6787期

最新文章

• In search of meaning AI翻译
  作者：Perlman, Marcus; Winter, Bodo
  作者单位：University of Birmingham
• Evolution of error correction through a need for speed AI翻译
  作者：Ravasio, Riccardo; Husain, Kabir; Evans, Constantine G.; Phillips, Rob; Ribezzi-Crivellari, Marco; Szostak, Jack W.; Murugan, Arvind
  作者单位：University of Chicago; University of London; University College London; University of London; University College London; Maynooth University; California Institute of Technology; Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); University of Chicago; Howard Hughes Medical Institute
  摘要：Kinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to evolve when selection for fidelity outweighs costs in energy and the speed of replication. We show that when stalling after misincorporations is accounted for, proofreading can instead speed up replication. Consistent with data on polymerase mutagenesis, our results suggest that proofreading can e...
• The oncogenome of the domestic cat AI翻译
  作者：Francis, Bailey A.; Ludwig, Latasha; He, Chang; Dobromylskyj, Melanie; Bertram, Christof A.; Aupperle-Lellbach, Heike; Wong, Hannah; Foster, Aiden P.; Arends, Mark J.; Suarez-Bonnet, Alejandro; Priestnall, Simon L.; Tatiersky, Laetitia; Castillo-Alcala, Fernanda; Rupp, Angie; Khachadoorian, Arlene; Parlak, Eda; Inglebert, Marine; Umamaheswaran, Shevaniee; Cheema, Saamin; Del Castillo Velasco-Herrera, Martin; Wong, Kim; Vermes, Ian C.; Billington, Jamie; Rottenberg, Sven; Wood, Geoffrey A.; Adams, David J.; Van Der Weyden, Louise
  作者单位：Wellcome Trust Sanger Institute; University of Guelph; Cornell University; University of Bern; University of Bern; University of Veterinary Medicine Vienna; LABOKLIN GmbH & Co. KG; Technical University of Munich; University of Cambridge; University of Bristol; University of Edinburgh; University of London; University of London Royal Veterinary College; Massey University; University of Glasgow; University of Bern; University of Bern
  摘要：Cancer is a common cause of morbidity and mortality in domestic cats. Because the mutational landscape of domestic cat tumors remains uncharacterized, we performed targeted sequencing of 493 feline tumor-normal tissue pairs from 13 tumor types, focusing on the feline orthologs of similar to 1000 human cancer genes. TP53 was the most frequently mutated gene, and the most recurrent copy number alterations were loss of PTEN or FAS or gain of MYC. By identifying 31 driver genes, mutational signatu...
• Brazil endangers global climate and health AI翻译
  作者：Machado, Carlos Jose Saldanha; Vilani, Rodrigo Machado; Fearnside, Philip M.
  作者单位：Fundacao Oswaldo Cruz; Universidade Federal do Estado do Rio de Janeiro; Institute Nacional de Pesquisas da Amazonia
• Who is using AI to code? Global diffusion and impact of generative AI AI翻译
  作者：Daniotti, Simone; Wachs, Johannes; Feng, Xiangnan; Neffke, Frank
  作者单位：Utrecht University; Corvinus University Budapest; Eotvos Lorand University; ELTE Centre for Economic & Regional Studies
  摘要：Generative coding tools promise big productivity gains, but uneven uptake could widen skill and income gaps. We train a neural classifier to spot artificial intelligence (AI)-generated Python functions in more than 30 million GitHub commits by 160,097 software developers, tracking how fast, and where, these tools take hold. Currently, AI writes an estimated 29% of Python functions in the US-a shrinking lead over other countries. We estimate that quarterly output, measured in online code contri...
• An instructive experiment AI翻译
  作者：He, Yunteng
• Unorthodox 'vaccine' offers broad protection in mice AI翻译
  作者：Leslie, Mitch
• Carbonated ultramafic igneous rocks in Jezero crater, Mars AI翻译
  作者：Williford, Kenneth H.; Farley, Kenneth A.; Horgan, Briony H. N.; Garczynski, Brad; Treiman, Allan H.; Gupta, Sanjeev; Jones, Alexander J.; Siljestrom, Sandra; Clave, Elise; Mayhew, Lisa; Osterhout, Jeffrey T.; Ravanis, Eleni; Stack, Kathryn M.; Fagents, Sarah; Bedford, Candice C.; Bosak, Tanja; Bykov, Sergei V.; Flannery, David; Hand, Kevin P.; Jones, Michael W. M.; Kah, Linda; Klidaras, Athanasios; Maki, Justin; Mandon, Lucia; Mansbach, Elias; McCubbin, Francis M.; Simon, Justin I.; Srivastava, Anushree; Uckert, Kyle; Wiens, Roger C.; Alwmark, Sanna; Aramendia, Julene; Barnes, Robert; Beck, Pierre; Bell, James F.; Bernard, Sylvain; Bhartia, Rohit; Bramble, Michael S.; Brown, Adrian J.; Broz, Adrian; Buckner, Denise; Catling, David C.; Cloutis, Edward; Connell, Stephanie; Corpolongo, Andrea; Czaja, Andrew D.; Dehouck, Erwin; Fornaro, Teresa; Forni, Olivier; Haney, Nikole C.; Hickman-Lewis, Keyron; Hug, William; Koeppel, Ari; Madariaga, Juan Manuel; Martinez-Frias, Jesus; Nunez, Jorge I.; Orenstein, Brendan J.; Phua, Yu Yu; Pilorget, Cedric; Randazzo, Nicolas; Royer, Clement; Scheller, Eva L.; Schmitz, Nicole; Schroder, Susanne; Sephton, Mark A.; Sharma, Shiv; Sharma, Sunanda; Shuster, David; Sinclair, Kimberly P.; Steele, Andrew; Tate, Christian; Weiss, Benjamin; Williams, Amy J.; Wolf, Z. Uriah; Yingst, R. Aileen
