作者：Sharma, Monica; Katz, Zachary B.; Dewitt, David C.; Ruff, Kiersten M.; Singh, Akashdip; Lan, Huan; Phung, Wilson; Tom, Jeffery; Song, Aimin; Sudhamsu, Jawahar; Davies, John; Quinn, John G.; Pappu, Rohit V.; Shaw, Andrey S.
作者单位：Washington University (WUSTL); Washington University (WUSTL)
摘要：T cell receptor (TCR) engagement stimulates formation of a biomolecular condensate, including the scaffold protein linker of activated T cells (LAT). We investigated whether the immune-inhibitory receptor programmed cell death protein 1 (PD-1) inhibits by impeding TCR-induced LAT condensation. In vitro reconstitutions revealed that the cytoplasmic domain of PD-1 directly inhibited LAT condensation. This inhibitory interaction required tyrosine residues in the two inhibitory motifs of PD-1. Con...
作者：Wang, Ruiqing; Zhu, Feng; Qian, Haoji; Zhou, Jiuren; Sun, Wenxin; Zheng, Siying; Chen, Jiajia; Li, Bochang; Liu, Yan; Zhou, Peng; Hao, Yue; Han, Genquan
作者单位：Xidian University; City University of Hong Kong; Xidian University; Fudan University
摘要：Wurtzite ferroelectrics could provide a route to wafer-scale integrated ferroelectric memories but are limited by endurance, typically failing at similar to 10(8) cycles. We identified nitrogen-vacancy (V-N) clustering and long-range percolative migration as the defect-mediated pathways that drive leakage-current growth and dielectric breakdown. We combined a spatially engineered aluminum scandium nitride/aluminum nitride (AlScN/AlN) superlattice with a dynamic recovery protocol to spatially a...
