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作者：Srinivasan, Ramesh
作者单位：University of California System; University of California Los Angeles
摘要：Silicon Valley's billionaires have become ideological provocateurs, spreading rage and reshaping the public sphere.
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作者：Xu, Zheng; Wang, Hongshuang; Yu, Jingjing; Deng, Yue; Tian, Xiaowen; Ni, Rongjun; Xia, Fan; Yang, Lingyi; Xu, Chanjuan; Zhang, Liting; Luo, Renxuan; Chen, Peipei; Zhang, Xiaoyu; Liu, Yuxuan; Hou, Jingyu; Zhang, Miyuan; Chen, Shasha; Su, Lantian; Sun, Hui; He, Yixiao; Chen, Dandan; Chen, Xiaoting; Miao, Zhuang; Xie, Jie; Liu, Xinlei; Zhao, Jie; Ke, Bowen; Tian, Xiaohe; Zeng, Linan; Zhang, Lingli; Tang, Xiangdong; Yang, Shengyong; Liu, Jianfeng; Wang, Xiaohui; Yan, Wei; Shao, Zhenhua
作者单位：Sichuan University; Sichuan University; Tianfu Jincheng Laboratory; Sichuan University; Chinese Academy of Sciences; Changchun Institute of Applied Chemistry, CAS; Sichuan University; Sichuan University; Sichuan University; Huazhong University of Science & Technology; Bioland Lab; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Sichuan University; Sichuan University; Sichuan University; Sichuan Normal University; Sichuan University; Sichuan University; Zhejiang University
摘要：Psychedelics are undergoing a renaissance as potential therapy for psychiatric disorders, with more than 200 clinical trials being studied across several countries1, 2-3. However, the precise mechanisms by which these drugs bring about benefits and the potential clinical risks are not yet fully understood. The serotonin 2A receptor (5-HT2AR) was reported to be a Gq-coupled receptor and the primary interoceptive target of psychedelics4,5. Here we compared psychedelics and their non-hallucinogen...
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作者：Zeng, Han; Liu, Qi; Zhao, Fangchen; Luo, Cui; Wang, Dezhi; Zhu, Yuyan; Liu, Yao; Chen, Kai; Sun, Zhixin; Hong, Yanjie; Miao, Lanyun; Hu, Chunlin; Sun, Haijing; Pan, Bing; Zhao, Jialin; Yin, Zongjun; Li, Guoxiang; Yang, Xinglian; Yang, Aihua; Hu, Shixue; Zhu, Maoyan
作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Guizhou University; Linyi University; Nanjing University; China Geological Survey; Chengdu Center, China Geological Survey
摘要：Cambrian Burgess Shale-type (BST) fossil biotas document nearly complete snapshots of the oldest Phanerozoic marine ecosystems1, 2, 3-4. However, the rarity of deposits bearing high-diversity BST biotas5 has restricted our understanding of the evolutionary and ecological dynamics of the Cambrian explosion. Here we report the Huayuan biota-a lower Cambrian (Stage 4, approximately 512 million years ago) BST Lagerst & auml;tte from an outer shelf, deep-water setting of the Yangtze Block in Hunan,...
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作者：Ding, Jingwen W.; Kim, Chang N.; Ostrowski, Megan S.; Abeykoon, Yashodara; Pavlovic, Bryan J.; Wallace, Jenelle L.; Schaefer, Nathan K.; Nowakowski, Tomasz J.; Pollen, Alex A.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：Human cortical neurogenesis involves conserved and specialized developmental processes during a restricted window of prenatal development. Radial glia (RG) neural stem cells shape cortical cell diversity by giving rise to excitatory neurons, oligodendrocytes and astrocytes, as well as olfactory bulb interneurons (INs) and a recently characterized population of cortical INs1,2. Complex genetic programs orchestrated by transcription factor (TF) circuits govern the balance between self-renewal an...
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作者：Ringer, Talia
作者单位：University of Illinois System; University of Illinois Urbana-Champaign
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作者：Bhat, Mohan
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作者：Zhang, Siwei; Yuan, Weijun; Bigagli, Niccolo; Kwak, Haneul; Karman, Tijs; Stevenson, Ian; Will, Sebastian
作者单位：Columbia University; Radboud University Nijmegen
摘要：Ultracold gases of dipolar molecules have long been envisioned as a platform for the realization of novel quantum phases1, 2, 3, 4, 5, 6, 7-8. Recent advances in collisional shielding9, 10, 11-12, protecting molecules from inelastic losses, have enabled the creation of degenerate Fermi gases13, 14-15 and, more recently, Bose-Einstein condensation of dipolar molecules16. However, the observation of quantum phases in ultracold molecular gases that are driven by dipole-dipole interactions has so ...
