Nature

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• The type 2 cytokine Fc-IL-4 revitalizes exhausted CD8+ T cells against cancer AI翻译
  作者：Feng, Bing; Bai, Zhiliang; Zhou, Xiaolei; Zhao, Yang; Xie, Yu-Qing; Huang, Xinyi; Liu, Yang; Enbar, Tom; Li, Rongrong; Wang, Yi; Gao, Min; Bonati, Lucia; Peng, Mei-Wen; Li, Weilin; Tao, Bo; Charmoy, Melanie; Held, Werner; Melenhorst, J. Joseph; Fan, Rong; Guo, Yugang; Tang, Li
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Yale University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Yale University; University of Lausanne; Cleveland Clinic Foundation; Zhejiang University; Zhejiang University; Zhejiang University
  摘要：Current cancer immunotherapy predominately focuses on eliciting type 1 immune responses fighting cancer; however, long-term complete remission remains uncommon(1,2). A pivotal question arises as to whether type 2 immunity can be orchestrated alongside type 1-centric immunotherapy to achieve enduring response against cancer(3,4). Here we show that an interleukin-4 fusion protein (Fc-IL-4), a typical type 2 cytokine, directly acts on CD8(+) T cells and enriches functional terminally exhausted CD...
• MARBURG VIRUS IS RISING IN RWANDA: WHY SCIENTISTS ARE WORRIED AI翻译
  作者：Sidik, Saima
• Evidence of dead people posed on dead horses found in ancient tomb AI翻译
  作者：[Anonymous]
• Differences in misinformation sharing can lead to politically asymmetric sanctions AI翻译
  作者：Mosleh, Mohsen; Yang, Qi; Zaman, Tauhid; Pennycook, Gordon; Rand, David G.
  作者单位：University of Oxford; University of Exeter; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Yale University; Cornell University; Massachusetts Institute of Technology (MIT)
  摘要：In response to intense pressure, technology companies have enacted policies to combat misinformation(1-4). The enforcement of these policies has, however, led to technology companies being regularly accused of political bias(5-7). We argue that differential sharing of misinformation by people identifying with different political groups(8-15) could lead to political asymmetries in enforcement, even by unbiased policies. We first analysed 9,000 politically active Twitter users during the US 2020...
• High-performance 4-nm-resolution X-ray tomography using burst ptychography (vol 632, pg 81, 2024) AI翻译
  作者：Aidukas, Tomas; Phillips, Nicholas W.; Diaz, Ana; Poghosyan, Emiliya; Muller, Elisabeth; Levi, A. F. J.; Aeppli, Gabriel; Guizar-Sicairos, Manuel; Holler, Mirko
• Molecular programs guiding arealization of descending cortical pathways AI翻译
  作者：Abe, Philipp; Lavalley, Adrien; Morassut, Ilaria; Santinha, Antonio J.; Roig-Puiggros, Sergi; Javed, Awais; Klingler, Esther; Baumann, Natalia; Prados, Julien; Platt, Randall J.; Jabaudon, Denis
  作者单位：University of Geneva; Technische Universitat Dresden; Carl Gustav Carus University Hospital; University of Geneva; Swiss Federal Institutes of Technology Domain; ETH Zurich; Flanders Institute for Biotechnology (VIB); University of Geneva; University of Basel; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite
  摘要：Layer 5 extratelencephalic (ET) neurons are present across neocortical areas and send axons to multiple subcortical targets1-6. Two cardinal subtypes exist7,8: (1) Slco2a1-expressing neurons (ETdist), which predominate in the motor cortex and project distally to the pons, medulla and spinal cord; and (2) Nprs1- or Hpgd-expressing neurons (ETprox), which predominate in the visual cortex and project more proximally to the pons and thalamus. An understanding of how area-specific ETdist and ETprox...
• Engineered T cell therapy for central nervous system injury AI翻译
  作者：Gao, Wenqing; Kim, Min Woo; Dykstra, Taitea; Du, Siling; Boskovic, Pavle; Lichti, Cheryl F.; Ruiz-Cardozo, Miguel A.; Gu, Xingxing; Weizman Shapira, Tal; Rustenhoven, Justin; Molina, Camilo; Smirnov, Igor; Merbl, Yifat; Ray, Wilson Z.; Kipnis, Jonathan
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Saint Louis University; Washington University (WUSTL); Weizmann Institute of Science
  摘要：Traumatic injuries to the central nervous system (CNS) afflict millions of individuals worldwide1, yet an effective treatment remains elusive. Following such injuries, the site is populated by a multitude of peripheral immune cells, including T cells, but a comprehensive understanding of the roles and antigen specificity of these endogenous T cells at the injury site has been lacking. This gap has impeded the development of immune-mediated cellular therapies for CNS injuries. Here, using singl...
• DEVELOPERS OF ALPHAFOLD WIN CHEMISTRY NOBEL AI翻译
  作者：Callaway, Ewen
• Conflict in New Caledonia endangers one of the world's biodiversity hotspots AI翻译
  作者：Oedin, Malik; Dombal, Yvy
• Revolutionary drug for schizophrenia wins US approval AI翻译
  作者：Dolgin, Elie