  作者单位：California Institute of Technology; Purdue University System; Purdue University; Western Washington University; Universities Space Research Association (USRA); Imperial College London; RISE Research Institutes of Sweden; Helmholtz Association; German Aerospace Centre (DLR); University of Colorado System; University of Colorado Boulder; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); University of Hawaii System; University of Hawaii Manoa; Massachusetts Institute of Technology (MIT); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Queensland University of Technology (QUT); Queensland University of Technology (QUT); University of Tennessee System; University of Tennessee Knoxville; Institut de Planetologie et d'Astrophysique de Grenoble (IPAG); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); University of Cambridge; National Aeronautics & Space Administration (NASA); NASA Johnson Space Center; Carnegie Institution for Science; Lund University; University of Basque Country; Arizona State University; Arizona State University-Tempe; Museum National d'Histoire Naturelle (MNHN); Universite Paris Cite; State University System of Florida; University of Florida; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; University of Washington; University of Washington Seattle; University of Winnipeg; University System of Ohio; University of Cincinnati; Ecole Normale Superieure de Lyon (ENS de LYON); Universite Lyon 1; Istituto Nazionale Astrofisica (INAF); Universite de Toulouse (EPE); Communaute d'universites et etablissements de Toulouse (Comue); Texas State University System; Texas State University San Marcos; University of London; Birkbeck University London; Dartmouth College; Complutense University of Madrid; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UCM - Instituto de Geociencias (IGEO); Johns Hopkins University; Johns Hopkins University Applied Physics Laboratory; Universite Paris Saclay; Sorbonne Universite; University of Alberta; Universite Paris Saclay; Stanford University; University of California System; University of California Berkeley; Cornell University; United States Department of Energy (DOE); Los Alamos National Laboratory
  摘要：The Perseverance rover landed in Jezero crater on Mars, which once contained a lake of liquid water. We report the rock properties encountered by Perseverance during a 10-kilometer traverse extending over 400 meters in elevation, from beneath Jezero's western sedimentary fan to the upper crater rim. These rocks consist of coarse-grained olivine, magnesium and iron carbonates, silica, and phyllosilicates, including some of the oldest materials exposed within Jezero. We infer that these rocks fo...
• Scimitar-crested Spinosaurus species from the Sahara caps stepwise spinosaurid radiation AI翻译
  作者：Sereno, Paul C.; Vidal, Daniel; Myhrvold, Nathan P.; Johnson-Ransom, Evan; Ciudad Real, Maria; Baumgart, Stephanie L.; Sanchez Fontela, Noelia; Green, Todd L.; Saitta, Evan T.; Adamou, Boube; Bop, Lauren L.; Keillor, Tyler M.; Fitzgerald, Erin C.; Dutheil, Didier B.; Laroche, Robert A. S.; Demers-Potvin, Alexandre V.; Simarro, Alvaro; Gasco-Lluna, Francesc; Lazaro, Ana; Gamonal, Arturo; Beightol, Charles V.; Reneleau, Vincent; Vautrin, Rachel; Bertozzo, Filippo; Granados, Alejandro; Kinney-Broderick, Grace; Mallon, Jordan C.; Lindoso, Rafael M.; Ramezani, Jahandar
  作者单位：University of Chicago; University of Chicago; Universidad Nacional de Educacion a Distancia (UNED); Intellectual Ventures; State University System of Florida; University of Florida; New York Institute Technology; Arkansas State University; Abdou Moumouni University; Museum National d'Histoire Naturelle (MNHN); Rice University; McGill University; University of Valencia; Royal Belgian Institute of Natural Sciences; Universidad de Malaga; University of Cambridge; Instituto Federal do Maranhao; Massachusetts Institute of Technology (MIT)
  摘要：We describe a close relative of Spinosaurus aegyptiacus, the sail-backed, fish-eating giant from nearshore deposits of northern Africa. Spinosaurus mirabilis sp. nov., discovered in the central Sahara alongside long-necked dinosaurs in a riparian habitat, is distinguished by a scimitar-shaped bony crest projecting far above its skull roof. We discern three discrete phases in spinosaurid evolution. During the first phase with roots in the Jurassic, an elongate fish-snaring skull emerged that so...
• Simple unilateral rupture of the great Mw 8.8 2025 Kamchatka earthquake AI翻译
  作者：Liu, Chengli; Bai, Yefei; Lay, Thorne; He, Ping; Wen, Yangmao; Xiong, Xiong; Taymaz, Tuncay
  作者单位：China University of Geosciences; China University of Geosciences; Zhejiang Ocean University; Donghai Laboratory; Zhejiang University; University of California System; University of California Santa Cruz; Wuhan University; Istanbul Technical University; Istanbul Technical University
  摘要：On 29 July 2025, a moment magnitude (Mw) 8.8 great earthquake ruptured along offshore southern Kamchatka, with the aftershock region overlapping that of a 1952 Mw 8.8 to 9.0 event. Like 1952, the 2025 event nucleated at the northeastern end of the rupture, preceded by intense foreshock activity. Joint inversion of teleseismic and InSAR (Interferometric Synthetic Aperture Radar) data for the space-time slip distribution, with validation by means of forward modeling of deep-water tsunami recordi...