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作者：Lai, Shoulong; Yang, Xigui; Shi, Jiuyang; Liu, Shijie; Guo, Ying; Yan, Longbin; Zang, Jinhao; Zhang, Zhuangfei; Jia, Qiuhan; Sun, Jian; Cheng, Shaobo; Shan, Chongxin
作者单位：Zhengzhou University; Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Henan University of Science & Technology; Henan University of Science & Technology
摘要：Known as the 'ultimate semiconductor', cubic diamond (CD) has gained substantial interest both scientifically and industrially. Its polymorph, hexagonal diamond (HD), is even more intriguing because of its fascinating properties associated with the meteorite impacts1, 2, 3, 4, 5, 6, 7-8. As no solid experimental evidence has been provided to prove its existence, the physical properties of HD remain largely unexplored. Here we report the synthesis of millimetre-sized, phase-pure HD from highly ...
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作者：Zabala-Letona, Amaia; Pujana-Vaquerizo, Mikel; Martinez-Laosa, Belen; Ponce-Rodriguez, Maria; Garcia-Longarte, Saioa; Mendizabal, Isabel; Gimeno, Ana; Rogalska, Malgorzata; Tan, Joycelyn; Cabrera, Diana; Van Liempd, Sebastiaan; Ximenez-Embun, Pilar; Espinosa, Sergio; Fagoaga-Eugui, Maider; Peccati, Francesca; Zakrzewski, Maciej; Astobiza, Ianire; Arana-Castanares, Mikel; Cherkaoui, Sarah; Sendino, Maria; Martin-Barros, Ines; Ercilla, Amaia; Bozal-Basterra, Laura; Carlevaris, Onintza; Arruabarrena-Aristorena, Amaia; Perez-Andres, Encarnacion; Santamaria-Zamorano, Telmo; Ferrer-Bonsoms, Juan A.; Carazo, Fernando; Ciesla, Maciej; Lobato, Cesar; Seoane, Joan; Martin-Martin, Natalia; Barrio, Rosa; Sutherland, James D.; Aransay, Ana M.; Falcon-Perez, Juan Manuel; Martinez-Pastor, Barbara; Rubio, Angel; Blanco, Francisco J.; Hogarty, Michael D.; Morscher, Raphael J.; Berra, Edurne; Serwa, Remigiusz A.; Jimenez-Barbero, Jesus; Jimenez-Oses, Gonzalo; Efeyan, Alejo; Finley, Lydia; Lizcano, Jose M.; Munoz, Javier; Valcarcel, Juan; Carracedo, Arkaitz
作者单位：CIC bioGUNE; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; Basque Foundation for Science; Pompeu Fabra University; Barcelona Institute of Science & Technology; Centre de Regulacio Genomica (CRG); Memorial Sloan Kettering Cancer Center; Centro Nacional de Investigaciones Oncologicas (CNIO); Hospital Universitari Vall d'Hebron; Autonomous University of Barcelona; Hospital Universitari Vall d'Hebron; Autonomous University of Barcelona; Vall d'Hebron Institut de Recerca (VHIR); Vall d'Hebron Institut d'Oncologia (VHIO); International Institute of Molecular Mechanisms & Machines Polish Academy of Sciences; University of Zurich; University Children's Hospital Zurich; University of Zurich; University of Basque Country; University of Navarra; University of Navarra; ICREA; Autonomous University of Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Centro Nacional de Investigaciones Oncologicas (CNIO); Prince Felipe Research Center; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Pompeu Fabra University; University of Basque Country
摘要：Metabolites are central to cellular homeostasis. Although much emphasis has been placed on their relevance to meet energetic and biosynthetic demands, metabolic intermediates also function as signalling molecules. Here we show that polyamines, small polycations that are critical to cellular homeostasis1, 2-3, regulate the process of alternative pre-mRNA splicing. We find that inhibition of polyamine synthesis increases phosphorylation of spliceosomal proteins, concomitant with perturbation of ...
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作者：Weiner, Kevin S.; Torres, Mauro; Willbrand, Ethan H.
作者单位：University of California System; University of California Berkeley; University of Wisconsin System; University of Wisconsin Madison
