6797期

最新文章

• How an HIV/AIDS tragedy spurred human evolution AI翻译
  作者：Cohen, Jon
• Contingent evolution of thick enamel by kangaroos to resist dietary abrasion AI翻译
  作者：Couzens, Aidan M. C.; King, Benedict; Prideaux, Gavin J.
  作者单位：Flinders University; Max Planck Society
  摘要：The late Cenozoic period saw widespread diversification of grazing hoofed mammals characterized by high-crowned molar teeth with low, thinly enameled crests. However, Australia's dominant grazing herbivores, the kangaroos, have much lower-crowned and higher-relief molars that are more akin to some archaic placental herbivores. Using x-ray microcomputed tomography scanning, we show that as kangaroos shifted to higher-abrasion grazing diets, their ancestrally vertical, interlocking mode of occlu...
• Trump fires entire body overseeing the National Science Foundation AI翻译
  作者：Mervis, Jeffrey
• From alchemy to precision skeletal editing AI翻译
  作者：Wu, Jimmy
  作者单位：Dartmouth College
• Success was never enough AI翻译
  作者：Glowacki, Tomasz
• AI can reason like a physician-what comes next? AI翻译
  作者：Hopkins, Ashley M.; Cornelisse, Erik
  作者单位：Flinders University
• Lymphoid tissue chemokines limit priming duration to preserve CD8+ T cell functionality AI翻译
  作者：Altenburger, Lukas M.; Carvoeiro, Daniela Claudino; Dehio, Philippe; Zhou, Jianwen; Laura, Chiara; Bofi I Cuadros, Alex; Katoch, Mitali; Kruger, Caroline; De Albuquerque, Juliana Barreto; Pfenninger, Petra; Magdaleno, Jose Martinez; Mehling, Matthias; Iannacone, Matteo; Gheinani, Ali Hashemi; Dengjel, Jorn; Abe, Jun; Stein, Jens V.
  作者单位：University of Fribourg; University of Basel; University of Fribourg; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; University of Erlangen Nuremberg; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; University of Bern; University of Bern; University Hospital of Bern; Harvard University; Harvard Medical School
  摘要：The generation of effector CD8+ T cells (TEFF) requires activation of na & iuml;ve CCR7+ T cells (TN) by dendritic cells (DCs) in lymphoid tissue. How TN-DC interaction duration and signal integration are controlled remains unclear. In this study, we show that lymphoid stroma-secreted CCR7 ligands limit interaction duration by progressively inducing CD8+ T cell release from DCs. At late interaction stages, CCR7 ligands relocalize the F-actin regulator DOCK2 away from the DC interface, permitti...
• Disneyland's factory-inspired future AI翻译
  作者：Blackburn, Renee
• Deeper detection limits in astronomical imaging using self-supervised spatiotemporal denoising AI翻译
  作者：Guo, Yuduo; Zhang, Hao; Li, Mingyu; Yu, Fujiang; Wu, Yunjing; Hao, Yuhan; Huang, Song; Liang, Yongming; Lin, Xiaojing; Li, Xinyang; Wu, Jiamin; Cai, Zheng; Dai, Qionghai
  作者单位：Tsinghua University; Tsinghua University; Tsinghua University; University of Tokyo; National Institutes of Natural Sciences (NINS) - Japan; National Astronomical Observatory of Japan (NAOJ); University of Tokyo; Tsinghua University; Qinghai University; Tsinghua University
  摘要：The detection limit of astronomical imaging observations is limited by several noise sources. Some of that noise is correlated between neighboring pixels and exposures, so in principle it could be learned and corrected. We present the Astronomical Self-supervised Transformer-based Denoising (ASTERIS) algorithm, which integrates spatiotemporal information across multiple exposures. Benchmarking on mock data indicated that ASTERIS improves detection limits by 1.0 magnitude at 90% completeness an...
• Gene syntax defines supercoiling-mediated transcriptional feedback AI翻译
  作者：Johnstone, Christopher P.; Love, Kasey S.; Kabaria, Sneha R.; Jones, Ross D.; Blanch-Asensio, Albert; Ploessl, Deon S.; Peterman, Emma L.; Lee, Rachel; Yun, Jiyoung; Oakes, Conrad G.; Mummery, Christine L.; Davis, Richard P.; DeKosky, Brandon J.; Zandstra, Peter W.; Galloway, Kate E.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of British Columbia; University of British Columbia; California Institute of Technology; Leiden University; Leiden University - Excl LUMC; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC)
  摘要：Gene syntax-the order and arrangement of genes and their regulatory elements-shapes the dynamic coordination of both natural and synthetic gene circuits. Transcription at one locus perturbs the transcription of adjacent genes, but the molecular basis of this effect remains poorly understood. In this work, we show that supercoiling-mediated feedback arises from transcription and regulates expression of adjacent genes in a syntax-specific manner. Using a suite of assays, we measured syntax- and ...