Nature

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• Why a fortunate few don't get ill after HIV infection AI翻译
  作者：[Anonymous]
• A graphite thermal Tesla valve driven by hydrodynamic phonon transport AI翻译
  作者：Huang, Xin; Anufriev, Roman; Jalabert, Laurent; Watanabe, Kenji; Taniguchi, Takashi; Guo, Yangyu; Ni, Yuxiang; Volz, Sebastian; Nomura, Masahiro
  作者单位：University of Tokyo; Institut National des Sciences Appliquees de Lyon - INSA Lyon; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); University of Tokyo; National Institute for Materials Science; National Institute for Materials Science; Harbin Institute of Technology; Southwest Jiaotong University
  摘要：The Tesla valve benefits the rectification of fluid flow in microfluidic systems1-6 and inspires researchers to design modern solid-state electronic and thermal rectifiers referring to fluid-rectification mechanisms in a liquid-state context. In contrast to the rectification of fluids in microfluidic channels, the rectification of thermal phonons in micro-solid channels presents increased complexity owing to the lack of momentum-conserving collisions between phonons and the infrequent occurren...
• Softening of the optical phonon by reduced interatomic bonding strength without depolarization AI翻译
  作者：Cao, Ruyue; Yang, Qiao-Lin; Deng, Hui-Xiong; Wei, Su-Huai; Robertson, John; Luo, Jun-Wei
  作者单位：Chinese Academy of Sciences; Institute of Semiconductors, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Cambridge; Eastern Institute of Technology, Ningbo
  摘要：Softening of the transverse optical (TO) phonon, which could trigger ferroelectric phase transition, can usually be achieved by enhancing the long-range Coulomb interaction over the short-range bonding force1, for example, by increasing the Born effective charges2. However, it suffers from depolarization effects3,4 as the induced ferroelectricity is suppressed on size reduction of the host materials towards high-density nanoscale electronics. Here, we present an alternative route to drive the ...
• Machine-guided design of cell-type-targeting cis-regulatory elements AI翻译
  作者：Gosai, Sager J.; Castro, Rodrigo I.; Fuentes, Natalia; Butts, John C.; Mouri, Kousuke; Alasoadura, Michael; Kales, Susan; Nguyen, Thanh Thanh L.; Noche, Ramil R.; Rao, Arya S.; Joy, Mary T.; Sabeti, Pardis C.; Reilly, Steven K.; Tewhey, Ryan
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Howard Hughes Medical Institute; Jackson Laboratory; Harvard University; University of Maine System; University of Maine Orono; Yale University; Yale University; Yale University; Harvard University; Harvard Medical School; Harvard University; Harvard T.H. Chan School of Public Health; Yale University; Tufts University
  摘要：Cis-regulatory elements (CREs) control gene expression, orchestrating tissue identity, developmental timing and stimulus responses, which collectively define the thousands of unique cell types in the body1-3. While there is great potential for strategically incorporating CREs in therapeutic or biotechnology applications that require tissue specificity, there is no guarantee that an optimal CRE for these intended purposes has arisen naturally. Here we present a platform to engineer and validate...
• AI-designed DNA sequences regulate cell-type-specific gene expression AI翻译
  作者：Pfenning, Andreas R.
  作者单位：Carnegie Mellon University; Carnegie Mellon University
  摘要：Researchers have used artificial-intelligence models to create regulatory DNA sequences that drive gene expression in specific cell types. Such synthetic sequences could be used to target gene therapies to particular cell populations.
• Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy (vol 615, pg 668, 2023) AI翻译
  作者：Chen, Xiaoying; Firulyova, Maria; Manis, Melissa; Herz, Jasmin; Smirnov, Igor; Aladyeva, Ekaterina; Wang, Chanung; Bao, Xin; Finn, Mary Beth; Hu, Hao; Shchukina, Irina; Kim, Min Woo; Yuede, Carla M.; Kipnis, Jonathan; Artyomov, Maxim N.; Ulrich, Jason D.; Holtzman, David M.
  作者单位：Washington University (WUSTL); Almazov National Medical Research Centre; Washington University (WUSTL); Washington University (WUSTL)
• UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis ( vol 571, pg 127, 2019) AI翻译
  作者：Wang, Xiongjun; Liu, Ruilong; Zhu, Wencheng; Chu, Huiying; Yu, Hua; Wei, Ping; Wu, Xueyuan; Zhu, Hongwen; Gao, Hong; Liang, Ji; Li, Guohui; Yang, Weiwei
• Extreme fire seasons are looming - science can help us adapt AI翻译
  作者：Balch, Jennifer K.; Williams, A. Park
  作者单位：University of Colorado System; University of Colorado Boulder; University of California System; University of California Los Angeles
• A thaw in scientific relations could help clear the air in India and Pakistan AI翻译
  作者：[Anonymous]
  摘要：The annual toxic smog that forms over swathes of India and Pakistan is preventable, but the nations' scientists have too little opportunity to help tackle the problem.
• Surprisingly high-altitude Silk Road city mapped from the sky AI翻译
  作者：Silvia, Zachary W.
  作者单位：Brown University
  摘要：The lidar method for aerial archaeology identifies human-modified landscapes. Detection of a massive urban settlement on a mountainous Uzbekistan site challenges preconceptions about medieval urbanization high in Central Asia.