作者：Rubin, Adam J.; Dao, Tyler T.; Schueppert, Amelia V.; Choi, Saehyun; Groves, Jay T.; Regev, Aviv; Shalek, Alex K.
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Harvard Medical School; Ragon Institute; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); University of California System; University of California Berkeley; Massachusetts Institute of Technology (MIT)
摘要：The disordered adapter protein linker for activation of T cells (LAT) propagates T cell receptor signaling. To interrogate how LAT coordinates multiple downstream pathways, we developed a single-cell screening approach, identifying widespread functional segments including protein interaction motifs and blocks of negative charge. Regardless of their position in LAT, individual segments generally conferred defects across all downstream signaling pathways. To understand the underlying mechanism, ...
作者：De Strooper, Bart; Zetterberg, Henrik
作者单位：KU Leuven; Flanders Institute for Biotechnology (VIB); University of London; University College London; University of Gothenburg; University of Wisconsin System; University of Wisconsin Madison
作者：Gomez-Marin, Alex
作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Miguel Hernandez de Elche; CSIC-UMH - Instituto de Neurociencias de Alicante (IN)
作者：Sanfiorenzo, Charles; Wang, Kaihang
作者单位：California Institute of Technology
