-
作者：Sorbie, Jonathan A.; Diao, Tianning
作者单位：New York University
-
作者：Franks, Kevin M.; Schaefer, Andreas T.
作者单位：Duke University; Francis Crick Institute
摘要：What is the neural basis of our perceptual experience? Simultaneous recordings from many individual neurons in humans provide surprising insights into how odours are processed in different regions of the brain.
-
作者：Broz, M.; Vernazza, P.; Marsset, M.; DeMeo, F. E.; Binzel, R. P.; Vokrouhlicky, D.; Nesvorny, D.
作者单位：Charles University Prague; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Massachusetts Institute of Technology (MIT); Southwest Research Institute
摘要：Understanding the origin of bright shooting stars and their meteorite samples is among the most ancient of astronomy-related questions, which at larger scales has human consequences(1-3). As of today, only approximately 6% of meteorite falls have been firmly linked to their sources (Moon, Mars or asteroid (4) Vesta(4-6)). Here we show that approximately 70% of meteorites originate from three recent break-ups of D > 30 km asteroids that occurred 5.8, 7.6 and less than about 40 Myr ago. These br...
-
作者：Granvik, Mikael
作者单位：University of Helsinki; Lulea University of Technology
摘要：Researchers have narrowed down the sources of the most common types of meteorite to a few collisional events that happened much more recently than was previously thought.
-
作者：Bu, Faxiang; Deng, Yuqi; Xu, Jie; Yang, Dali; Li, Yan; Li, Wu; Lei, Aiwen
作者单位：Wuhan University
摘要：The incorporation of deuterium in organic molecules has widespread applications in medicinal chemistry and materials science1,2. For example, the deuterated drugs austedo3, donafenib4 and sotyktu5 have been recently approved. There are various methods for the synthesis of deuterated compounds with high deuterium incorporation6. However, the reductive deuteration of aromatic hydrocarbons-ubiquitous chemical feedstocks-to saturated cyclic compounds has rarely been achieved. Here we describe a sc...
-
作者：Diana, Zoie T.; Rochman, Chelsea M.; Mallos, Nicholas
作者单位：University of Toronto
-
作者：Nowogrodzki, Julian
-
作者：Bai, Zhiliang; Feng, Bing; McClory, Susan E.; de Oliveira, Beatriz Coutinho; Diorio, Caroline; Gregoire, Celine; Tao, Bo; Yang, Luojia; Zhao, Ziran; Peng, Lei; Sferruzza, Giacomo; Zhou, Liqun; Zhou, Xiaolei; Kerr, Jessica; Baysoy, Alev; Su, Graham; Yang, Mingyu; Camara, Pablo G.; Chen, Sidi; Tang, Li; June, Carl H.; Melenhorst, J. Joseph; Grupp, Stephan A.; Fan, Rong
作者单位：Yale University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Cleveland Clinic Foundation; Yale University; Yale University; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Yale University; Yale University; Yale University; Yale New Haven Hospital
摘要：Despite a high response rate in chimeric antigen receptor (CAR) T cell therapy for acute lymphocytic leukaemia (ALL)(1-3), approximately 50% of patients relapse within the first year(4-6), representing an urgent question to address in the next stage of cellular immunotherapy. Here, to investigate the molecular determinants of ultralong CAR T cell persistence, we obtained a single-cell multi-omics atlas from 695,819 pre-infusion CAR T cells at the basal level or after CAR-specific stimulation f...
-
作者：Xu, Guobao; Broadman, Ellie; Dorado-Linan, Isabel; Klippel, Lara; Meko, Matthew; Buntgen, Ulf; De Mil, Tom; Esper, Jan; Gunnarson, Bjorn; Hartl, Claudia; Krusic, Paul J.; Linderholm, Hans W.; Ljungqvist, Fredrik C.; Ludlow, Francis; Panayotov, Momchil; Seim, Andrea; Wilson, Rob; Zamora-Reyes, Diana; Trouet, Valerie
作者单位：Northwest University Xi'an; University of Arizona; Chinese Academy of Sciences; Universidad Politecnica de Madrid; Deutscher Wetterdienst; University of Cambridge; Czech Academy of Sciences; Global Change Research Centre of the Czech Academy of Sciences; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Masaryk University; University of Liege; Johannes Gutenberg University of Mainz; Stockholm University; Justus Liebig University Giessen; Stockholm University; University of Gothenburg; Stockholm University; Swedish Collegium for Advanced Study (SCAS); Trinity College Dublin; Trinity College Dublin; University of Forestry - Bulgaria; University of Freiburg; University of Innsbruck; University of St Andrews
摘要：The jet stream is an important dynamic driver of climate variability in the Northern Hemisphere mid-latitudes(1-3). Modern variability in the position of summer jet stream latitude in the North Atlantic-European sector (EU JSL) promotes dipole patterns in air pressure, temperature, precipitation and drought between northwestern and southeastern Europe. EU JSL variability and its impacts on regional climatic extremes and societal events are poorly understood, particularly before anthropogenic w...
-
作者：Clifton, Ben E.; Alcolombri, Uria; Uechi, Gen-Ichiro; Jackson, Colin J.; Laurino, Paola
作者单位：Okinawa Institute of Science & Technology Graduate University; Hebrew University of Jerusalem; Australian National University; Australian National University; Australian National University; University of Osaka
摘要：SAR11 bacteria are the most abundant microorganisms in the surface ocean(1) and have global biogeochemical importance(2-4). To thrive in their competitive oligotrophic environment, these bacteria rely heavily on solute-binding proteins that facilitate uptake of specific substrates via membrane transporters(5,6). The functions and properties of these transport proteins are key factors in the assimilation of dissolved organic matter and biogeochemical cycling of nutrients in the ocean, but they ...
