6816期

最新文章

• How the hunt for human retroviruses led to the discovery of interleukin-2 and a path to immunotherapy AI翻译
  作者：Ahmed, Rafi; Rosenberg, Steven
  作者单位：Emory University; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
• Clues to immune havoc in the brain AI翻译
  作者：Smith, Jennie Erin
• Discovery of an intrinsic non-Hermitian phase transition in a bulk condensed-matter system AI翻译
  作者：Li, Jingwen; Turaev, Michael; Matsubara, Masakazu; Kliemt, Kristin; Krellner, Cornelius; Pal, Shovon; Fiebig, Manfred; Kroha, Johann
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Bonn; University of Bonn; Tohoku University; Japan Science & Technology Agency (JST); Goethe University Frankfurt; University of St Andrews
  摘要：Across regular phase transitions, systems remain in thermal equilibrium. However, when a system is driven far from equilibrium, non-Hermitian phase transitions may arise where the dynamical behavior-rather than steady properties-undergoes a qualitative change at a critical, so-called exceptional point. We experimentally realize a non-Hermitian phase transition in a bulk condensed-matter system. Optical excitation creates charge carriers in ferromagnetic europium monoxide. In a temperature-depe...
• The parent bodies of Ryugu and Ivuna formed before those of other carbonaceous chondrites AI翻译
  作者：Kawasaki, Noriyuki; Nagashima, Kazuhide; Sakamoto, Naoya; Fujiya, Wataru; Arakawa, Sota; Bajo, Ken-ichi; Kita, Noriko T.; Kitajima, Kouki; Krot, Alexander N.; Huss, Gary R.; Abe, Yoshinari; Aleon, Jerome; Alexander, Conel M. O'D.; Amari, Sachiko; Amelin, Yuri; Bizzarro, Martin; Bouvier, Audrey; Carlson, Richard W.; Chaussidon, Marc; Choi, Byeon-Gak; Dauphas, Nicolas; Davis, Andrew M.; Di Rocco, Tommaso; Fukai, Ryota; Gautam, Ikshu; Haba, Makiko K.; Hibiya, Yuki; Hidaka, Hiroshi; Homma, Hisashi; Iizuka, Tsuyoshi; Ireland, Trevor R.; Ishikawa, Akira; Itoh, Shoichi; Kleine, Thorsten; Komatani, Shintaro; Liu, Ming-Chang; Masuda, Yuki; Motomura, Kazuko; Moynier, Frederic; Nakai, Izumi; Nguyen, Ann; Nittler, Larry; Pack, Andreas; Park, Changkun; Piani, Laurette; Qin, Liping; Russell, Sara S.; Schonbachler, Maria; Terada, Kentaro; Terada, Yasuko; Usui, Tomohiro; Wada, Sohei; Wadhwa, Meenakshi; Walker, Richard J.; Yamashita, Katsuyuki; Yin, Qing-Zhu; Yokoyama, Tetsuya; Yoneda, Shigekazu; Young, Edward D.; Yui, Hiroharu; Zhang, Ai-Cheng; Nakamura, Tomoki; Naraoka, Hiroshi; Noguchi, Takaaki; Okazaki, Ryuji; Sakamoto, Kanako; Yabuta, Hikaru; Abe, Masanao; Miyazaki, Akiko; Nakato, Aiko; Nishimura, Masahiro; Okada, Tatsuaki; Yada, Toru; Yogata, Kasumi; Nakazawa, Satoru; Saiki, Takanao; Tanaka, Satoshi; Terui, Fuyuto; Tsuda, Yuichi; Watanabe, Sei-ichiro; Yoshikawa, Makoto; Tachibana, Shogo; Yurimoto, Hisayoshi
  作者单位：Hokkaido University; University of Hawaii System; University of Hawaii Manoa; Hokkaido University; Ibaraki University; Japan Agency for Marine-Earth Science & Technology (JAMSTEC); University of Wisconsin System; University of Wisconsin Madison; Tokyo Denki University; Museum National d'Histoire Naturelle (MNHN); Sorbonne Universite; Washington University (WUSTL); Washington University (WUSTL); Chinese Academy of Sciences; Guangzhou Institute of Geochemistry, CAS; University of Copenhagen; University of Bayreuth; Universite Paris Cite; Seoul National University (SNU); University of Chicago; University of Hong Kong; University of Gottingen; Japan Aerospace Exploration Agency (JAXA); Institute of Space & Astronautical Science (ISAS); Institute of Science Tokyo; University of Tokyo; Japan Agency for Marine-Earth Science & Technology (JAMSTEC); Nagoya University; Rigaku Corporation; University of Tokyo; University of Queensland; Kyoto University; Max Planck Society; University of California System; University of California Los Angeles; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Rigaku Corporation; Tokyo University of Science; National Aeronautics & Space Administration (NASA); NASA Johnson Space Center; Korea Polar Research Institute (KOPRI); Universite de Lorraine; Centre National de la Recherche Scientifique (CNRS); Chinese Academy of Sciences; University of Science & Technology of China, CAS; Natural History Museum London; University of Osaka; Japan Synchrotron Radiation Research Institute; Arizona State University; Arizona State University-Tempe; University System of Maryland; University of Maryland College Park; Okayama University; University of California System; University of California Davis; National Museum of Nature and Science; Tokyo University of Science; Nanjing University; Tohoku University; Kyushu University; Hiroshima University; Kanagawa Institute Technology; University of Tokyo
  摘要：Most carbonaceous chondrite (CC) meteorites contain abundant chondrules, millimeter-scale spherical inclusions of previously molten material. Ivuna-type carbonaceous chondrites (CIs) do not contain chondrules, nor do samples of the carbonaceous asteroid Ryugu. CIs and Ryugu share isotopic properties distinct from those of other CCs, implying that their parent bodies formed at a different time or place than those of other CCs. We applied manganese-chromium dating and oxygen isotope thermometry ...
