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作者:Wang, Yue; Zhao, Yu; Zhang, Yifei; Zhang, Liutianyi; Zhong, Zijian; Liu, Sishuo; Hou, Chentao; Liu, Fanxin; Zhang, Bin-Bin; Wei, Zhongming; Liu, Yue-Yang; Wang, Han; Tan, Ping-Heng; Wu, Jiangbin
作者单位:Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Semiconductors, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Hong Kong; Zhejiang University of Technology; National University of Defense Technology - China; Zhangjiang Laboratory
摘要:Nonvolatile memories should store information reliably while consuming little energy. Ferroelectric tunnel junctions offer compact readout, but conventional ionic displacement ferroelectrics can fatigue, and two-dimensional sliding ferroelectrics are robust but generate weak readout in two terminal devices. We engineered a van der Waals junction using rhombohedral molybdenum disulfide, hexagonal boron nitride, monolayer graphene, and chromium. This architecture converts small sliding polarizat...
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作者:Wani, Zishan Ahmad
作者单位:SRM University-AP; King Abdullah University of Science & Technology
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作者:Li, Qilin; Liu, Junli; Chen, Si; Hu, Yixuan; Li, Dengfeng; Su, Zhuojie; Zhang, Yanxiao; Yu, Xiaochun
作者单位:Westlake University; Westlake Laboratory
摘要:The mouse Y chromosome is essential for male reproduction, yet the GRCm39 reference contains 25 gaps, particularly in repetitive and complex regions. Here, we assembled a telomere-to-telomere Y chromosome (mT2T Y) of 95.21 Mb from a C57BL/6 mouse incorporating parental genomes. This assembly fills all gaps, corrects structural errors, and adds over 8.70 Mb of previously unassembled sequence to the reference genome. We annotated 142 previously unidentified genes, identified Y specific satellite...
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作者:Liang, Tao; Meiri, Shai; Roll, Uri
作者单位:Ben-Gurion University of the Negev; Tel Aviv University; University of Melbourne; Ben-Gurion University of the Negev
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作者:Zhu, Jiangwei; Xie, Kun; Wang, Min; Guo, Meixia; Yang, Zekai
作者单位:Nanjing Forestry University; Kashi University; Northeastern University - China; Henan University
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作者:de Sautu, Marilina; Leistner, Conny; Kirchhausen, Tomas; Jenni, Simon; Harrison, Stephen C.
作者单位:Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard University; Howard Hughes Medical Institute; Harvard Medical School
摘要:Cell entry of nonenveloped animal viruses requires translocation of a macromolecular assembly across a cellular membrane. Double-stranded RNA viruses introduce into the target cell an inner capsid particle that does not uncoat further. Instead, it extrudes capped viral mRNA by virtue of polymerase and capping activities within it. As described here, we used cryogenic electron tomography to visualize the full course of rhesus rotavirus entry, from cell attachment and virion uptake to release of...
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作者:Qin, Hehao; Liu, Maodian; Zhang, Yanxu; Zhang, Qianru; Xiao, Changhao; Zhou, Chengzhen; Cai, Xingrui; Qiu, Xinran; Wang, Xuejun
作者单位:Peking University; Yale University; Peking University; Tulane University; Duke University; University of London; University College London; Peking University
摘要:Rivers are key conduits in the global microplastic cycle, but how much they export to ` ocean and what controls this export remain unresolved. Here, we present a global daily dataset of riverine microplastic concentrations and exports and find that rivers delivered far more microplastics to the ocean than most previous estimates suggest. Ninety-six percent of this export originated in the Global South, with Southeast and East Asia contributing >50% of the total flux. Furthermore, similar to 70...
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作者:Angrist, Noam; Andrabi, Tahir; Dercon, Stefan; Djaker, Sharnic; Habyarimana, James; Kaffenberger, Michelle; Leaver, Clare; Mangla, Akshay; Mohohlwane, Nompumelelo; Singh, Abhijeet
作者单位:University of Oxford; Claremont Colleges; Pomona College; Georgetown University; University of Oxford; Stockholm School of Economics
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作者:Wang, Dan
作者单位:Stanford University
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作者:Curtin, Meghan C.; Jackson, Abigail E.; Lee, Mark D.; Brown, Elisabeth A.; Maschek, J. Alan; Lum, David H.; Cox, James E.; Welm, Alana L.; Hilgendorf, Keren I.
作者单位:Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Huntsman Cancer Institute
摘要:Obesity increases breast cancer risk and tumor aggressiveness, yet the mechanisms underlying this association remain unclear. In this work, we identify a tumor-suppressive lipid signaling pathway in which mammary adipocytes secrete the oxylipin 9S-hydroxyoctadecadienoic acid (9S-HODE). 9S-HODE induces ferroptosis in breast cancer cells by disrupting iron homeostasis. Adipocytes in obese mammary tissue produce less 9S-HODE, and tumors in obese mice exhibit reduced ferroptosis. Accordingly, ferr...