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作者：Mei, Zepeng; Lin, Shuheng; Fang, Keyan; Tang, Wanru; Zhou, Feifei; Liu, Fei; Zhao, Sen; Wu, Hao; Li, Jinbao; Zhao, Zheng; Ou, Tinghai; Xie, Xiaoxun; Chen, Deliang; Nobre, Carlos
作者单位：Fujian Normal University; Sun Yat Sen University; Southern Marine Science & Engineering Guangdong Laboratory; Sun Yat Sen University; Southern Marine Science & Engineering Guangdong Laboratory (Zhuhai); University of Hawaii System; University of Hawaii Manoa; East China University of Technology; University of Hong Kong; University of Gothenburg; Chinese Academy of Sciences; Institute of Earth Environment, CAS; Tsinghua University
摘要：The El Ni & ntilde;o-Southern Oscillation (ENSO) exhibits its weakest predictability during boreal spring, a phenomenon known as the Spring Predictability Barrier (SPB). The SPB arises from weak air-sea coupling that limits the growth and persistence of the ENSO signal. Improving springtime prediction therefore requires identifying oceanic regions most relevant for convection variability. Here, we introduce a Sea Surface Temperature Range Index (SRI), which quantifies the spatial extent of Sea...
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作者：Fu, Feng; Chen, Xingru; Christakis, Nicholas A.
作者单位：Dartmouth College; Dartmouth College; Yale University; Beihang University; Yale University; Yale University
摘要：Sociotechnical networks, in which humans and technologies act as interacting entities (also known as hybrid systems), increasingly face perturbations by automated agents. What this implies for immersive steering of collective behavior, and how this shapes the stability and resilience of cooperation, remain unclear. Here, we extend evolutionary graph theory by incorporating a distinct type of node representing embedded intelligent agents, namely, algorithmic nodes that autonomously implement pr...
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作者：Kiermer, Veronique; Adams, Sofia; Domingo, Kirsten Bibbins-; Bueso, Yensi Flores; Jamieson, Kathleen Hall; Heber, Joerg; Hosseini, Mohammad; Marusic, Ana; Nielsen, Beau; Skipper, Magdalena; Swamy, Geeta K.; Wolf, Susan M.
作者单位：University of Pennsylvania; American Medical Association; University College Cork; University of Washington; University of Washington Seattle; University of Pennsylvania; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Northwestern University; Feinberg School of Medicine; University of Split; University of Split; National Academies of Sciences, Engineering & Medicine; Duke University; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
摘要：Authorship remains the primary currency of academic credit and a cornerstone of research integrity, yet current practices often fail to reflect the collaborative and interdisci-plinary nature of modern science and questionable authorship practices persist. We argue that addressing these short-comings is a collective responsibility shared by researchers, journals, research funders, scholarly societies, and research institutions. We examined authorship guidelines issued journals and research ins...
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作者：Blumstein, Daniel T.
作者单位：University of California System; University of California Los Angeles
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作者：Hauer, Lukas; Sporbeck, Katharina; Mckenna, Joseph F.; Puchkov, Dmytro; May, Alexander I.; Frigerio, Lorenzo; Knorr, Roland L.; Bahrami, Amir H.
作者单位：University of Cologne; Humboldt University of Berlin; University of Warwick; Leibniz Association; Leibniz Forschungsinstitut furr Molekulare Pharmakologie (FMP); Institute of Science Tokyo; University of Tokyo; University of Tokyo; Ihsan Dogramaci Bilkent University
摘要：Phase-separated biomolecular condensates with liquid-like properties play a key role in the organization and compartmentalization of the intracellular environment. Condensate-mediated capillary forces acting on membranes drive physiologically important reshaping of membrane-bound organelles, such as vacuoles and autophagosomes. Here, we explore condensate-mediated membrane shape transformations. We employ in planta live-cell imaging, an in vitro reconstitution system with tunable interfacial t...
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作者：Qu, Guangyin; Guo, Lulu; Zhang, Xiaojuan; Li, Siqi; Kuai, Yan; Fu, Weiwei; Yang, Tianyu; Wen, Jialin; Yu, Benli; Hu, Zhijia
作者单位：Anhui University; Peking University; Anhui University; Hefei University of Technology; Chinese Academy of Sciences
摘要：Structural colors hold significant application value in anticounterfeiting, displays, and smart coatings due to their high stability, eco-friendliness, and dynamic optical response potential. However, conventional fabrication strategies for photonic crystals-such as photolithography and inkjet printing-suffer from limitations including high mask costs, nozzle clogging, lattice defects, and difficulties in scaling production. This study introduces an innovative screen-printing technique to achi...
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作者：Song, Qiuyue; Peng, Lisi; Yang, Xiaoli; Xu, Jiaheng; Zhang, Deyu; Tian, Xiaorong; Li, Shiyu; Zhang, Yang; Ji, Baoan; Jin, Zhendong; Ding, Zhanyu; Li, Zhaoshen; Huang, Haojie
作者单位：Naval Medical University; Mayo Clinic
摘要：Elucidating the structure and function of enteropeptidase (EP) is essential for advancing our understanding of its biological significance, particularly in regulating trypsinogen activation. Using cryo-EM and enzymatic activity, we uncovered the significance of the CUB2 domain in mediating the cleavage of macromolecular substrates. We identified crucial binding loops and key residues for EP's proteolytic function. The mutation E574A enhanced the proteolytic activity of EP, whereas the mutation...
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作者：Wang, Ruijie; Cao, Leixi; He, Xianwei; Thorne, Rick Francis; Wu, Qichen; Ding, Caoyuan; Zhang, Jinjing; Li, Mengfan; Shi, Zeyuan; Dong, Xinyi; Li, Jing; Li, Hongxiang; Gao, Suhua; Li, Jinming; Zhang, Xu Dong; Jin, Lei; Fan, Tianli; Wu, Mian
作者单位：Zhengzhou University; Henan University; Zhengzhou University; Zhengzhou University; Zhejiang University; University of Newcastle
摘要：Glutamine metabolism is essential for tumor cell proliferation and biosynthesis. However, solid tumors often face chronic glutamine deprivation, and the underlying adaptive mechanisms remain incompletely understood. Here, we show that glutamine scarcity upregulates choline kinase alpha (CHKA), whose monomerization enhances its noncanonical protein kinase activity. CHKA phosphorylates promyelocytic leukemia (PML) at tyrosine 339, promoting its cytoplasmic localization. Notably, this reflects a ...
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作者：Dong, Yun; Ji, Xianglin; Dong, Tao; Wang, Yun; Bakkeren, Erik; Foster, Kevin R.; Huang, Wei E.
作者单位：University of Oxford; University of Oxford; Southern University of Science & Technology; University of Oxford; University of Calgary
摘要：Antimicrobial resistance (AMR) is a critical global health challenge. In this study, we developed a platform based on chromosome- free and nonreplicating simple cells (SimCells, size 1 to 2 & micro;m) and mini- SimCells (size 100 to 400 nm) for targeted pathogen elimination. Engineered with surface- displayed nanobodies, SimCells and mini- SimCells selectively bind bacteria expressing specific antigens (e.g., OmpA in Escherichia coli). The selective interactions facilitate close SimCell- patho...
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作者：van Haastert, Peter J. M.
作者单位：University of Groningen
