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作者：DeWeirdt, Peter C.; Mahoney, Emily M.; Laub, Michael T.
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Johns Hopkins University; Johns Hopkins Medicine; Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT)
摘要：Antiphage defense systems protect bacteria from viral infection and have inspired important biotechnologies such as CRISPR-Cas9 while also revealing the evolutionary roots of eukaryotic innate immunity. Many systems have been discovered by genomic colocalization, but this approach cannot identify systems outside of defense islands. We present DefensePredictor, a machine learning model that uses protein language model embeddings to classify proteins as defensive. Applying DefensePredictor to 69...
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作者：Landoni, Juan C.; Lycas, Matthew D.; Macuada, Josefa; Stepp, Willi; Jaccard, Romeo; Obara, Christopher J.; Moore, Andrew S.; Hoffman, David; Lippincott-Schwartz, Jennifer; Marshall, Wallace; Sturm, Gabriel; Manley, Suliana
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Pontificia Universidad Catolica de Chile; Howard Hughes Medical Institute; University of California System; University of California San Francisco; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：The distribution of mitochondrial DNA-containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regular positioning. In this work, we found that mitochondria frequently undergo a reversible biophysical instability termed pearling, transforming from a tubular into a regularly spaced beads morphology. Physiological pearling imposed a characteristic length scale and simultaneously mediated nucleoid d...
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作者：Molina, Irene S.; Haldar, Malay
作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine
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作者：Sun, Jiazheng; Tian, Xudong; Zhang, Zhenghan; Liu, Jing; Han, Lei; Xu, Fanrong; Jiang, Han; Ma, Chao; Guo, Hongwei; Lin, Cong; Jiang, Qike; Li, Guangchao; Lo, Tsz Woon Benedict; Song, Haitao; Lin, Wei; Xu, Le; Li, Jian
作者单位：Nanjing University; Suzhou Laboratory; Nanjing Tech University; Sinopec; Hong Kong Polytechnic University; Westlake University; Chinese Academy of Sciences
摘要：Stable extra-large-pore zeolites are highly desirable for catalysis and molecular separation, but most remain microporous, limiting their effectiveness for bulky substrates. Among the few extra-large-pore zeolites that exhibit mesoporosity, the pores typically form as elongated, noncircular pore apertures. We report that NJU120-6, a stable silicate zeolite with an intrinsic cylindrical mesoporous system, has the currently largest 36-ring windows with a free diameter of 25.71 angstroms by 19.12...
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作者：Thorp, H. Holden
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作者：Byrne, James D.
作者单位：University of Iowa; University of Iowa
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作者：Rabahi, Soraya; Maurin, Lucie; Marachlian, Emiliano; Guendel, Fabian; Mikdache, Aya; Quintero-Castillo, Keinis; Di Donato, Vincenzo; Riou-Ramon, Jessica; Kurup, Akshai Janardhana; Salloum, Yazan; Gros, Gwendoline; Diabangouaya, Patricia; Garcia-Baudino, Camila; Medina-Yanez, Ignacio; Hersen, Pascal; Banderas, Alvaro; Levraud, Jean-Pierre; Lutfalla, Georges; Del Bene, Filippo; Feijoo, Carmen G.; Eberl, Gerard; Sumbre, German; Boekhorst, Jos; Brugman, Sylvia; Hernandez, Pedro P.
作者单位：Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Universite PSL; CNRS - National Institute for Biology (INSB); Institut Curie; Universite PSL; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Ecole Normale Superieure (ENS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Pasteur Network; Institut Pasteur Paris; Universidad Andres Bello; Universidad Andres Bello; Universidad Andres Bello; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); UNICANCER; Sorbonne Universite; Universite PSL; CNRS - Institute of Chemistry (INC); Institut Curie; Leibniz Association; Leibniz Institut fur Neue Materialien (INM); Universite Paris Cite; Pasteur Network; Universite Paris Saclay; Institut Pasteur Paris; Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Animal Sciences Group of Wageningen UR; Wageningen University & Research; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris-Est-Creteil-Val-de-Marne (UPEC)
摘要：The gut microbiota, immune system, and enteric nervous system interact to regulate adult gut physiology. However, the mechanisms establishing gut physiology during development remain unknown. We report that in developing zebrafish, enteroendocrine cells produced interleukin-22 (IL-22) in response to microbial signals before lymphocytes populated the gut. In larvae, IL-22 shaped the gut microbiota, increasing Lactobacillaceae abundance and ghrelin expression to promote gut motility. Impaired mo...
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作者：Sayour, Elias J.
作者单位：State University System of Florida; University of Florida
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作者：Clery, Daniel
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作者：Cohen, Jon
