Nature

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• Local government actions can curb air pollution in India and Pakistan AI翻译
  作者：Balsari, Satchit; Mohanan, Manoj
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Duke University
  摘要：Burning crop waste causes devastating pollution in South Asia. When local administrators have appropriate incentives to control burning, incidents go down - a finding that could guide future efforts to manage air pollution.
• How to spend one trillion dollars: the US decarbonization conundrum AI翻译
  作者：Christensen, Peter; Baylis, Patrick; Garg, Teevrat; Li, Shanjun; Mccord, Gordon C.; Muehlegger, Erich; Myers, Erica; Noble Smith, Emma; Rapson, David S.
  作者单位：University of California System; University of California Santa Cruz; University of British Columbia; University of California System; University of California San Diego; Cornell University; University of California System; University of California San Diego; University of Calgary; University of Oxford; Federal Reserve System - USA; Federal Reserve Bank - Dallas; University of California System; University of California Davis
  摘要：Why we must treat decarbonization policies as an experiment and put in place measures now to evaluate what works best.
• The world needs a US president who respects evidence AI翻译
  作者：[Anonymous]
• Journals with high rates of suspicious papers flagged by science-integrity start-up AI翻译
  作者：Van Noorden, Richard
• Bureaucrat incentives reduce crop burning and child mortality in South Asia AI翻译
  作者：Dipoppa, Gemma; Gulzar, Saad
  作者单位：Brown University; Princeton University
  摘要：Air pollution in South Asia is a health emergency, responsible for 2 million deaths every year1. Crop residue burning accounts for 40-60% of peak pollution during the winter harvest months2,3. Despite being illegal, this practice remains widespread4,5. Any solution to curb the problem necessitates government action at scale. Here we study whether leveraging the incentives of bureaucrats tasked with controlling burning can mitigate this phenomenon. Using a decade of wind, fire and health data f...
• Gasdermin D-mediated metabolic crosstalk promotes tissue repair AI翻译
  作者：Chi, Zhexu; Chen, Sheng; Yang, Dehang; Cui, Wenyu; Lu, Yang; Wang, Zhen; Li, Mobai; Yu, Weiwei; Zhang, Jian; Jiang, Yu; Sun, Ruya; Yu, Qianzhou; Hu, Tianyi; Lu, Xiaoyang; Deng, Qiqi; Yang, Yidong; Zhao, Tianming; Chang, Mengfei; Li, Yuying; Zhang, Xue; Shang, Min; Xiao, Qian; Ding, Kefeng; Wang, Di
  作者单位：Zhejiang University; Zhejiang University; Liangzhu Laboratory; Zhejiang University; Zhejiang University; Zhejiang University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Zhejiang University; Zhejiang University
  摘要：The establishment of an early pro-regenerative niche is crucial for tissue regeneration1,2. Gasdermin D (GSDMD)-dependent pyroptosis accounts for the release of inflammatory cytokines upon various insults3-5. However, little is known about its role in tissue regeneration followed by homeostatic maintenance. Here we show that macrophage GSDMD deficiency delays tissue recovery but has little effect on the local inflammatory milieu or the lytic pyroptosis process. Profiling of the metabolite secr...
• Tumour evolution and microenvironment interactions in 2D and 3D space AI翻译
  作者：Mo, Chia-Kuei; Liu, Jingxian; Chen, Siqi; Storrs, Erik; Targino da Costa, Andre Luiz N.; Houston, Andrew; Wendl, Michael C.; Jayasinghe, Reyka G.; Iglesia, Michael D.; Ma, Cong; Herndon, John M.; Southard-Smith, Austin N.; Liu, Xinhao; Mudd, Jacqueline; Karpova, Alla; Shinkle, Andrew; Goedegebuure, S. Peter; Abdelzaher, Abdurrahman Taha Mousa Ali; Bo, Peng; Fulghum, Lauren; Livingston, Samantha; Balaban, Metin; Hill, Angela; Ippolito, Joseph E.; Thorsson, Vesteinn; Held, Jason M.; Hagemann, Ian S.; Kim, Eric H.; Bayguinov, Peter O.; Kim, Albert H.; Mullen, Mary M.; Shoghi, Kooresh I.; Ju, Tao; Reimers, Melissa A.; Weimholt, Cody; Kang, Liang-, I; Puram, Sidharth V.; Veis, Deborah J.; Pachynski, Russell; Fuh, Katherine C.; Chheda, Milan G.; Gillanders, William E.; Fields, Ryan C.; Raphael, Benjamin J.; Chen, Feng; Ding, Li
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Princeton University; Washington University (WUSTL); Washington University (WUSTL); Siteman Cancer Center; Washington University (WUSTL); Institute for Systems Biology (ISB); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of California System; University of California San Francisco
  摘要：To study the spatial interactions among cancer and non-cancer cells1, we here examined a cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial transcriptomics (ST). This was combined with 48 matched single-nucleus RNA sequencing samples and 22 matched co-detection by indexing (CODEX) samples. To describe tumour structures and habitats, we defined 'tumour microregions' as spatially distinct cancer cell clusters separated by stromal components. They varied in size a...
• Selective utilization of glucose metabolism guides mammalian gastrulation AI翻译
  作者：Cao, Dominica; Bergmann, Jenna; Zhong, Liangwen; Hemalatha, Anupama; Dingare, Chaitanya; Jensen, Tyler; Cox, Andy L.; Greco, Valentina; Steventon, Benjamin; Sozen, Berna
  作者单位：Yale University; University of Cambridge; Yale University; Yale University; Yale University; Howard Hughes Medical Institute; Yale University
  摘要：The prevailing dogma for morphological patterning in developing organisms argues that the combined inputs of transcription factor networks and signalling morphogens alone generate spatially and temporally distinct expression patterns. However, metabolism has also emerged as a critical developmental regulator1-10, independent of its functions in energy production and growth. The mechanistic role of nutrient utilization in instructing cellular programmes to shape the in vivo developing mammalian...
• 'ANONYMOUS' GENETIC DATABASES VULNERABLE TO PRIVACY LEAKS AI翻译
  作者：Kudiabor, Helena
• Consider the ethical impacts of quantum technologies in defence - before it's too late AI翻译
  作者：Taddeo, Mariarosaria; Blanchard, Alexander; Pundyk, Kate
  作者单位：University of Oxford; Alan Turing Institute; University of Oxford