6793期

最新文章

• Open Space: From Earth to Eternity-the Global Race to Explore and Conquer the Cosmos AI翻译
  作者：Herndon, Jaime
• To mate or predate?: Octopuses use the same system for sensing food or a mate, which has implications for speciation AI翻译
  作者：Di Cosmo, Anna
  作者单位：University of Naples Federico II
• A call to serve AI翻译
  作者：Ramasubramanian, Ashok
  作者单位：Union College; Union College
• Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity AI翻译
  作者：You, Zhiyuan; Kim, Jiyeon; Guo, Chuansheng; Hu, Haoran; Chapman, Nicole M.; Meng, Xiaoxi; Shi, Hao; Wang, Yan; Guy, Cliff; Kc, Anil; Li, Jia; Saravia, Jordy; Palacios, Gustavo; Rankin, Sherri; Robinson, Camenzind G.; Chi, Hongbo
  作者单位：St Jude Children's Research Hospital; St Jude Children's Research Hospital
  摘要：Antitumor immunity requires conventional type 1 dendritic cells (cDC1s). How cDC1s maintain functional fitness in the tumor microenvironment remains unclear. In this study, we established that intratumoral cDC1s exhibited discrete mitochondrial states and that OPA1-mediated mitochondrial energy and redox metabolism dictated cDC1 antitumor responses. Mechanistically, OPA1 orchestrated antigen presentation and the CD8+ T cell priming function of cDC1s by promoting nuclear respiratory factor 1 (N...
• Support Iran's diaspora scholars AI翻译
  作者：Mohammadmoradi, Shayan
  作者单位：University of Kentucky; University of Kentucky
• Strategies for achieving healthy, sustainable, and equitable dietary transitions AI翻译
  作者：Yang, Yi; Tilman, David; Bellemare, Marc F.; Fanzo, Jessica; Grebitus, Carola; Haws, Kelly L.; Herrero, Mario; Jebb, Susan A.; Just, David R.; Levine, Allen S.; McClements, David Julian; Mouritsen, Ole G.; Pechey, Rachel; Barrett, Christopher B.
  作者单位：Chongqing University; Chongqing University; University of Minnesota System; University of Minnesota Twin Cities; University of California System; University of California Santa Barbara; University of Minnesota System; University of Minnesota Twin Cities; Johns Hopkins University; Arizona State University; Arizona State University-Tempe; Vanderbilt University; Cornell University; Cornell University; University of Oxford; Cornell University; University of Minnesota System; University of Minnesota Twin Cities; University of Massachusetts System; University of Massachusetts Amherst; University of Copenhagen; Cornell University
  摘要：The industrialization of global food systems has led to dietary changes that harm both health and the environment. If global food systems are to meet the needs of a growing population for healthy, environmentally sustainable, and affordable diets, substantial changes will be required. In this Review, we synthesize growing empirical evidence on the complexity of factors that influence consumer dietary and farmer production choices, especially the roles of public and private entities that shape ...
• Cumulative pressures threaten the Red Sea AI翻译
  作者：Adombi, Adoubi Vincent De Paul; Yaseen, Zaher Mundher
  作者单位：University of Quebec; University of Quebec Chicoutimi; King Fahd University of Petroleum & Minerals
• Protein and genomic language models uncover the unexplored diversity of bacterial immunity AI翻译
  作者：Mordret, Ernest; Herve, Alexandre; Tesson, Florian; Vaysset, Hugo; Clabby, Tyler; Loubat, Arthur; Shomar, Helena; Planel, Remi; Lavenir, Rachel; Cury, Jean; Bernheim, Aude
  作者单位：Universite Paris Cite; Pasteur Network; Centre National de la Recherche Scientifique (CNRS); Institut Pasteur Paris; CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; AgroParisTech; Universite Paris Saclay; Universite Paris Cite; Pasteur Network; Institut Pasteur Paris
  摘要：The bacterial pangenome contains a vast diversity of antiphage systems, whose overall extent is still unknown. In this study, we developed complementary machine learning approaches to systematically predict antiphage function from genomic context, protein sequence, or their combination, achieving up to 99% precision and 92% recall. We validated these models experimentally in Escherichia and Streptomyces with the discovery of 12 antiphage systems. Applied to over 32,000 bacterial genomes, these...
• A sensory system for mating in octopus AI翻译
  作者：Villar, Pablo S.; Jiang, Hao; Shugaeva, Tatiana; Berdan, Emma L.; Kulkarni, Arpita; Hiroi, Makoto; Masucci, Giovanni; Reiter, Sam; Lindahl, Erik; Howard, Rebecca J.; Hibbs, Ryan E.; Bellono, Nicholas W.
  作者单位：Harvard University; University of California System; University of California San Diego; Royal Institute of Technology; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard Medical School; Okinawa Institute of Science & Technology Graduate University; Stockholm University; Linkoping University; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Sensory systems for mate recognition maintain species boundaries and influence diversification. Thus, uncovering how molecules and receptors evolve to mediate this critical function is essential to understanding biodiversity. Male octopuses use a specialized arm called the hectocotylus to identify females and navigate their internal organs to reach the oviduct and deliver sperm. Here, we discovered that the hectocotylus is a dual sensory and mating organ that uses contact-dependent chemosensat...
• Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response AI翻译
  作者：Reineke, Lucas C.; Zhu, Ping Jun; Dalwadi, Udit; Dooling, Sean W.; Liu, Yuwei; Wang, I-Ching; Young-Baird, Sara; Okoh, James; Kuncha, Santosh Kumar; Zhou, Hongyi; Kannan, Akshara; Park, Hyekyung; Debeaubien, Nicolas A.; Croll, Tristan; Lee, D. John; Arthur, Christopher; Dever, Thomas E.; Walter, Peter; Chen, Jin; Frost, Adam; Costa-Mattioli, Mauro
  作者单位：Baylor College of Medicine; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); Uniformed Services University of the Health Sciences - USA
  摘要：The integrated stress response (ISR) is essential for cellular homeostasis and cognitive function. We investigated how persistent ISR activation affects cognitive performance by studying the PPP1R15BR658C genetic variant associated with intellectual disability. To model this condition, we generated a mouse line with the pathogenic allele inserted. This variant destabilized the PPP1R15B center dot PP1 phosphatase complex, causing persistent ISR activation, impaired protein synthesis, and long-t...