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• Charge-neutral electronic excitations in quantum insulators AI翻译
  作者：Wu, Sanfeng; Schoop, Leslie M.; Sodemann, Inti; Moessner, Roderich; Cava, Robert J.; Ong, N. P.
  作者单位：Princeton University; Princeton University; Leipzig University; Max Planck Society
  摘要：Experiments on quantum materials have uncovered many interesting quantum phases ranging from superconductivity to a variety of topological quantum matter including the recently observed fractional quantum anomalous Hall insulators. The findings have come in parallel with the development of approaches to probe the rich excitations inherent in such systems. In contrast to observing electrically charged excitations, the detection of charge-neutral electronic excitations in condensed matter remain...
• Accelerated formation of ultra-massive galaxies in the first billion years AI翻译
  作者：Xiao, Mengyuan; Oesch, Pascal A.; Elbaz, David; Bing, Longji; Nelson, Erica J.; Weibel, Andrea; Illingworth, Garth D.; van Dokkum, Pieter; Naidu, Rohan P.; Daddi, Emanuele; Bouwens, Rychard J.; Matthee, Jorryt; Wuyts, Stijn; Chisholm, John; Brammer, Gabriel; Dickinson, Mark; Magnelli, Benjamin; Leroy, Lucas; Schaerer, Daniel; Herard-Demanche, Thomas; Lim, Seunghwan; Barrufet, Laia; Endsley, Ryan; Fudamoto, Yoshinobu; Gomez-Guijarro, Carlos; Gottumukkala, Rashmi; Labbe, Ivo; Magee, Dan; Marchesini, Danilo; Maseda, Michael; Qin, Yuxiang; Reddy, Naveen A.; Shapley, Alice; Shivaei, Irene; Shuntov, Marko; Stefanon, Mauro; Whitaker, Katherine E.; Wyithe, J. Stuart B.
  作者单位：University of Geneva; University of Copenhagen; Niels Bohr Institute; Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; University of Sussex; University of Colorado System; University of Colorado Boulder; University of California System; University of California Santa Cruz; Yale University; Massachusetts Institute of Technology (MIT); Leiden University; Leiden University - Excl LUMC; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Bath; University of Texas System; University of Texas Austin; University of Cambridge; University of Cambridge; Waseda University; National Institutes of Natural Sciences (NINS) - Japan; National Astronomical Observatory of Japan (NAOJ); Swinburne University of Technology; Tufts University; University of Wisconsin System; University of Wisconsin Madison; University of Melbourne; University of California System; University of California Riverside; University of California System; University of California Los Angeles; University of Arizona; University of Valencia; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad de Cantabria; CSIC - Instituto de Fisica de Cantabria (IFCA); University of Valencia; University of Massachusetts System; University of Massachusetts Amherst
  摘要：Recent James Webb Space Telescope (JWST) observations have revealed an unexpected abundance of massive-galaxy candidates in the early Universe, extending further in redshift and to lower luminosity than what had previously been found by submillimetre surveys1-6. These JWST candidates have been interpreted as challenging the Lambda cold dark-matter cosmology (where Lambda is the cosmological constant)7-9, but, so far, these studies have mostly relied on only rest-frame ultraviolet data and have...
• Observation of vortices in a dipolar supersolid AI翻译
  作者：Casotti, Eva; Poli, Elena; Klaus, Lauritz; Litvinov, Andrea; Ulm, Clemens; Politi, Claudia; Mark, Manfred J.; Bland, Thomas; Ferlaino, Francesca
  作者单位：Austrian Academy of Sciences; University of Innsbruck; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Supersolids are states of matter that spontaneously break two continuous symmetries: translational invariance owing to the appearance of a crystal structure and phase invariance owing to phase locking of single-particle wavefunctions, responsible for superfluid phenomena. Although originally predicted to be present in solid helium1-5, ultracold quantum gases provided a first platform to observe supersolids6-10, with particular success coming from dipolar atoms8-12. Phase locking in dipolar sup...
