkeley; University of Oxford; Space Telescope Science Institute; University of Cambridge; Newcastle University - UK; Utah System of Higher Education; University of Utah; Radboud University Nijmegen; University of Edinburgh; California Institute of Technology; Lancaster University; California Institute of Technology; University of Cambridge
摘要：Quasi-periodic eruptions (QPEs) are luminous bursts of soft X-rays from the nuclei of galaxies, repeating on timescales of hours to weeks(1-5). The mechanism behind these rare systems is uncertain, but most theories involve accretion disks around supermassive black holes (SMBHs) undergoing instabilities(6-8) or interacting with a stellar object in a close orbit(9-11). It has been suggested that this disk could be created when the SMBH disrupts a passing star(8,11), implying that many QPEs shou...
-
作者：Dickopf, Stefan; Sikora, Bastian; Kaiser, Annabelle; Mueller, Marius; Ulmer, Stefan; Yerokhin, Vladimir A.; Harman, Zoltan; Keitel, Christoph H.; Mooser, Andreas; Blaum, Klaus
-
作者：Nowogrodzki, Julian
摘要：Evidence shows that blockbuster weight-loss medications can reduce obesity even in children aged 6-11 years, but their long-term effects on growing bodies are unknown. Evidence shows that blockbuster weight-loss medications can reduce obesity even in children aged 6-11, but their long-term effects on growing bodies are unknown.
-
作者：[Anonymous]
-
作者：Wei, Shaolou; Ma, Yan; Raabe, Dierk
摘要：Metallurgical production traditionally involves three steps: extracting metals from ores, mixing them into alloys by liquid processing and thermomechanical processing to achieve the desired microstructures(1,2). This sequential approach, practised since the Bronze Age, reaches its limit today because of the urgent demand for a sustainable economy(2-5): almost 10% of all greenhouse gas emissions are because of the use of fossil reductants and high-temperature metallurgical processing. Here we p...
-
作者：Lin, Baichen; Ong, Khuong Phuong; Yang, Tiannan; Zeng, Qibin; Hui, Hui Kim; Ye, Zhen; Sim, Celine; Yen, Zhihao; Yang, Ping; Dou, Yanxin; Li, Xiaolong; Gao, Xingyu; Tan, Chee Kiang Ivan; Lim, Zhi Shiuh; Zeng, Shengwei; Luo, Tiancheng; Xu, Jinlong; Tong, Xin; Li, Patrick Wen Feng; Ren, Minqin; Zeng, Kaiyang; Sun, Chengliang; Ramakrishna, Seeram; Breese, Mark B. H.; Boothroyd, Chris; Lee, Chengkuo; Singh, David J.; Lam, Yeng Ming; Liu, Huajun
作者单位：Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Materials Research & Engineering (IMRE); Nanyang Technological University; Agency for Science Technology & Research (A*STAR); A*STAR - Institute of High Performance Computing (IHPC); Shanghai Jiao Tong University; National University of Singapore; National University of Singapore; National University of Singapore; Chinese Academy of Sciences; Shanghai Advanced Research Institute, CAS; National University of Singapore; Wuhan University; Nanyang Technological University; University of Missouri System; University of Missouri Columbia
摘要：Materials with electromechanical coupling are essential for transducers and acoustic devices as reversible converters between mechanical and electrical energy(1-6). High electromechanical responses are typically found in materials with strong structural instabilities, conventionally achieved by two strategies-morphotropic phase boundaries(7) and nanoscale structural heterogeneity(8). Here we demonstrate a different strategy to accomplish ultrahigh electromechanical response by inducing extreme...
-
作者：Ryu, Jae Kyu; Yan, Zhaoqi; Montano, Mauricio; Sozmen, Elif G.; Dixit, Karuna; Suryawanshi, Rahul K.; Matsui, Yusuke; Helmy, Ekram; Kaushal, Prashant; Makanani, Sara K.; Deerinck, Thomas J.; Meyer-Franke, Anke; Coronado, Pamela E. Rios; Trevino, Troy N.; Shin, Min-Gyoung; Tognatta, Reshmi; Liu, Yixin; Schuck, Renaud; Le, Lucas; Miyajima, Hisao; Mendiola, Andrew S.; Arun, Nikhita; Guo, Brandon; Taha, Taha Y.; Agrawal, Ayushi; MacDonald, Eilidh; Aries, Oliver; Yan, Aaron; Weaver, Olivia; Petersen, Mark A.; Acevedo, Rosa Meza; Alzamora, Maria del Pilar S.; Thomas, Reuben; Traglia, Michela; Kouznetsova, Valentina L.; Tsigelny, Igor F.; Pico, Alexander R.; Red-Horse, Kristy; Ellisman, Mark H.; Krogan, Nevan J.; Bouhaddou, Mehdi; Ott, Melanie; Greene, Warner C.; Akassoglou, Katerina
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California San Diego; Stanford University; University of California System; University of California San Francisco; University of California System; University of California San Diego; University of California System; University of California San Diego; Stanford University; Howard Hughes Medical Institute; Stanford University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Chan Zuckerberg Initiative (CZI); University of California System; University of California San Francisco
摘要：Life-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 and are persistent in patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection1-4. Despite the clinical evidence1,5-7, the underlying mechanisms of coagulopathy in COVID-19 and its consequences in inflammation and neuropathology remain poorly understood and treatment options are insufficient. Fibrinogen, the central structural component of blood clots, is abundantly deposited in the ...
-
作者：Callaway, Ewen
摘要：Protein structures predicted by artificial intelligence have charted the evolution of the virus family responsible for dengue and hepatitis C. Protein structures predicted by artificial intelligence have charted the evolution of the virus family responsible for dengue and hepatitis C.
