6774期

最新文章

• Australia's toxic algal bloom has a surprise culprit AI翻译
  作者：Stokstad, Erik
• Nucleotides on the frontline: Nucleotide-centric defense systems reveal a core principle in bacterial antiviral immunity AI翻译
  作者：Tal, Nitzan
  作者单位：Weizmann Institute of Science
• Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2 AI翻译
  作者：Klebba, Joseph E.; Roy, Nilotpal; Bernard, Steffen M.; Grabow, Stephanie; Hoffman, Melissa A.; Miao, Hui; Tamiya, Junko; Wang, Jinwei; Berry, Cynthia; Esparza-Oros, Antonio; Lin, Richard; Liu, Yongsheng; Pariollaud, Marie; Parker, Holly; Mochalkin, Igor; Rana, Sareena; Snead, Aaron N.; Walton, Eric J.; Wyrick, Taylor E.; Aitichson, Erick; Bedke, Karl; Brannon, Jacyln C.; Chick, Joel M.; Hee, Kenneth; Horning, Benjamin D.; Ismail, Mohamed; Lamb, Kelsey N.; Lin, Wei; Lu, Justine; Pastuszka, Martha K.; Pollock, Jonathan; Sigler, John J.; Tomaschko, Mona; Tran, Eileen; Yue, Chanyu; Kinsella, Todd M.; Molina-Arcas, Miriam; Cook, Brian N.; Simon, Gabriel M.; Weinstein, David S.; Downward, Julian; Patricelli, Matthew P.
  作者单位：Francis Crick Institute; Novartis; Novartis USA
  摘要：Genetic disruption of the RAS binding domain (RBD) of phosphoinositide 3-kinase alpha (PI3K alpha) impairs the growth of tumors driven by the small guanosine triphosphatase RAS in mice and does not affect PI3K alpha's role in insulin-mediated control of glucose homeostasis. Selectively blocking the RAS-PI3K alpha interaction may represent a strategy for treating RAS-dependent cancers as it avoids the toxicity associated with inhibitors of PI3K alpha lipid kinase activity. We developed compound...
• Transposable elements are vectors of recurrent transgenerational epigenetic inheritance AI翻译
  作者：Baduel, Pierre; De Oliveira, Louna; Caillieux, Erwann; Bohl-Viallefond, Gregoire; Xu, Ciana; El Messaoudi, Mounia; Petit, Aurelien; Drai, Maeva; Barois, Matteo; Singh, Vipin; Sarazin, Alexis; Teixeira, Felipe K.; Boccara, Martine; Gilbault, Elodie; de France, Antoine; Quadrana, Leandro; Loudet, Olivier; Colot, Vincent
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure (ENS); CNRS - National Institute for Biology (INSB); Universite Paris Saclay; INRAE; AgroParisTech; Austrian Academy of Sciences; Vienna Biocenter (VBC); Gregor Mendel Institute of Molecular Plant Biology (GMI); Centre National de la Recherche Scientifique (CNRS); Universite de Lille; CNRS - Institute of Ecology & Environment (INEE); Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Cambridge; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Universite PSL; Museum National d'Histoire Naturelle (MNHN); Ecole Pratique des Hautes Etudes (EPHE); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite
  摘要：DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and importance of this additional system of inheritance are unknown. In this work, we demonstrate in Arabidopsis thaliana that transgenerational stability of experimentally induced hypomethylation at TE loci is constrained by small RNAs derived from related copies. Using data from more than 700 strains collected worldwide, we uncover similar and recur...
• Oncogenes out of context: Cancer genes break free from the regulatory constraints of chromosomes AI翻译
  作者：Hung, King L.
  作者单位：Scripps Research Institute; Stanford Medicine; Stanford University; Stanford University; Stanford Medicine
• Sweeping ban on Chinese collaborations proposed AI翻译
  作者：Mervis, Jeffrey
• Texas dementia researchers cheer $3 billion initiative AI翻译
  作者：Smith, Jennie Erin
• Branched actin networks mediate macrophage-dependent host-microbiota homeostasis AI翻译
  作者：Vasconcellos, Luiz Ricardo C.; Huang, Shaina Chor Mei; Suarez-Bonnet, Alejandro; Priestnall, Simon; Chakravarty, Probir; Varsani-Brown, Sunita; Winder, Matthew L.; Shah, Kathleen; Kogata, Naoko; Stockinger, Brigitta; Way, Michael
  作者单位：Francis Crick Institute; Francis Crick Institute; University of London; University of London Royal Veterinary College; Francis Crick Institute; Francis Crick Institute; Francis Crick Institute; Imperial College London
  摘要：Branched actin networks formed by the Arp2/3 complex are essential for immune system function. Patients with loss-of-function mutations in the ARPC5 subunit of the Arp2/3 complex develop inflammation and immunodeficiency after birth, leading to early mortality. The basis for these phenotypes remains obscure. We found that loss of ARPC5, but not the ARPC5L isoform, in the mouse hematopoietic system caused early-onset intestinal inflammation after weaning. This condition was initiated by microbi...
• Targeting formyl peptide receptor 1 reduces brain inflammation and neurodegeneration AI翻译
  作者：Li, Yulin; Li, Zhiguo; Zheng, Pei; Guan, Shuzhen; Li, Yan; Yao, Nan; Qi, Zhihui; Zhang, Xueyu; Su, Lei; Jing, Jing; Wu, Siting; Zhao, Xue; Wang, Meng; Bottcher, Chotima; Ljunggren, Hans-Gustaf; Paul, Friedemann; Van Kaer, Luc; Verkhratsky, Alexei; Shi, Fu-Dong
  作者单位：Tianjin Medical University; Capital Medical University; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Karolinska Institutet; Karolinska University Hospital; Vanderbilt University; University of Manchester
  摘要：Multiple sclerosis (MS) progresses through brain region-specific inflammation and degeneration, with poorly defined mechanisms. In individuals with MS, we identified increased expression of formyl peptide receptor 1 (FPR1) in central nervous system (CNS)-resident microglia and CNS-infiltrating macrophages. Blood amounts of N-formylated peptides, which are endogenous agonists of FPR1, correlated with disease progression in patients with MS. In MS mouse models, signaling through FPR1 promoted mi...
• Idea that gut microbes contribute to autism draws fire AI翻译
  作者：O'Grady, Cathleen