Brain-wide dynamics linking sensation to action during decision-making
成果类型：
Article
署名作者：
Khilkevich, Andrei; Lohse, Michael; Low, Ryan; Orsolic, Ivana; Bozic, Tadej; Windmill, Paige; Mrsic-Flogel, Thomas D.
署名单位：
University of London; University College London
刊物名称：
Nature
ISSN/ISSBN：
0028-6692
DOI：
10.1038/s41586-024-07908-w
发表日期：
2024-10-01
页码：
890-900
关键词：
摘要：
Perceptual decisions rely on learned associations between sensory evidence and appropriate actions, involving the fltering and integration of relevant inputs to prepare and execute timely responses(1,2). Despite the distributed nature of task-relevant representations(3-10), it remains unclear how transformations between sensory input, evidence integration, motor planning and execution are orchestrated across brain areas and dimensions of neural activity. Here we addressed this question by recording brain-wide neural activity in mice learning to report changes in ambiguous visual input. After learning, evidence integration emerged across most brain areas in sparse neural populations that drive movement-preparatory activity. Visual responses evolved from transient activations in sensory areas to sustained representations in frontal-motor cortex, thalamus, basal ganglia, midbrain and cerebellum, enabling parallel evidence accumulation. In areas that accumulate evidence, shared population activity patterns encode visual evidence and movement preparation, distinct from movement-execution dynamics. Activity in movement-preparatory subspace is driven by neurons integrating evidence, which collapses at movement onset, allowing the integration process to reset. Across premotor regions, evidence-integration timescales were independent of intrinsic regional dynamics, and thus depended on task experience. In summary, learning aligns evidence accumulation to action preparation in activity dynamics across dozens of brain regions. This leads to highly distributed and parallelized sensorimotor transformations during decision-making. Our work unifes concepts from decision-making and motor control felds into a brain-wide framework for understanding how sensory evidence controls actions.