• A multicellular developmental program in a close animal relative AI翻译
  作者：Olivetta, Marine; Bhickta, Chandni; Chiaruttini, Nicolas; Burns, John; Dudin, Omaya
  作者单位：Swiss Institute Experimental Cancer Research; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Geneva; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Bigelow Laboratory for Ocean Sciences
  摘要：All animals develop from a single-celled zygote into a complex multicellular organism through a series of precisely orchestrated processes1,2. Despite the remarkable conservation of early embryogenesis across animals, the evolutionary origins of how and when this process first emerged remain elusive. Here, by combining time-resolved imaging and transcriptomic profiling, we show that single cells of the ichthyosporean Chromosphaera perkinsii-a close relative that diverged from animals about 1 b...
• Sticky situation: how adhesive bacteria drive colon cancer AI翻译
  作者：Ouyang, Kyanna S.; Puschhof, Jens
  作者单位：Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg
  摘要：Some bacteria can cause mutations associated with colon cancer. Insights about the surface adhesion proteins that enable these bacteria to bind to host cells point to how steps leading to tumour formation might be halted.
• Can AI review the scientific literature - and figure out what it all means? AI翻译
  作者：Pearson, Helen
  摘要：Artificial intelligence could help speedily summarize research. But it comes with risks.
• Worryingly high prevalence of retraction among top-cited researchers AI翻译
  作者：Xu, Shaoxiong Brian; Hu, Guangwei
  作者单位：Huanggang Normal University; Hong Kong Polytechnic University
• Probiotic neoantigen delivery vectors for precision cancer immunotherapy AI翻译
  作者：Redenti, Andrew; Im, Jongwon; Redenti, Benjamin; Li, Fangda; Rouanne, Mathieu; Sheng, Zeren; Sun, William; Gurbatri, Candice R.; Huang, Shunyu; Komaranchath, Meghna; Jang, Younguk; Hahn, Jaeseung; Ballister, Edward R.; Vincent, Rosa L.; Vardoshivilli, Ana; Danino, Tal; Arpaia, Nicholas
  作者单位：Columbia University; Columbia University; Columbia University; Columbia University
  摘要：Microbial systems have been synthetically engineered to deploy therapeutic payloads in vivo1,2. With emerging evidence that bacteria naturally home in on tumours3,4 and modulate antitumour immunity5,6, one promising application is the development of bacterial vectors as precision cancer vaccines2,7. Here we engineered probiotic Escherichia coli Nissle 1917 as an antitumour vaccination platform optimized for enhanced production and cytosolic delivery of neoepitope-containing peptide arrays, wit...
• CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors AI翻译
  作者：Skoulidis, Ferdinandos; Araujo, Haniel A.; Minh Truong Do; Qian, Yu; Sun, Xin; Cobo, Ana Galan; Le, John T.; Montesion, Meagan; Palmer, Rachael; Jahchan, Nadine; Juan, Joseph M.; Min, Chengyin; Yu, Yi; Pan, Xuewen; Arbour, Kathryn C.; Vokes, Natalie; Schmidt, Stephanie T.; Molkentine, David; Owen, Dwight H.; Memmott, Regan; Patil, Pradnya D.; Marmarelis, Melina E.; Awad, Mark M.; Murray, Joseph C.; Hellyer, Jessica A.; Gainor, Justin F.; Dimou, Anastasios; Bestvina, Christine M.; Shu, Catherine A.; Riess, Jonathan W.; Blakely, Collin M.; Pecot, Chad, V; Mezquita, Laura; Tabbo, Fabrizio; Scheffler, Matthias; Digumarthy, Subba; Mooradian, Meghan J.; Sacher, Adrian G.; Lau, Sally C. M.; Saltos, Andreas N.; Rotow, Julia; Johnson, Rocio Perez; Liu, Corinne; Stewart, Tyler; Goldberg, Sarah B.; Killam, Jonathan; Walther, Zenta; Schalper, Kurt; Davies, Kurtis D.; Woodcock, Mark G.; Anagnostou, Valsamo; Marrone, Kristen A.; Forde, Patrick M.; Ricciuti, Biagio; Venkatraman, Deepti; Van Allen, Eliezer M.; Cummings, Amy L.; Goldman, Jonathan W.; Shaish, Hiram; Kier, Melanie; Katz, Sharyn; Aggarwal, Charu; Ni, Ying; Azok, Joseph T.; Segal, Jeremy; Ritterhouse, Lauren; Neal, Joel W.; Lacroix, Ludovic; Elamin, Yasir Y.; Negrao, Marcelo, V; Le, Xiuning; Lam, Vincent K.; Lewis, Whitney E.; Kemp, Haley N.; Carter, Brett; Roth, Jack