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作者：Schwarz, Andre; Mueller, Mara; Will, Helene; Dietrich, Lea; Giandomenico, Stefano L.; Tushev, Georgi; Bartnik, Ina; Khusainov, Iskander; Fusco, Claudia M.; Schuman, Erin M.
作者单位：Max Planck Society; Radboud University Nijmegen; Max Planck Society; European Molecular Biology Laboratory (EMBL)
摘要：Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formation of inactive ribosome-ribosome clusters (disomes). We used cryo-electron tomography (cryo-ET) to visualize ribosomes in situ and observed that this ribosome dimerization was mediated by a homotypic interaction of the ribosomal RNA (rRNA) expansion segment ES31Lb. ES31Lb interactions were both nec...
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作者：Liang, Kangkai; Wang, Zihao; Quan, Weike; Shi, Yueqing; Zhou, Hao; Bi, Liya; Yin, Zhiyuan; Romero, Nathan; Young, Mark; Li, Shaowei
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：Probing vibrations at the single-molecule level is essential for achieving bond-specific chemical control in realistic heterogeneous environments. Here, we introduce a new measurement scheme that integrates frequency-tunable infrared excitation with scanning tunneling microscopy to characterize vibration-mediated nuclear motions of single molecules. We first validated the technique by monitoring the infrared-induced rotation of the ethynyl radical and then applied it to mapping pyrrolidine's c...
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作者：Cornwall, Warren
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作者：Kaiser, Jocelyn; Langin, Katie; Stokstad, Erik
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作者：Kim, Jae Gon; Cron, Greg O.; Kim, Minsoo; Hossain, Aronee; Lee, Jin Hyung
作者单位：Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford University
摘要：Empathy measured through observational fear in rodents has been associated with increased theta oscillations in the anterior cingulate cortex (ACC). However, upstream circuit mechanisms modulating these oscillations and the extent of the oscillations' role in empathy-related behaviors remain elusive. We found that in mice, ACC theta oscillations are involved in empathy-driven prosocial allogrooming. Moreover, orexinergic neurons are selectively activated in the ACC during observational fear an...
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作者：Banks, Ian; Narang, Prineha
作者单位：University of California System; University of California Los Angeles
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作者：Wu, Lingfei; Vasilescu, Bogdan
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Carnegie Mellon University
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作者：Qin, Linjun; Yang, Lili; Liu, Guorui; Zheng, Minghui
作者单位：Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Zhejiang Normal University
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作者：De Miguel, Claudia; Thorkelsson, Sigurdur R.; Fatalska, Agnieszka; Hodgson, George; Dalglish, Maximillian; Wang, Chao; Bertolotti, Anne
作者单位：MRC Laboratory Molecular Biology
摘要：Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by phosphorylation of eukaryotic translation initiation factor eIF2, which traps and inhibits rate-limiting translation factor eIF2B, thereby attenuating translation initiation. Termination of this pathway thus requires relieving eIF2B from P-eIF2 inhibition. Here, we found that eIF2 phosphatase subun...
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作者：Smith, Martin D.
作者单位：Duke University
