-
作者：Johnson, Tim E.; O'Neill, Craig; Turner, Simon; Kirkland, Christopher L.
作者单位：Curtin University; Queensland University of Technology (QUT); Macquarie University; Curtin University
摘要：The nature of Earth's crust during the Hadean eon [>= 4.03 billion years ago (Ga)] is uncertain. Numerical models of early Earth geodynamics emphasize the control of mantle temperature but generally consider only internally derived heat, despite empirical evidence for an intense Hadean impact flux. Using a stochastic model of that flux, we show that the time-integrated heat due to impacts would have dwarfed that produced internally throughout the Hadean. Earth's Hadean crust would have been ex...
-
作者：Kurmayer, Rainer
作者单位：University of Innsbruck
-
作者：Gibbons, Ann
-
作者：Mirzaei, Masoud; Shkarin, Alexey; Gurlek, Burak; Zirkelbach, Johannes; Shin, Ashley J.; Deperasinska, Irena; Kozankiewicz, Boleslaw; Utikal, Tobias; Gotzinger, Stephan; Sandoghdar, Vahid
作者单位：Max Planck Society; University of Erlangen Nuremberg; Max Planck Society; Polish Academy of Sciences; Institute of Physics - Polish Academy of Sciences; University of Erlangen Nuremberg
摘要：High-resolution spectroscopy allows the probing of weak interactions and subtle phenomena. Although such measurements are routinely performed in the gas phase and in crystalline materials, studies of adsorbed species on surfaces have previously fallen short of the ultimate spectral resolution, where dephasing is eliminated and the transition linewidth is determined by the excited-state lifetime. In this work, we devise an approach to surface preparation and deposition that provides access to F...
-
作者：Joelving, Frederik
-
作者：Wen, Alice X.; Bos, Julia; Panda, Debojyoti; Hagstrom, Katelin M.; Singh, Shubham; Mageswaran, Shrawan Kumar; Wang, Xiaoli; Hu, Bo; Welch, Kobie T.; Cooke, Matthew B.; Halliday, Jennifer A.; Ramirez, Laura Deus; Martinez, Antoinette E.; Chang, Yi-Wei; Weitz, David A.; Herman, Christophe
作者单位：Baylor College of Medicine; Baylor College of Medicine; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Pasteur Network; Institut Pasteur Paris; CNRS - National Institute for Biology (INSB); Harvard University; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; University of Pennsylvania; Pennsylvania Medicine; Baylor College of Medicine; University of Texas System; University of Texas Health Science Center Houston; University of Pennsylvania; Pennsylvania Medicine; Harvard University; Harvard University; Baylor College of Medicine; Baylor College of Medicine
摘要：The exchange of biological matter between bacterial cells drives adaptation and evolution. However, whether bacteria can exchange functional proteins remains unclear. In this work, we found that antibiotic treatment can induce vesicle-mediated horizontal protein transfer within and between bacterial species. We developed a genetic system in Escherichia coli to track transfer events and performed single-cell transcriptomic profiling on an isogenic population of bacteria. Antibiotics stimulated ...
-
作者：Tang, Qi; Ding, Chenxi; Zhang, Xiaotuo; Wang, Taiyun; Zhu, Mengjie; Cui, Ruixue; Yang, Wenya; Ma, Jinbiao; Ren, Guodong; Zhang, Xiaoming; Zheng, Binglian
作者单位：Fudan University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Zoology, CAS
摘要：Lariat RNAs are formed from introns during pre-messenger RNA splicing, after which they are degraded by the debranching enzyme DBR1. Impairment of DBR1 leads to developmental arrest, yet the mechanism remains unclear. In this study, we found that debranching of lariat RNA prevents production of 21- and 22-nucleotide lariat-derived small interfering RNAs (lasiRNAs), which causes a burst of exonic siRNAs, thereby safeguarding development and defense response. LasiRNA biogenesis relied on RNA-dep...
-
作者：Wintermantel, Dimitry; Kassie, Denicia; Hendricks-Franco, Lindsey; Knapp, Jessica; Jahnke, Annika; Breeze, Tom D.; Brown, Mark J. F.; Bruhl, Carsten A.; Dewaele, Justine; Fievet, Manon; Focks, Andreas; Gekiere, Antoine; Goulson, Dave; Hagedorn, Gregor; Huelsduenker, Timo; Ituarte-Lima, Claudia; Klein, Alexandra-Maria; Kling, Alicia; de Miranda, Joachim R.; Michez, Denis; Ozoh, Paul N.; Paxton, Robert J.; Pe'er, Guy; Potts, Simon G.; Riedel, Antonia; Rouillard, Josselin; Rundlof, Maj; Schafer, Ralf B.; Schaffer, Andreas; Sgolastra, Fabio; Slunge, Daniel; Topping, Christopher J.; Tosi, Simone; Vanbergen, Adam J.; Osterman, Julia
作者单位：University of Freiburg; Lund University; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); RWTH Aachen University; University of Reading; University of Cambridge; RPTU University Kaiserslautern; University of Mons; University Osnabruck; University of Sussex; Leibniz Institut fur Evolutions und Biodiversitatsforschung; University of Duisburg Essen; Lund University; Swedish University of Agricultural Sciences; University of Duisburg Essen; Martin Luther University Halle Wittenberg; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Lund University; Nanjing University; Chongqing University; University of Bologna; University of Gothenburg; Aarhus University; University of Turin; Universite Bourgogne Europe; INRAE; Institut Agro; Institut Agro Dijon; University of Gothenburg
-
作者：Zhao, Celina
-
作者：Liang, Lifan; Zhang, Siwei; Wang, Zicheng; Zhang, Hanwen; Li, Chuxuan; Thapa, Christina; Oh, Emily K.; Sirkin, David; Sun, Xiaotong; Barishman, Alexandra; McCarroll, Ada; Duhe, Alexandra C.; Qian, Sheng; Zhong, Xiaoyuan; Jamison, Brendan; Wood, Whitney; Kozlova, Alena; Pang, Zhiping P.; Sanders, Alan R.; He, Xin; Duan, Jubao
作者单位：University of Chicago; University of Pennsylvania; Pennsylvania Medicine; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; University of Chicago
摘要：Most causal variants for neuropsychiatric disorders (NPD) remain unknown. A major hurdle is that disease variants may act in specific contexts, such as during neuronal activation, which is difficult to study in vivo at the population level. We profiled single-nucleus neuron-activation multiomics in human induced pluripotent stem cell-derived neurons from 100 donors, revealing the NPD-relevant transcriptomic and epigenomic landscape of neuronal activation. We identified abundant genetic variant...
