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作者：Aoyama, Junya; Liu, Ren; Zhang, Xinhe; Zhu, Anthony Y.; Luanpaisanon, Pichayathida; Velayutham, Nivedhitha; Garbern, Jessica C.; Cao, Fang; Barrera, Irving; Fandl, Hannah; Sokol, Morgan; Dasariraju, Satvik; Gil, Eun Seok; Aleksi, Elton; Amanuma, Toshi; Saucerman, Jeffrey J.; Chen, Fei; Liu, Jia; Lee, Richard T.
作者单位：Harvard University; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Virginia (UVA) Health System; University of Virginia; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
摘要：The transplantation of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offers a potential treatment for heart failure, but arrhythmogenic automaticity can arise from these transplanted cells. In this study, we investigated the effects of RADA16, a clinically approved self-assembling peptide that forms nanofibers after injection, on the vascularization, myofibril structure, and electrophysiological adaptation of hiPSC-CMs transplanted into rat hearts. RADA16 accelerated t...
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作者：Vetere, Gisella
作者单位：Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI)
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作者：Wei, Yaqiang
作者单位：Shanghai University
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作者：Xie, Bowen; Yuan, Bowen; Zhao, Xiaohong; Xie, Tian; Li, Ruifeng; Wei, Peng; Sun, Qinli; Hu, Wenbo; Pan, Birui; Chen, Yongzhen; Wei, Kun; Zhao, Zixuan; Yuan, Lei; Zhong, Xuan; Bai, Xue; Lan, Qiuyan; Qin, Lei; Ni, Ling; Dong, Chen
作者单位：Westlake University; Tsinghua University; Tsinghua University; Tsinghua University; Central South University
摘要：Conventional type 1 dendritic cells (cDC1s) capture antigens in peripheral tissues and migrate to draining lymph nodes (dLNs) to prime antigen-specific CD8+ T cells. How tumor antigens are processed to activate CD8+ T cell immunity is not well understood. In this work, we show that Ms4a7 is up-regulated in cDC1s after tumor antigen uptake or exposure to exogenous stimuli and is required for their cross-priming ability. Although Ms4a7-/- mice showed normal cDC1 development and turnover, they fa...
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作者：Burgasser, Adam J.; Gonzales, Eileen C.; Beiler, Samuel A.; Visscher, Channon; Burningham, Ben; Mace, Gregory N.; Faherty, Jacqueline K.; Zhang, Zenghua; Sousa-Silva, Clara; Lodieu, Nicolas; Metchev, Stanimir A.; Meisner, Aaron; Cushing, Michael; Schneider, Adam C.; Suarez, Genaro; Hsu, Chih-Chun; Gerasimov, Roman; Aganze, Christian; Theissen, Christopher A.
作者单位：University of California System; University of California San Diego; California State University System; San Francisco State University; University System of Ohio; University of Toledo; University of Hertfordshire; University of Texas System; University of Texas Austin; American Museum of Natural History (AMNH); Nanjing University; Nanjing University; Universidade do Porto; Instituto de Astrofisica de Canarias; Universidad de la Laguna; Instituto de Astrofisica de Canarias; Western University (University of Western Ontario); Western University (University of Western Ontario); National Science Foundation (NSF); Northwestern University; University of Notre Dame; Stanford University
摘要：The atmospheres of low-temperature brown dwarfs and gas giant planets are expected to contain the phosphine molecule, PH3. However, previous observations have shown much lower abundances of this molecule than predicted with atmospheric chemistry models. We report JWST spectroscopic observations of phosphine in the atmosphere of the brown dwarf Wolf 1130C. Multiple absorption lines due to phosphine have been detected around 4.3 micrometers, from which we calculated a phosphine abundance of 0.10...
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作者：Gelsinger, Diego Rivera; Ronda, Carlotta; Ma, Junjie; Kar, Om B.; Edwards, Madeline; Huang, Yiming; Mavros, Chrystal F.; Sun, Yiwei; Perdue, Tyler; Vo, Phuc Leo; Ivanov, Ivaylo I.; Sternberg, Samuel H.; Wang, Harris H.
作者单位：Columbia University; Columbia University; Columbia University; Columbia University; Columbia University; Columbia University; Howard Hughes Medical Institute; Columbia University; University of California System; University of California Berkeley; Vertex Pharmaceuticals
摘要：Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce Metagenomic Editing (MetaEdit) as a platform technology for microbiome engineering that uses optimized CRISPR-associated transposases delivered by a broadly conjugative vector to directly modify diverse native commensal bacteria from mice and humans with new pathways at single-nucleotide genomic r...
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作者：Zhu, Haocheng; Qin, Xu; Wei, Leyan; Jiang, Dandan; Zhang, Qiao; Wang, Wenqian; Liang, Ronghong; Zhang, Rui; Zhang, Kang; Liu, Guanwen; Zhao, Kevin Tianmeng; Chen, Kunling; Qiu, Jin-Long; Gao, Caixia
作者单位：Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Microbiology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Directed evolution can rapidly generate genetic variants with new and enhanced properties, yet efficient platforms for performing such evolution directly in plant cells have been lacking. We developed geminivirus replicon-assisted in planta directed evolution (GRAPE), a system that links gene function to geminivirus rolling circle replication to enable high-throughput selection for desired activities. GRAPE supports the screening of up to 105 variants on a single Nicotiana benthamiana leaf wit...
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作者：Mulhair, Peter O.; Redmond, Anthony K.
作者单位：University of Liverpool; University College Dublin
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作者：Zhao, Chang-Xin; Wang, Zeyi; Jacobson, David; Li, Yue; Khaykovich, Boris; Fayfar, Sean; Zheng, Lei; Lamanna, Jacob; Chen, Xilin; Hussey, Daniel S.; Chen, Fu; Veith, Gabriel M.; Wang, Chunsheng
作者单位：University System of Maryland; University of Maryland College Park; National Institute of Standards & Technology (NIST) - USA; University System of Maryland; University of Maryland College Park; Massachusetts Institute of Technology (MIT); United States Department of Energy (DOE); Oak Ridge National Laboratory
摘要：Fast charging (at rates greater than 4 C) is essential for high-energy lithium-ion batteries in electric vehicles yet remains challenging owing to a lack of understanding of fast-charging barriers. Conventional optimization strategies concentrate on shortening lithium-ion transport pathways through electrode structure modification, which often compromises energy densities. In this work, we demonstrate that thick-electrode fast charging is constrained by solvent withdrawal within porous electro...
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作者：Cohen, Jon
