Nature

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• Farmed fur animals harbour viruses with zoonotic spillover potential AI翻译
  作者：Zhao, Jin; Wan, Wenbo; Yu, Kang; Lemey, Philippe; Pettersson, John H. -O.; Bi, Yuhai; Lu, Meng; Li, Xinxin; Chen, Zhuohang; Zheng, Mengdi; Yan, Ge; Dai, Jianjun; Li, Yuxing; Haerheng, Ayidana; He, Na; Tu, Changchun; Suchard, Marc A.; Holmes, Edward C.; He, Wan-Ting; Su, Shuo
  作者单位：Fudan University; China Pharmaceutical University; KU Leuven; Uppsala University; Uppsala University; Uppsala University Hospital; University of Melbourne; Peter Doherty Institute; Chinese Academy of Sciences; Institute of Microbiology, CAS; Nanjing Agricultural University; Chinese Academy of Agricultural Sciences; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of Sydney
  摘要：Animals such as raccoon dogs, mink and muskrats are farmed for fur and are sometimes used as food or medicinal products1,2, yet they are also potential reservoirs of emerging pathogens3. Here we performed single-sample metatranscriptomic sequencing of internal tissues from 461 individual fur animals that were found dead due to disease. We characterized 125 virus species, including 36 that were novel and 39 at potentially high risk of cross-species transmission, including zoonotic spillover. No...
• Encoding of female mating dynamics by a hypothalamic line attractor AI翻译
  作者：Liu, Mengyu; Nair, Aditya; Coria, Nestor; Linderman, Scott W.; Anderson, David J.
  作者单位：California Institute of Technology; California Institute of Technology; Howard Hughes Medical Institute; Stanford University; Stanford University
  摘要：Females exhibit complex, dynamic behaviours during mating with variable sexual receptivity depending on hormonal status1-4. However, how their brains encode the dynamics of mating and receptivity remains largely unknown. The ventromedial hypothalamus, ventrolateral subdivision contains oestrogen receptor type 1-positive neurons that control mating receptivity in female mice5,6. Here, unsupervised dynamical system analysis of calcium imaging data from these neurons during mating uncovered a dim...
• Removing Bias from Devices and Diagnostics Can Save Lives AI翻译
  作者：Willyard, Cassandra
• The discovery that stuck-20 years of graphene AI翻译
  作者：Jarillo-Herrero, Pablo
  作者单位：Massachusetts Institute of Technology (MIT)
  摘要：In 2004, physicists reported something remarkable: they had isolated ultrathin films of carbon atoms using sticky tape alone, and found that the films had astounding properties. The finding would forever change condensed-matter physics.
• Parallel molecular data storage by printing epigenetic bits on DNA AI翻译
  作者：Zhang, Cheng; Wu, Ranfeng; Sun, Fajia; Lin, Yisheng; Liang, Yuan; Teng, Jiongjiong; Liu, Na; Ouyang, Qi; Qian, Long; Yan, Hao
  作者单位：Peking University; Peking University; North China Electric Power University; University of Stuttgart; Max Planck Society; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe
  摘要：DNA storage has shown potential to transcend current silicon-based data storage technologies in storage density, longevity and energy consumption1-3. However, writing large-scale data directly into DNA sequences by de novo synthesis remains uneconomical in time and cost4. We present an alternative, parallel strategy that enables the writing of arbitrary data on DNA using premade nucleic acids. Through self-assembly guided enzymatic methylation, epigenetic modifications, as information bits, ca...
• Harnessing plasticity in sequential metamaterials for ideal shock absorption AI翻译
  作者：Liu, Wenfeng; Janbaz, Shahram; Dykstra, David; Ennis, Bernard; Coulais, Corentin
  作者单位：University of Amsterdam
  摘要：Mechanical metamaterials exhibit interesting properties such as high stiffness at low density1-3, enhanced energy absorption3,4, shape morphing5-7, sequential deformations8-11, auxeticity12-14 and robust waveguiding15,16. Until now, metamaterial design has primarily relied on geometry, and materials nonlinearities such as viscoelasticity, fracture and plasticity have been largely left out of the design rationale. In fact, plastic deformations have been traditionally seen as a failure mode and ...
• Causal evidence of a line attractor encoding an affective state AI翻译
  作者：Vinograd, Amit; Nair, Aditya; Kim, Joseph H.; Linderman, Scott W.; Anderson, David J.
  作者单位：California Institute of Technology; California Institute of Technology; Howard Hughes Medical Institute; Stanford University; Stanford University
  摘要：Continuous attractors are an emergent property of neural population dynamics that have been hypothesized to encode continuous variables such as head direction and eye position1-4. In mammals, direct evidence of neural implementation of a continuous attractor has been hindered by the challenge of targeting perturbations to specific neurons within contributing ensembles2,3. Dynamical systems modelling has revealed that neurons in the hypothalamus exhibit approximate line-attractor dynamics in ma...
• History Lessons Clinics and public health researchers are taking direct aim at the mpox outbreak by starting in local clinics and using tools that were developed to tackle HIV/AIDS AI翻译
  作者：Ebikeme, Charles
• The Staggering Success of Vaccines AI翻译
  作者：Haelle, Tara
• Electric cars could save billions in health-care costs AI翻译
  作者：Klopper, Abigail
  摘要：Improving air quality by discontinuing combustion-engine vehicles would slash health-care costs in the United States, but the projected savings in rural areas depend on how the replacements are powered.