6793期

最新文章

• A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform AI翻译
  作者：Jain, Siddhant U.; Williamson, Kaylyn E.; Ying, Alexander W.; Turner, Aasha M.; Jiang, Ruidong Jerry; Raval, Shaunak; So, Kevin; Allison, Maxwell J.; Sankar, Akshay; Same Guerra, Daniel D.; Lin, Yutong; Jiang, Zhe; Mashtalir, Nazar; Rohrs, Henry W.; Lichti, Cheryl F.; Muir, Tom W.; Papanastasiou, Malvina; Paulo, Joao A.; Gygi, Steven P.; Gross, Michael L.; Kadoch, Cigall
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Washington University (WUSTL); Princeton University; Washington University (WUSTL); Washington University (WUSTL); Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
  摘要：Mammalian switch/sucrose nonfermenting (mSWI/SNF) chromatin remodeling complexes modulate DNA accessibility and gene expression; however, their genomic targeting mechanisms remain incompletely understood. Here, we identify SWIFT [SWI/SNF immunoglobulin fold (Ig-fold) for transcription factor interactions], a conserved transcription factor (TF) binding domain on the SMARCD subunits. SWIFT is necessary and sufficient for direct engagement with the transactivation domain of the PU.1 TF. A single ...
• Turning tumors against themselves AI翻译
  作者：Rosa, Fabio F.
• Flexible, abstract rhythm perception in bumble bees AI翻译
  作者：Zeng, Zijie; Barron, Andrew B.; Peng, Fei; Solvi, Cwyn
  作者单位：Southern Medical University - China; Southern Medical University - China; Macquarie University; Southern Medical University - China
  摘要：Flexible, abstract rhythm perception underpins human music, dance, and speech, but thus far, it has only been demonstrated in a few birds and mammals. In this work, we show that bumble bees also form robust abstract rhythm representations. Free-flying bees learned to discriminate two arbitrary repeating flashing light sequences, balanced to preclude the use of any local cues. Bees successfully recognized these learned rhythmic patterns at new, faster, and slower tempi. Bees trained on vibratio...
• Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis AI翻译
  作者：Zumalave, Sonia; Santamarina, Martin; Espasandin, Nuria P.; Zamora, Jorge; Garcia-Souto, Daniel; Temes, Javier; Baker, Toby M.; Rodriguez-Castro, Jorge; Otero, Paula; Pequeno-Valtierra, Ana; Otero, Iago; Oitaben, Ana; Alvarez, Eva G.; Diaz-Arias, Iria; Martinez-Fernandez, Monica; Blanco, Miguel G.; Van Loo, Peter; Cristofari, Gael; Rodriguez-Martin, Bernardo; Tubio, Jose M. C.
  作者单位：Universidade de Santiago de Compostela; Universidade de Santiago de Compostela; Francis Crick Institute; Universidade de Santiago de Compostela; Universidade de Santiago de Compostela; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); European Molecular Biology Laboratory (EMBL); Pompeu Fabra University; Barcelona Institute of Science & Technology; Centre de Regulacio Genomica (CRG); Pompeu Fabra University
  摘要：LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read sequencing, we analyzed 10 tumors with exceptionally high retrotransposition activity, comprising more than 6000 somatic events. We reveal that L1-mediated reciprocal translocations occur frequently, typically driven by two concurrent L1 retrotransposition events on nonhomologous chromosomes. Usi...
• The dawn of the Phanerozoic: A transitional fauna from the late Ediacaran of Southwest China AI翻译
  作者：Li, Gaorong; Wei, Fan; Wen, Wenwen; Wang, Xiaodong; Lei, Xiangtong; Anderson, Ross P.; Zhao, Yang; Dunn, Frances S.; Parry, Luke A.; Cong, Peiyun
  作者单位：Yunnan University; Yunnan University; Yunnan Normal University; Yunnan University; University of Oxford; University of Zurich; University of Oxford
  摘要：Animal diversification across the Ediacaran-Cambrian transition was a crucial event in Earth history, fundamentally altering our planet and its biosphere. However, Ediacaran fossil assemblages show limited overlap with those from the Cambrian, obscuring the critical interval when the animal phyla were diversifying. We report a new terminal Ediacaran fossil assemblage preserved as carbonaceous films from the Jiangchuan Biota, Yunnan, Southwest China. This assemblage diverges from coeval sites, ...