• Decondensing cancer immunotherapy AI翻译
  作者：Chakraborty, Arup K.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University
• Scientists question US Forest Service's rationale for rescinding 'roadless rule' AI翻译
  作者：Cornwall, Warren
• Paleogenomics and habitat modeling reveal temperate Eurasian origins of woolly rhinoceroses AI翻译
  作者：Lei, Xiao-Le; Ruan, Jiaoyang; Liang, Xueyuan; Teixeira, Raquel; Zhang, Jiangyue; Gilardet, Alexandre; Zhou, Xu; Han, Yu; Zhao, Zhihan; Yue, Hai-Yan; Kozlikin, Maxim; Vasiliev, Sergey; Medvedev, Stanislav; Kruskop, Sergei; Xing, Song; Wang, Ting; Basova, Vera; Ma, Lijuan; Shi, Bohua; Shao, Qingfeng; Douka, Katerina; Shunkov, Michael; Buzhilova, Alexandra; Dalen, Love; Yu, He
  作者单位：Peking University; Peking University; Tsinghua University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Geology & Geophysics, CAS; Institute for Basic Science - Korea (IBS); Swedish Museum of Natural History; Universidade de Lisboa; Stockholm University; Russian Academy of Sciences; Institute of Archaeology & Ethnography, Siberian Branch of Russian Academy of Sciences; Siberian Branch of the Russian Academy of Sciences; Lomonosov Moscow State University; Lomonosov Moscow State University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Suihua University; Nanjing Normal University; University of Vienna; University of Vienna; Swedish Museum of Natural History
  摘要：The woolly rhinoceros was a prominent Ice Age megafaunal species, and there is limited knowledge regarding its origin and responses to past glacial cycles. We sequenced 29 mitochondrial and 14 nuclear genomes from Pleistocene specimens across Eurasia and modeled the species' habitats over the past 500,000 years. Our results suggest that its maternal genetic diversity mainly evolved in temperate Eurasia around 460 thousand to 420 thousand years ago during a prolonged glacial-interglacial transi...
• Manipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcription AI翻译
  作者：Wiesbeck, Maximilian; Alard, Emilie L.; Merino, Florencia; Chowdhury, Niti; Egert, Luisa; Danese, Anna; Imhof, Simon; Iraci Borgia, Matilde; Rajan, Akshaya; Fernandez-Novel Marx, Nadine; Kepesidis, Edina; Koeferle, Anna; Cerron-Alvan, Luis Miguel; Vierl, Franziska; Truong, Thi-Tram; Thorwirth, Manja; Bilalli, Lorina; Santos Dias Mourao, Andre; Ninkovic, Jovica; Schieweck, Rico; Diefenbacher, Markus; Hauck, Stefanie M.; Trainor, Paul A.; Mardakheh, Faraz K.; Goetz, Magdalena; Stricker, Stefan H.
  作者单位：University of Munich; University of Oxford; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; University of Luxembourg; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Stowers Institute for Medical Research; University of Kansas; University of Kansas Medical Center; University of Geneva; Boehringer Ingelheim
  摘要：Ribosomal RNA (rRNA) transcription rates vary during development, and their dysregulation is linked to diseases such as cancer and ribosomopathies. Owing to their high abundance and genomic redundancy, the functional significance of rRNA levels remains unclear. We developed TAPIR (Targeted Activation of Protein Translation), a CRISPR-based approach to elevate rRNA levels by inducing 47S ribosomal DNA transcription. TAPIR increased nucleolar size and enhanced protein synthesis, even in rapidly ...
• Water, Carbon, Time: Exploring Peatlands in a Warming World AI翻译
  作者：Boon, Sarah
• Chronic type II interferon promotes tumor growth through mitochondrial RNA-induced type I interferon and prostaglandin synthesis AI翻译
  作者：Johnson, Melissa A.; Varanasi, Siva Karthik; Mangalhara, Kailash Chandra; Lande, Kathryn; Rojas, Gladys R.; Esparza-Molto, Pau B.; Reynolds, Mack B.; Olliffe, Neva; Wessendorf-Rodriguez, Karl; Ghosh, Sagnika; Chen, Dan; Moyzis, Alexandra G.; Donnelly, Matthew P.; Chinn, Rebecca; Xu, Ziyan; Grae, Kym J.; Tripple, Victoria; LaPorta, Michael A.; Metallo, Christian M.; Hargreaves, Diana C.; Kaech, Susan M.; Shadel, Gerald S.
  作者单位：Salk Institute; University of California System; University of California San Diego; Sanford Burnham Prebys Medical Discovery Institute; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Salk Institute; University of Massachusetts System; University of Massachusetts Worcester
  摘要：Interferons (IFNs) are proinflammatory cytokines that promote immune cell engagement to eliminate malignant cells. Paradoxically, chronic interferon signaling can also activate anti-inflammatory mechanisms that allow cancer cells to evade the immune system. In this study, we sought to determine the cellular mechanisms underlying this switch from antitumorigenic to protumorigenic interferon activity. We show that chronic type II interferon (IFN-II) exposure distinctively induced tumor growth by...