A.; Swisher, Stephen; Lee, Richard; Zhou, Teng; Poteete, Alissa; Kong, Yifan; Takehara, Tomohiro; Paula, Alvaro Guimaraes; Cuentas, Edwin R. Parra; Behrens, Carmen; Wistuba, Ignacio I.; Zhang, Jianjun; Blumenschein, George R.; Gay, Carl; Byers, Lauren A.; Gibbons, Don L.; Tsao, Anne; Lee, J. Jack; Bivona, Trever G.; Camidge, D. Ross; Gray, Jhannelle E.; Lieghl, Natasha; Levy, Benjamin; Brahmer, Julie R.; Garassino, Marina C.; Gandara, David R.; Garon, Edward B.; Rizvi, Naiyer A.; Scagliotti, Giorgio Vittorio; Wolf, Jurgen; Planchard, David; Besse, Benjamin; Herbst, Roy S.; Wakelee, Heather A.; Pennell, Nathan A.; Shaw, Alice T.; Janne, Pasi A.; Carbone, David P.; Hellmann, Matthew D.; Rudin, Charles M.; Albacker, Lee; Mann, Helen; Zhu, Zhou; Lai, Zhongwu; Stewart, Ross; Peters, Solange; Johnson, Melissa L.; Wong, Kwok K.; Huang, Alan; Winslow, Monte M.; Rosen, Michael J.; Winters, Ian P.; Papadimitrakopoulou, Vassiliki A.; Cascone, Tina; Jewsbury, Philip; Heymach, John, V
  作者单位：University of Texas System; UTMD Anderson Cancer Center; Foundation Medicine; Memorial Sloan Kettering Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University System of Ohio; Ohio State University; James Cancer Hospital & Solove Research Institute; Cleveland Clinic Foundation; University of Pennsylvania; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Johns Hopkins University; Johns Hopkins Medicine; Stanford University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Mayo Clinic; University of Chicago; Columbia University; University of California System; University of California Davis; University of California System; University of California San Francisco; University of North Carolina; University of North Carolina Chapel Hill; University of Barcelona; Hospital Clinic de Barcelona; University of Cologne; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; H Lee Moffitt Cancer Center & Research Institute; Memorial Sloan Kettering Cancer Center; University of California System; University of California San Diego; Yale University; Northwell Health; North Shore University Hospital; Yale University; University of Colorado System; University of Colorado Anschutz Medical Campus; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Icahn School of Medicine at Mount Sinai; University of Chicago; UNICANCER; Gustave Roussy; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado Denver; University of Turin; Novartis; Novartis USA; AstraZeneca; AstraZeneca; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); Tennessee Oncology; Sarah Cannon Research Institute; Pfizer; Pfizer USA
  摘要：For patients with advanced non-small-cell lung cancer (NSCLC), dual immune checkpoint blockade (ICB) with CTLA4 inhibitors and PD-1 or PD-L1 inhibitors (hereafter, PD-(L)1 inhibitors) is associated with higher rates of anti-tumour activity and immune-related toxicities, when compared with treatment with PD-(L)1 inhibitors alone. However, there are currently no validated biomarkers to identify which patients will benefit from dual ICB1,2. Here we show that patients with NSCLC who have mutations...
• Cretaceous bird from Brazil informs the evolution of the avian skull and brain AI翻译
  作者：Chiappe, Luis M.; Navalon, Guillermo; Martinelli, Agustin G.; Carvalho, Ismar de Souza; Miloni Santucci, Rodrigo; Wu, Yun-Hsin; Field, Daniel J.
  作者单位：University of Cambridge; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Museo Argentino de Ciencias Naturales Bernardino Rivadavia (MACN); Universidade Federal do Rio de Janeiro; Universidade de Coimbra; Universidade de Brasilia; University of Cambridge
  摘要：A dearth of Mesozoic-aged, three-dimensional fossils hinders understanding of the origin of the distinctive skull and brain of modern (crown) birds1. Here we report Navaornis hestiae gen. et sp. nov., an exquisitely preserved fossil species from the Late Cretaceous of Brazil. The skull of Navaornis is toothless and large-eyed, with a vaulted cranium closely resembling the condition in crown birds; however, phylogenetic analyses recover Navaornis in Enantiornithes, a highly diverse clade of Mes...