• Scientists brace for expansion of Alzheimer's blood tests AI翻译
  作者：Smith, Jennie Erin
• Fight against neonatal mortality is losing steam AI翻译
  作者：Tsanni, Abdullahi
• Onset of millennial climate variability with the intensification of Northern Hemisphere glaciation AI翻译
  作者：Hodell, David A.; Abrantes, Fatima; Alvarez Zarikian, Carlos A.; Herbert, Timothy D.; Du, Mengyao; Crowhurst, Simon J.; Mleneck-Vautravers, Maryline; Rolfe, James E.; Chen, Xi; Brooks, Hannah L.; Clark, William B.; Dauchy-Tric, Louise F. B.; Dos Santos Rocha, Viviane; Flores, Jose-Abel; Hines, Sophia K. V.; Huang, Huai-Hsuan May; Ikeda, Hisashi; Kaboth-Bahr, Stefanie; Kuroda, Junichiro; Link, Jasmin M.; Mcmanus, Jerry F.; Mitsunaga, Bryce A.; Yobo, Lucien Nana; Pallone, Celeste T.; Pang, Xiaolei; Peral, Marion Y.; Salgueiro, Emilia; Sanchez, Saray; Verma, Komal; Wu, Jiawang; Xuan, Chuang; Yu, Jimin; Haygood, Lauren A.; Liebrand, Diederik; Magalhaes, Vitor; Alonso-Garcia, Montserrat; Duque-Castano, Monica; Ferreira, Fernanda; Freitas, Mafalda; Cordeiro, Livia Gebara; Gil, Isabelle; Gonzalez-Martin, Maria; Lopes, Ana; Lopes, Cristina; Margari, Vasiliki; Martin-Garcia, Laura; Matos, Lelia; Mega, Aline; Molina, Giulia; Naughton, Filipa; Oliveira, Dulce; Rebotim, Andreia; Rodrigues, Teresa; Santana, Andre; Trejos-Tamayo, Raul; Tzedakis, Polychronis C.
  作者单位：University of Cambridge; Instituto Portugues do Mar e da Atmosfera; Universidade do Algarve; Texas A&M University System; Texas A&M University College Station; Brown University; RWTH Aachen University; University of Alabama System; University of Alabama Tuscaloosa; Universite Paris Cite; Northern Illinois University; University of Salamanca; Woods Hole Oceanographic Institution; Princeton University; Yamaguchi University; Free University of Berlin; University of Tokyo; Ruprecht Karls University Heidelberg; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University; Texas A&M University System; Texas A&M University College Station; China University of Geosciences; Centre National de la Recherche Scientifique (CNRS); Universite de Bordeaux; CNRS - National Institute for Earth Sciences & Astronomy (INSU); Oregon State University; Banaras Hindu University (BHU); Sun Yat Sen University; University of Southampton; NERC National Oceanography Centre; Laoshan Laboratory; Australian National University; Oklahoma State University System; Oklahoma State University - Stillwater; University of London; University College London; University of London; University College London; CSIC - Centro Mediterraneo de Investigaciones Marinas y Ambientales (CMIMA); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Ciencias del Mar (ICM); Universidad de Caldas
  摘要：The Quaternary Period (the past 2.58 million years) was characterized by the waxing and waning of large ice sheets in the Northern Hemisphere. Using sediment sequences from the Iberian Margin, we have demonstrated that expansion of Northern Hemisphere ice sheets around 2.7 million years ago was accompanied by the emergence of millennial climate variability (MCV) during glacial periods. The onset of MCV at similar to 2.7 million years ago was heralded by isolated precursor events, followed by m...
• Is a heralded US effort to help the world battle HIV facing extinction? AI翻译
  作者：Cohen, Jon
• Higher education must bridge the AI gap AI翻译
  作者：Miranda, Marie Lynn
  作者单位：University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital