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作者：Grosskopf, Johannes; Gopatta, Chawanansaya; Martin, Robert T.; Haseloer, Alexander; Macmillan, David W. C.
作者单位：Princeton University
摘要：The efficient and modular diversification of molecular scaffolds, particularly for the synthesis of diverse molecular libraries, remains a notable challenge in drug optimization campaigns1, 2-3. The late-stage introduction of alkyl fragments is especially desirable due to the high sp3 character and structural versatility of these motifs4. Given their prevalence in molecular frameworks, C(sp2)-H bonds serve as attractive targets for diversification, although this process often requires difficul...
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作者：Ambrose, Kristal K.; Walker, Tony R.
作者单位：Dalhousie University
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作者：Scerri, Eleanor M. L.; Blinkhorn, James; Groucutt, Huw S.; Stewart, Mathew; Candy, Ian; Allue, Ethel; Burguet-Coca, Aitor; Curras, Andres; Carleton, W. Christopher; Lindauer, Susanne; Spengler, Robert; Boxleitner, Kseniia; Asciak, Gillian; Colucci, Margherita; Gauci, Ritienne; Hatton, Amy; Kutowsky, Johanna; Maier, Andreas; Mata-Gonzalez, Mario; Mifsud, Nicolette; Niang, Khady; Roberts, Patrick; de Giorgio, Joshua; Xerri, Rochelle; Vella, Nicholas C.
作者单位：Max Planck Society; University of Malta; University of Cologne; University of Liverpool; Griffith University; University of London; Royal Holloway University London; Universitat Rovira i Virgili; Leiden University - Excl LUMC; Leiden University; Max Planck Society; Max Planck Society; University of Cambridge; University of Malta; Max Planck Society; Eberhard Karls University of Tubingen; University Cheikh Anta Diop Dakar; Max Planck Society; University of York - UK
摘要：The Maltese archipelago is a small island chain that is among the most remote in the Mediterranean. Humans were not thought to have reached and inhabited such small and isolated islands until the regional shift to Neolithic lifeways, around 7.5 thousand years ago (ka)1. In the standard view, the limited resources and ecological vulnerabilities of small islands, coupled with the technological challenges of long-distance seafaring, meant that hunter-gatherers were either unable or unwilling to m...
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作者：Liang, Jiaming; Shi, Junhui; Song, Ailong; Lu, Meihua; Zhang, Kairan; Xu, Meng; Huang, Gaoxingyu; Lu, Peilong; Wu, Xudong; Ma, Dan
作者单位：Fudan University; Westlake University; Westlake Laboratory; Westlake University
摘要：The mitochondrial pyruvate carrier (MPC) is a mitochondrial inner membrane protein complex that is essential for the uptake of pyruvate into the mitochondrial matrix as the primary carbon source for the tricarboxylic acid cycle1,2. Here we present six cryo-electron microscopy structures of human MPC in three states: three structures in the intermembrane space (IMS)-open state, obtained in different conditions; a structure of pyruvate-treated MPC in the occluded state; and two structures in the...
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作者：[Anonymous]
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作者：Zhao, Ping; Shekhawat, Vijay; Girardi, Marcello; He, Zonglong; Torres-Company, Victor; Andrekson, Peter A.
作者单位：Chalmers University of Technology; Sichuan University
摘要：Four-wave mixing is a nonlinear optical phenomenon that can be used for wideband low-noise optical amplification and wavelength conversion. It has been extensively investigated for applications in communications1, computing2, metrology3, imaging4 and quantum optics5. With its advantages of small footprint, large nonlinearity and dispersion-engineering capability, optical integrated waveguides are excellent candidates for realizing high-gain and large-bandwidth four-wave mixing for which anomal...
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作者：Kozlov, Max; Ryan, Chris
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作者：Rubartelli, Anna; Poli, Valeria; Mattaj, Iain; Sitia, Roberto
作者单位：University of Genoa; IRCCS AOU San Martino IST; University of Turin; Human Technopole; Vita-Salute San Raffaele University
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作者：Yuan, Sujing; Sun, Renqiang; Shi, Hao; Chapman, Nicole M.; Hu, Haoran; Guy, Cliff; Rankin, Sherri; Kc, Anil; Palacios, Gustavo; Meng, Xiaoxi; Sun, Xiang; Zhou, Peipei; Yang, Xiaoyang; Gottschalk, Stephen; Chi, Hongbo
作者单位：St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital
摘要：Tumour cells often evade immune pressure exerted by CD8+ T cells or immunotherapies through mechanisms that are largely unclear1,2. Here, using complementary in vivo and in vitro CRISPR-Cas9 genetic screens to target metabolic factors, we established voltage-dependent anion channel 2 (VDAC2) as an immune signal-dependent checkpoint that curtails interferon-gamma (IFN gamma)-mediated tumour destruction and inflammatory reprogramming of the tumour microenvironment. Targeting VDAC2 in tumour cell...
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作者：Bibi, Faysal
作者单位：Leibniz Institut fur Evolutions und Biodiversitatsforschung
