作者：Peng, Qi; Li, Jian; Jiang, Haihai; Cheng, Xinyu; Nag, Probal; Kleinau, Gunnar; Lamb, Trevor D.; Busche, Leon; Lu, Qiuyuan; Zhou, Sili; Liu, Yidi; Zhang, Yuting; Lv, Sijia; Wan, Shuangyan; Yang, Tingting; Chen, Yixiang; Zhang, Wei; Nan, Weiwei; Fu, Ying; Che, Tong; Li, Yanyan; Liao, Hongfei; Duan, Jingjing; Schapiro, Igor; Scheerer, Patrick; Zhang, Jin
作者单位：Nanchang University; Dortmund University of Technology; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Australian National University; John Curtin School of Medical Research; Southern University of Science & Technology; Southern University of Science & Technology; Nanchang University; Hebrew University of Jerusalem
摘要：Human trichromatic color vision relies on three cone opsins [long-, middle-, and short-wavelength-sensitive opsins (LWS-, MWS-, and SWS-opsins, respectively)], whereas scotopic rod vision is mediated by rhodopsin. Although the structure of rhodopsin was solved more than 20 years ago, cone opsin structures have been lacking. Here, we present cryo-electron microscopy structures of the three human cone opsins, each bound to a G protein and all-trans retinal in the presumed active state. All three...
作者：Ohashi, Sayaka; Katayama, Kota; Kojima, Asato; Yang, Xuchun; Fukuda, Masahiro; Sacchetta, Filippo; Suno, Ryoji; Sugita, Yukihiko; Nuemket, Nipawan; Kim, Suhyang; Kobayashi, Kazuhiro; Imai, Hiroo; Iwata, So; Nango, Eriko; Kobayashi, Takuya; Noda, Takeshi; Olivucci, Massimo; Kato, Hideaki E.; Kandori, Hideki
作者单位：Nagoya Institute of Technology; Japan Science & Technology Agency (JST); Japan Science & Technology Agency (JST); University of Tokyo; University of Siena; Japan Science & Technology Agency (JST); Kansai Medical University; Kyoto University; Japan Synchrotron Radiation Research Institute; RIKEN; Kyoto University; Kyoto University; Tohoku University; University System of Ohio; Bowling Green State University; University System of Ohio; Bowling Green State University
摘要：Color vision in catarrhine primates relies on red-, green-, and blue-sensitive cone pigments that share an 11-cis-retinal chromophore but differ in absorption maxima. Red and green pigments arose by recent gene duplication and differ at only a few residues. Here, we report cryo-electron microscopy structures of red and green cone pigments from the cynomolgus macaque (Macaca fascicularis) integrated with low-temperature vibrational spectroscopy and quantum mechanical and molecular mechanical mo...
