作者：Zhang, Yunxiao; Kini, Sejal A.; Mishkanian, Sassan A.; Yarishkin, Oleg; Luo, Renhao; Seradj, Saba Heydari; Leung, Verina H.; Wang, Yu; Servin-Vences, M. Rocio; Keenan, William T.; Sonmez, Utku; Sanchez-Alavez, Manuel; Liu, Yuejia; Jin, Xin; Lipomi, Darren J.; Ye, Li; Petrascheck, Michael; Frolova, Antonina I.; England, Sarah K.; Patapoutian, Ardem
作者单位：Scripps Research Institute; Howard Hughes Medical Institute; University of California System; University of California San Diego; Scripps Research Institute; Universidad Autonoma de Baja California
摘要：Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. We identified mechanically activated ion channels PIEZO1 and PIEZO2 as key mechanotransducers required for labor progression. Genetic deletion of Piezo1 and Piezo2 in mice resulted in weakened uterine contractions and severe parturition defects. Tissue-specific knockouts revealed that deletion in either uterus or sensory neurons alone caused modest defects w...
作者：Evans, James; Duede, Eamon
作者：Maire, Amandine; Bikard, David
作者单位：Universite Paris Cite; Pasteur Network; Centre National de la Recherche Scientifique (CNRS); Institut Pasteur Paris; CNRS - National Institute for Biology (INSB)
