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作者:VanderWeele, Tyler J.; Johnson, Byron R.
作者单位:Harvard University; Harvard University; Baylor University; Baylor University
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作者:[Anonymous]
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作者:Robinson, Andrew
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作者:Shahid, Taha; Danazumi, Ammar U.; Tehseen, Muhammad; Alhudhali, Lubna; Clark, Alice R.; Savva, Christos G.; Hamdan, Samir M.; De Biasio, Alfredo
作者单位:King Abdullah University of Science & Technology; University of Leicester; University of Leicester
摘要:Hexameric helicases are nucleotide-driven molecular machines that unwind DNA to initiate replication across all domains of life. Despite decades of intensive study, several critical aspects of their function remain unresolved1: the site and mechanism of DNA strand separation, the mechanics of unwinding propagation, and the dynamic relationship between nucleotide hydrolysis and DNA movement. Here, using cryo-electron microscopy (cryo-EM), we show that the simian virus 40 large tumour antigen (L...
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作者:Inacio, Ana R.; Lam, Ka Chun; Zhao, Yuan; Pereira, Francisco; Gerfen, Charles R.; Lee, Soohyun
作者单位:National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
摘要:Revealing the connectivity of functionally identified individual neurons is necessary to understand how activity patterns emerge and support behaviour. Yet the brain-wide presynaptic wiring rules that lay the foundation for the functional selectivity of individual neurons remain largely unexplored. Cortical neurons, even in primary sensory cortex, are heterogeneous in their selectivity, not only to sensory stimuli but also to multiple aspects of behaviour. Here, to investigate presynaptic conn...
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作者:Gibney, Elizabeth
摘要:The 'off-the-charts saturated' greenish hue - called olo - has been seen by only five study participants.
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作者:Musgrave, Rebecca
作者单位:University of London; King's College London
摘要:A new class of organometallic compound has been made that has a distinctive geometry and electronic structure - with potential for catalysis and materials science.
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作者:Ribeiro Junior, Howard Lopes
作者单位:Universidade Federal do Ceara
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作者:Yuan, Tao; Zhong, Shijie
作者单位:University of Colorado System; University of Colorado Boulder
摘要:Glacial cycles significantly influenced Earth's surface processes throughout the Quaternary, impacting the climate, sea level, and seismic and magmatic activity1, 2-3. However, the effects of glaciation and deglaciation (that is, glacial forcing) on lithospheric motion are unknown. To study these effects, we formulated high-resolution numerical models with realistic lithospheric structures, including weak plate margins, lithospheric thickness variations and crustal structure. Our results show ...
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作者:Kazakov, Dmitry; Letsou, Theodore P.; Piccardo, Marco; Columbo, Lorenzo L.; Brambilla, Massimo; Prati, Franco; Dal Cin, Sandro; Beiser, Maximilian; Opacak, Nikola; Ratra, Pawan; Pushkarsky, Michael; Caffey, David; Day, Timothy; Lugiato, Luigi A.; Schwarz, Benedikt; Capasso, Federico
作者单位:Harvard University; Massachusetts Institute of Technology (MIT); Universidade de Lisboa; Polytechnic University of Turin; Politecnico di Bari; University of Insubria; Technische Universitat Wien; Imperial College London; Interuniversity Microelectronics Centre
摘要:Despite the continuing progress in integrated optical frequency comb technology1, compact sources of short, bright pulses in the mid-infrared wavelength range from 3 to 12 mu m so far remain beyond reach. The state-of-the-art ultrafast pulse emitters in the mid-infrared are complex, bulky and inefficient systems based on the downconversion of near-infrared or visible pulsed laser sources. Here we show a purely DC-driven semiconductor laser chip that generates 1-ps solitons at the centre wavele...