Nature

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• Nuclear release of eIF1 restricts start-codon selection during mitosis AI翻译
  作者：Ly, Jimmy; Xiang, Kehui; Su, Kuan-Chung; Sissoko, Gunter B.; Bartel, David P.; Cheeseman, Iain M.
  作者单位：Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute
  摘要：Regulated start-codon selection has the potential to reshape the proteome through the differential production of upstream open reading frames, canonical proteins, and alternative translational isoforms1-3. However, conditions under which start codon selection is altered remain poorly defined. Here, using transcriptome-wide translation-initiation-site profiling4, we reveal a global increase in the stringency of start-codon selection during mammalian mitosis. Low-efficiency initiation sites are ...
• High CO2 dampens then amplifies N-induced diversity loss over 24 years AI翻译
  作者：Reich, Peter B.; Mohanbabu, Neha; Isbell, Forest; Hobbie, Sarah E.; Butler, Ethan E.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Michigan System; University of Michigan; Western Sydney University; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Rising levels of atmospheric carbon dioxide (CO2) and nitrogen (N) deposition affect plant communities in numerous ways(1-11). Nitrogen deposition causes local biodiversity loss globally(12-14), but whether, and if so how, rising CO2 concentrations amplify or dampen those losses remains unclear and is almost entirely unstudied. We addressed this knowledge gap with an open-air experiment in which 108 grassland plots were grown for 24 years under different CO2 and N regimes. We initially found t...
• The next massive volcano eruption will cause climate chaos - and we are unprepared AI翻译
  作者：Stoffel, Markus; Corona, Christophe; St George, Scott
  作者单位：University of Geneva; Centre National de la Recherche Scientifique (CNRS)
• Bioelastic state recovery for haptic sensory substitution AI翻译
  作者：Flavin, Matthew T.; Ha, Kyoung-Ho; Guo, Zengrong; Li, Shupeng; Kim, Jin-Tae; Saxena, Tara; Simatos, Dimitrios; Al-Najjar, Fatimah; Mao, Yuxuan; Bandapalli, Shishir; Fan, Chengye; Bai, Dongjun; Zhang, Zhuang; Zhang, Yanlin; Flavin, Eunhye; Madsen, Kenneth E.; Huang, Yi; Emu, Luoqian; Zhao, Jingyang; Yoo, Jae-Young; Park, Minsu; Shin, Jaeho; Huang, Aaron G.; Shin, Hee-Sup; Colgate, J. Edward; Huang, Yonggang; Xie, Zhaoqian; Jiang, Hanqing; Rogers, John A.
  作者单位：University System of Georgia; Georgia Institute of Technology; Northwestern University; Westlake University; Northwestern University; Pohang University of Science & Technology (POSTECH); Northwestern University; Shanghai Jiao Tong University; Dalian University of Technology; Dalian University of Technology; Dalian University of Technology; University System of Georgia; Georgia Institute of Technology; University of Illinois System; University of Illinois Urbana-Champaign; Sungkyunkwan University (SKKU); Dankook University; Korea Institute of Science & Technology (KIST); Northwestern University; Northwestern University; Westlake University; Westlake University; Northwestern University; Feinberg School of Medicine
  摘要：The rich set of mechanoreceptors found in human skin1,2 offers a versatile engineering interface for transmitting information and eliciting perceptions3,4, potentially serving a broad range of applications in patient care5 and other important industries6,7. Targeted multisensory engagement of these afferent units, however, faces persistent challenges, especially for wearable, programmable systems that need to operate adaptively across the body8-11. Here we present a miniaturized electromechani...
• Space weather mapped by millions of smartphones AI翻译
  作者：Vierinen, Juha
  作者单位：UiT The Arctic University of Tromso
• For sale: baby shoes, worn way too often AI翻译
  作者：Pettit, M. J.
• 'A big, big win': plan to pay for wildlife conservation emerges at biodiversity summit AI翻译
  作者：Taylor, Luke
• 'We need to be ready for a new world': scientists globally react to Trump election win AI翻译
  作者：Tollefson, Jeff
• China's thriving forests are stockpiling vast amounts of carbon AI翻译
  作者：[Anonymous]
• Calcium-permeable AMPA receptors govern PV neuron feature selectivity AI翻译
  作者：Hong, Ingie; Kim, Juhyun; Hainmueller, Thomas; Kim, Dong Won; Keijser, Joram; Johnson, Richard C.; Park, Soo Hyun; Limjunyawong, Nathachit; Yang, Zhuonan; Cheon, David; Hwang, Taeyoung; Agarwal, Amit; Cholvin, Thibault; Krienen, Fenna M.; McCarroll, Steven A.; Dong, Xinzhong; Leopold, David A.; Blackshaw, Seth; Sprekeler, Henning; Bergles, Dwight E.; Bartos, Marlene; Brown, Solange P.; Huganir, Richard L.
  作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Korea Brain Research Institute (KBRI); University of Freiburg; Technical University of Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); Korea Advanced Institute of Science & Technology (KAIST); Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Ruprecht Karls University Heidelberg; Princeton University; Harvard University; Harvard Medical School; Johns Hopkins University; Howard Hughes Medical Institute; Johns Hopkins University; Johns Hopkins University; NYU Langone Medical Center; New York University; Aarhus University; Aarhus University; Mahidol University
  摘要：The brain helps us survive by forming internal representations of the external world(1,2). Excitatory cortical neurons are often precisely tuned to specific external stimuli(3,4). However, inhibitory neurons, such as parvalbumin-positive (PV) interneurons, are generally less selective5. PV interneurons differ from excitatory neurons in their neurotransmitter receptor subtypes, including AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors (AMPARs)(6,7). Excitatory neurons exp...