A multicellular developmental program in a close animal relative

• 成果类型: Article
• 署名作者: Olivetta, Marine; Bhickta, Chandni; Chiaruttini, Nicolas; Burns, John; Dudin, Omaya
• 署名单位: Swiss Institute Experimental Cancer Research; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Geneva; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Bigelow Laboratory for Ocean Sciences
• 刊物名称: Nature
• ISSN/ISSBN: 0028-4339
• DOI: 10.1038/s41586-024-08115-3
• 发表日期: 2024-11-14
• 关键词: differential expression analysis; asymmetric cell-division; symmetry-breaking; wengan biota; EVOLUTION; origin; mesomycetozoea; morphogenesis; sequence; embryos

摘要

All animals develop from a single-celled zygote into a complex multicellular organism through a series of precisely orchestrated processes1,2. Despite the remarkable conservation of early embryogenesis across animals, the evolutionary origins of how and when this process first emerged remain elusive. Here, by combining time-resolved imaging and transcriptomic profiling, we show that single cells of the ichthyosporean Chromosphaera perkinsii-a close relative that diverged from animals about 1 billion years ago3,4-undergo symmetry breaking and develop through cleavage divisions to produce a prolonged multicellular colony with distinct co-existing cell types. Our findings about the autonomous and palintomic developmental program of C. perkinsii hint that such multicellular development either is much older than previously thought or evolved convergently in ichthyosporeans. The ichthyosporean Chromosphaeraperkinsii develops via symmetry breaking and cleavage divisions, and it forms spatially organized colonies with distinct cell types.